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Gallstones in patients with inherited hemolytic diseases

The purpose is to provide an overview on the incidence of gallstone disease in patients with various types of inherited (chronic) hemolytic diseases at risk of cholelithiasis/choledocholithiasis with particular emphasis on its pathogenesis, genetic, risk factors and management. A detailed electronic...

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Main Authors: Uday Younis, Hussein, Naghem Farouk, Abed, Wisam Abdul Kadder, Yassin
Format: Article
Language:English
Published: 2015
Subjects:
R Medicine (General)
Online Access:http://eprints.unisza.edu.my/6502/1/FH02-FP-15-03538.jpg
http://eprints.unisza.edu.my/6502/
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spelling my-unisza-ir.65022022-09-13T04:55:03Z http://eprints.unisza.edu.my/6502/ Gallstones in patients with inherited hemolytic diseases Uday Younis, Hussein Naghem Farouk, Abed Wisam Abdul Kadder, Yassin R Medicine (General) The purpose is to provide an overview on the incidence of gallstone disease in patients with various types of inherited (chronic) hemolytic diseases at risk of cholelithiasis/choledocholithiasis with particular emphasis on its pathogenesis, genetic, risk factors and management. A detailed electronic literature search to determine the source of materials for this review article was done. The reported incidences of gallstones and choledocholithiasis vary according to the different types of inherited hemolytic diseases and the ethnicity of the studied populations. To date, no review article summarises the incidences of cholelithiasis in patients with various inherited haemolytic diseases was published. Regular ultrasound examination for the presence of gallstones recommended in patients with inherited haemolytic anaemias, particularly those with additional risk factors recommended. Further studies for evaluating the reasons for the higher incidence of cholelithiasis in thalassemia major and sickle cell anemia compared to hereditary spherocytosis; the effect of co inheritance of alpha thalassaemia on decreasing bilirubin level in patients with sickle cell disease and beta thalassaemia; the effect of the co inheritance of UGT1A1 and ABCG8 gene mutation on the incidence of gallstones in other blood diseases such as Hb-H disease, autoimmune haemolytic anaemias, congenital dyserythropoietic anaemia, hereditary elliptocytosis, Southeast Asian Ovalocytosis, glucose-6-phosphate and pyruvate kinase deficiency are recommended. Evaluation of the potential role of the solubility of the mutant proteins and haemoglobin subunit in the red blood cells as an additional mechanism for the development of gallstones in patients with inherited haemolytic anaemias recommended. 2015 Article PeerReviewed image en http://eprints.unisza.edu.my/6502/1/FH02-FP-15-03538.jpg Uday Younis, Hussein and Naghem Farouk, Abed and Wisam Abdul Kadder, Yassin (2015) Gallstones in patients with inherited hemolytic diseases. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (7). pp. 9-15. ISSN 09751491 [P]
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Uday Younis, Hussein
Naghem Farouk, Abed
Wisam Abdul Kadder, Yassin
Gallstones in patients with inherited hemolytic diseases
description The purpose is to provide an overview on the incidence of gallstone disease in patients with various types of inherited (chronic) hemolytic diseases at risk of cholelithiasis/choledocholithiasis with particular emphasis on its pathogenesis, genetic, risk factors and management. A detailed electronic literature search to determine the source of materials for this review article was done. The reported incidences of gallstones and choledocholithiasis vary according to the different types of inherited hemolytic diseases and the ethnicity of the studied populations. To date, no review article summarises the incidences of cholelithiasis in patients with various inherited haemolytic diseases was published. Regular ultrasound examination for the presence of gallstones recommended in patients with inherited haemolytic anaemias, particularly those with additional risk factors recommended. Further studies for evaluating the reasons for the higher incidence of cholelithiasis in thalassemia major and sickle cell anemia compared to hereditary spherocytosis; the effect of co inheritance of alpha thalassaemia on decreasing bilirubin level in patients with sickle cell disease and beta thalassaemia; the effect of the co inheritance of UGT1A1 and ABCG8 gene mutation on the incidence of gallstones in other blood diseases such as Hb-H disease, autoimmune haemolytic anaemias, congenital dyserythropoietic anaemia, hereditary elliptocytosis, Southeast Asian Ovalocytosis, glucose-6-phosphate and pyruvate kinase deficiency are recommended. Evaluation of the potential role of the solubility of the mutant proteins and haemoglobin subunit in the red blood cells as an additional mechanism for the development of gallstones in patients with inherited haemolytic anaemias recommended.
format Article
author Uday Younis, Hussein
Naghem Farouk, Abed
Wisam Abdul Kadder, Yassin
author_facet Uday Younis, Hussein
Naghem Farouk, Abed
Wisam Abdul Kadder, Yassin
author_sort Uday Younis, Hussein
title Gallstones in patients with inherited hemolytic diseases
title_short Gallstones in patients with inherited hemolytic diseases
title_full Gallstones in patients with inherited hemolytic diseases
title_fullStr Gallstones in patients with inherited hemolytic diseases
title_full_unstemmed Gallstones in patients with inherited hemolytic diseases
title_sort gallstones in patients with inherited hemolytic diseases
publishDate 2015
url http://eprints.unisza.edu.my/6502/1/FH02-FP-15-03538.jpg
http://eprints.unisza.edu.my/6502/
_version_ 1744358554376077312
score 13.211869

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