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The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats

Prescribed medications used to treat diabetes do not adequately inhibit the development of its associated complications, furthermore, they may cause different side effects. Hence, there is a demand for alternative therapies to manage diabetes and its associated complications. This study aimed to...

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Main Authors: Marwan Saad, Abdulrahman Azzubaidi, Basma Ezzat, Mustafa Al-Ahmad, Imad Matloub, Dally
Format: Article
Language:English
Published: 2019
Subjects:
R Medicine (General)
Online Access:http://eprints.unisza.edu.my/6283/1/FH02-FP-19-26715.pdf
http://eprints.unisza.edu.my/6283/
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spelling my-unisza-ir.62832022-03-16T03:39:47Z http://eprints.unisza.edu.my/6283/ The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats Marwan Saad, Abdulrahman Azzubaidi Basma Ezzat, Mustafa Al-Ahmad Imad Matloub, Dally R Medicine (General) Prescribed medications used to treat diabetes do not adequately inhibit the development of its associated complications, furthermore, they may cause different side effects. Hence, there is a demand for alternative therapies to manage diabetes and its associated complications. This study aimed to evaluate the hepatoprotective effects of flaxseed extract in streptozotocin(STZ)-induced diabetic rats. Diabetes mellitus was induced in Sprague-Dawley rats using a single injection of streptozotocin (60 mg/kg, intraperitoneally). The rats were divided into five groups of 8 animals each: Group NC, normal control rats; Group NF, normal rats treated with flaxseed extract (400 mg/kg); Group DC, diabetic control rats; Group DG, diabetic rats treated with glibenclamide (0.6 mg/kg); Group DF, diabetic rats treated with flaxseed extract (400 mg/kg); for 4 weeks. Body weight, liver relative weight, blood glucose level and liver enzymes were determined in all experimental rats. Results showed a significantly increased relative liver weight, blood glucose, AST, ALT, GGT, ALP, and LDH levels, and decreased body weight, total protein, albumin, and globulin levels in DC group comparing to NC group (p<0.05). The disturbance of these parameters was ameliorated in DF and DG groups, however, the ameliorative effect was significant in DG group only (p<0.05). These pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats. In conclusion, our data showed that flaxseed extract represents a potential alternative treatment to control diabetes mellitus and its related hepatopathy. 2019-08 Article PeerReviewed text en http://eprints.unisza.edu.my/6283/1/FH02-FP-19-26715.pdf Marwan Saad, Abdulrahman Azzubaidi and Basma Ezzat, Mustafa Al-Ahmad and Imad Matloub, Dally (2019) The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats. World Journal of Pharmacy and Pharmaceutical Sciences, 8 (8). pp. 780-798. ISSN 2278 – 4357
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Marwan Saad, Abdulrahman Azzubaidi
Basma Ezzat, Mustafa Al-Ahmad
Imad Matloub, Dally
The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats
description Prescribed medications used to treat diabetes do not adequately inhibit the development of its associated complications, furthermore, they may cause different side effects. Hence, there is a demand for alternative therapies to manage diabetes and its associated complications. This study aimed to evaluate the hepatoprotective effects of flaxseed extract in streptozotocin(STZ)-induced diabetic rats. Diabetes mellitus was induced in Sprague-Dawley rats using a single injection of streptozotocin (60 mg/kg, intraperitoneally). The rats were divided into five groups of 8 animals each: Group NC, normal control rats; Group NF, normal rats treated with flaxseed extract (400 mg/kg); Group DC, diabetic control rats; Group DG, diabetic rats treated with glibenclamide (0.6 mg/kg); Group DF, diabetic rats treated with flaxseed extract (400 mg/kg); for 4 weeks. Body weight, liver relative weight, blood glucose level and liver enzymes were determined in all experimental rats. Results showed a significantly increased relative liver weight, blood glucose, AST, ALT, GGT, ALP, and LDH levels, and decreased body weight, total protein, albumin, and globulin levels in DC group comparing to NC group (p<0.05). The disturbance of these parameters was ameliorated in DF and DG groups, however, the ameliorative effect was significant in DG group only (p<0.05). These pathological changes were ameliorated in the flaxseed extract and glibenclamide treated rats. In conclusion, our data showed that flaxseed extract represents a potential alternative treatment to control diabetes mellitus and its related hepatopathy.
format Article
author Marwan Saad, Abdulrahman Azzubaidi
Basma Ezzat, Mustafa Al-Ahmad
Imad Matloub, Dally
author_facet Marwan Saad, Abdulrahman Azzubaidi
Basma Ezzat, Mustafa Al-Ahmad
Imad Matloub, Dally
author_sort Marwan Saad, Abdulrahman Azzubaidi
title The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats
title_short The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats
title_full The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats
title_fullStr The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats
title_full_unstemmed The effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats
title_sort effect of flax seed extract on the blood glucose level and liver bio markers in diabetic rats
publishDate 2019
url http://eprints.unisza.edu.my/6283/1/FH02-FP-19-26715.pdf
http://eprints.unisza.edu.my/6283/
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score 13.211869

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