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Evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of aeglemarmelos attributes towards ductal carcinoma studied in MCF7 cells

Objective: The objective of the present research work had been made to evaluate the antioxidant potential along with anti-cancer activity of methanolic extracts from the leaf of A. marmelos. Methods: Standard methods for antioxidant potential in terms of DPPH and nitric oxide scavenging assay, and a...

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Main Authors: U.S. Mahadeva, Rao, B., Arirudran, B., Janani
Format: Article
Language:English
Published: Innovare Academic Sciences Pvt Ltd 2019
Subjects:
QD Chemistry
Online Access:http://eprints.unisza.edu.my/6176/1/FH02-FP-19-25908.pdf
http://eprints.unisza.edu.my/6176/
http://dx.doi.org/10.22159/ijpps.2019v11i2.28940
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spelling my-unisza-ir.61762022-03-14T03:38:39Z http://eprints.unisza.edu.my/6176/ Evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of aeglemarmelos attributes towards ductal carcinoma studied in MCF7 cells U.S. Mahadeva, Rao B., Arirudran B., Janani QD Chemistry Objective: The objective of the present research work had been made to evaluate the antioxidant potential along with anti-cancer activity of methanolic extracts from the leaf of A. marmelos. Methods: Standard methods for antioxidant potential in terms of DPPH and nitric oxide scavenging assay, and anticancer activity in vitro method (Cytotoxicity/MTT assay and % of cell viability) by using MCF7 cell line. Results: Results of antioxidant efficacy revealed that the IC50 value for DPPH and nitric oxide scavenging assay was considered to be 62.032%, and 20.69% respectively. The methanolic extract of A. marmelos was found to possess enhanced anticancer potential against MCF7 cells. Cytotoxicity activity of MCF7 cells, when treated with methanolic extract of A. marmelos, was found to be 43.42% at 25µg, 52.31% at 50µg, 56.31% at 75µg, 58.38% at 100µg, 62.25% at 125µg. The IC50 value was found as 49.36µg. Toxicity was significantly increased with increased concentration and viability significantly decreased with the increased concentration of methanolic extract of leaf from A. marmelos for MCF7 cell when compared to cyclophosphamide. Conclusion: From the studies, it was postulated that methanolic extract of leaf from A. marmeloshas significant chemopreventive activity. These specific identities will be useful for the identification and authentication of raw drug. Innovare Academic Sciences Pvt Ltd 2019-07 Article PeerReviewed text en http://eprints.unisza.edu.my/6176/1/FH02-FP-19-25908.pdf U.S. Mahadeva, Rao and B., Arirudran and B., Janani (2019) Evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of aeglemarmelos attributes towards ductal carcinoma studied in MCF7 cells. International Journal of Pharmacy and Pharmaceutical Sciences, 11 (2). pp. 21-25. ISSN 0975-1491 http://dx.doi.org/10.22159/ijpps.2019v11i2.28940
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
U.S. Mahadeva, Rao
B., Arirudran
B., Janani
Evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of aeglemarmelos attributes towards ductal carcinoma studied in MCF7 cells
description Objective: The objective of the present research work had been made to evaluate the antioxidant potential along with anti-cancer activity of methanolic extracts from the leaf of A. marmelos. Methods: Standard methods for antioxidant potential in terms of DPPH and nitric oxide scavenging assay, and anticancer activity in vitro method (Cytotoxicity/MTT assay and % of cell viability) by using MCF7 cell line. Results: Results of antioxidant efficacy revealed that the IC50 value for DPPH and nitric oxide scavenging assay was considered to be 62.032%, and 20.69% respectively. The methanolic extract of A. marmelos was found to possess enhanced anticancer potential against MCF7 cells. Cytotoxicity activity of MCF7 cells, when treated with methanolic extract of A. marmelos, was found to be 43.42% at 25µg, 52.31% at 50µg, 56.31% at 75µg, 58.38% at 100µg, 62.25% at 125µg. The IC50 value was found as 49.36µg. Toxicity was significantly increased with increased concentration and viability significantly decreased with the increased concentration of methanolic extract of leaf from A. marmelos for MCF7 cell when compared to cyclophosphamide. Conclusion: From the studies, it was postulated that methanolic extract of leaf from A. marmeloshas significant chemopreventive activity. These specific identities will be useful for the identification and authentication of raw drug.
format Article
author U.S. Mahadeva, Rao
B., Arirudran
B., Janani
author_facet U.S. Mahadeva, Rao
B., Arirudran
B., Janani
author_sort U.S. Mahadeva, Rao
title Evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of aeglemarmelos attributes towards ductal carcinoma studied in MCF7 cells
title_short Evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of aeglemarmelos attributes towards ductal carcinoma studied in MCF7 cells
title_full Evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of aeglemarmelos attributes towards ductal carcinoma studied in MCF7 cells
title_fullStr Evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of aeglemarmelos attributes towards ductal carcinoma studied in MCF7 cells
title_full_unstemmed Evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of aeglemarmelos attributes towards ductal carcinoma studied in MCF7 cells
title_sort evaluation of antioxidant and chemopreventive potential of methanolic extracts of leaf of aeglemarmelos attributes towards ductal carcinoma studied in mcf7 cells
publisher Innovare Academic Sciences Pvt Ltd
publishDate 2019
url http://eprints.unisza.edu.my/6176/1/FH02-FP-19-25908.pdf
http://eprints.unisza.edu.my/6176/
http://dx.doi.org/10.22159/ijpps.2019v11i2.28940
_version_ 1728056331302076416
score 13.211869

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