Malaysian obesity DNA bank; Towards developing anti obese nation wide strategy
The pathophysiology of obesity being multifaceted disorder involves intricate choreography of environmental, behavioural and genetic factors. The genetics factors may influence metabolism or diet intake thus leading to increased adiposity. In order to understand the interaction and role of differe...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/5859/1/FH02-FP-18-13166.pdf http://eprints.unisza.edu.my/5859/ |
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| Summary: | The pathophysiology of obesity being multifaceted disorder involves intricate choreography of environmental,
behavioural and genetic factors. The genetics factors may influence metabolism or diet intake thus leading to
increased adiposity. In order to understand the interaction and role of different candidate genes reported to be
involved in obesity, there is a need to get the complete pattern for a better understanding of the genetics factors
associated with obesity. To develop the Malaysian obesity DNA bank for future studies on obesity towards
developing anti-obesity nation-wide strategy. Malay subjects have been recruited from Terengganu after the
approval of ethical approvals from respective agencies and departments. The samples have been recruited in
three stages; pre-screening via official letters and phone connections on the basis of promotion of health
knowledge. It has been followed by screening phase via BMI calculations as per WHO criterion. The Last phase
has been enrolment of subjects to be involved in obesity research. Till date we have recruited a total of 450
samples as per inclusion and exclusion criterion beside, the control samples from normal healthy individuals
who are not tested for genotypically normality but are phenotypically normal. The data is well curated and
recorded with the index number of sample and subject indexing to access samples, when required. Samples are
stored well as per regulation of DNA storage. We have developed successfully the first Malaysian obesity DNA
bank at faculty of medicine, Universiti Sultan Zainal Abidin for obesity related. The future undertakings will be
focusing to provide a free service for the genetic pattern of their obesity status. |
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