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Quantification of Antinuclear Antibodies (IgG) Existence in General Population of Pakistan

The autoimmune disorders and auto antibodies are rapidly becoming a major cause of concern in the medical field. Antinuclear antibody plays a significant role in autoimmunity and it is targeted against different nuclear antigens. Although its elevated levels are found in autoimmune disorders but it...

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Main Authors: Atif Amin, Baig, Salman, Amiruddin, Ahmad Zubaidi, A.latif, Nordin, Simbak
Format: Article
Language:English
Published: 2018
Subjects:
R Medicine (General)
Online Access:http://eprints.unisza.edu.my/5699/1/FH02-FP-19-24395.pdf
http://eprints.unisza.edu.my/5699/
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spelling my-unisza-ir.56992022-02-23T03:08:25Z http://eprints.unisza.edu.my/5699/ Quantification of Antinuclear Antibodies (IgG) Existence in General Population of Pakistan Atif Amin, Baig Salman, Amiruddin Ahmad Zubaidi, A.latif Nordin, Simbak R Medicine (General) The autoimmune disorders and auto antibodies are rapidly becoming a major cause of concern in the medical field. Antinuclear antibody plays a significant role in autoimmunity and it is targeted against different nuclear antigens. Although its elevated levels are found in autoimmune disorders but it is also synthesizedin healthy individuals. To find out its incidence a number of studies have been conducted on healthy individuals of various populations but limited data is available about the frequency of auto antibodiesin Pakistan. Blood samples of 587 (503 females and 84 males) individuals were taken through convenience sampling technique. Serum was separated by centrifugation and then ANA titer was determined by Enzyme Linked Immunosorbent Assay (ELISA). SPSS version 20.0 (IBM-SPSS, Inc, Armonk, New York) was used for statistical calculations.ANA autoantibodies were found only in 6 individuals,out of which 5 were females and 1 was male. No significant association of antinuclear antibodies was observed between males and females. Evaluation of the incidence of ANA in general population is important to ensure its reliability as a biomarker of disease. Current study found very low occurrence of ANA in general population, which indicates its exclusive association with the diseases especiallyautoimmune diseases. The one percent positive cases can be further followed up for being at risk of developing disease. 2018-12 Article PeerReviewed text en http://eprints.unisza.edu.my/5699/1/FH02-FP-19-24395.pdf Atif Amin, Baig and Salman, Amiruddin and Ahmad Zubaidi, A.latif and Nordin, Simbak (2018) Quantification of Antinuclear Antibodies (IgG) Existence in General Population of Pakistan. Research Journal of Pharmacy and Technology, 11 (10). pp. 4339-4342. ISSN 0974-3618
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Atif Amin, Baig
Salman, Amiruddin
Ahmad Zubaidi, A.latif
Nordin, Simbak
Quantification of Antinuclear Antibodies (IgG) Existence in General Population of Pakistan
description The autoimmune disorders and auto antibodies are rapidly becoming a major cause of concern in the medical field. Antinuclear antibody plays a significant role in autoimmunity and it is targeted against different nuclear antigens. Although its elevated levels are found in autoimmune disorders but it is also synthesizedin healthy individuals. To find out its incidence a number of studies have been conducted on healthy individuals of various populations but limited data is available about the frequency of auto antibodiesin Pakistan. Blood samples of 587 (503 females and 84 males) individuals were taken through convenience sampling technique. Serum was separated by centrifugation and then ANA titer was determined by Enzyme Linked Immunosorbent Assay (ELISA). SPSS version 20.0 (IBM-SPSS, Inc, Armonk, New York) was used for statistical calculations.ANA autoantibodies were found only in 6 individuals,out of which 5 were females and 1 was male. No significant association of antinuclear antibodies was observed between males and females. Evaluation of the incidence of ANA in general population is important to ensure its reliability as a biomarker of disease. Current study found very low occurrence of ANA in general population, which indicates its exclusive association with the diseases especiallyautoimmune diseases. The one percent positive cases can be further followed up for being at risk of developing disease.
format Article
author Atif Amin, Baig
Salman, Amiruddin
Ahmad Zubaidi, A.latif
Nordin, Simbak
author_facet Atif Amin, Baig
Salman, Amiruddin
Ahmad Zubaidi, A.latif
Nordin, Simbak
author_sort Atif Amin, Baig
title Quantification of Antinuclear Antibodies (IgG) Existence in General Population of Pakistan
title_short Quantification of Antinuclear Antibodies (IgG) Existence in General Population of Pakistan
title_full Quantification of Antinuclear Antibodies (IgG) Existence in General Population of Pakistan
title_fullStr Quantification of Antinuclear Antibodies (IgG) Existence in General Population of Pakistan
title_full_unstemmed Quantification of Antinuclear Antibodies (IgG) Existence in General Population of Pakistan
title_sort quantification of antinuclear antibodies (igg) existence in general population of pakistan
publishDate 2018
url http://eprints.unisza.edu.my/5699/1/FH02-FP-19-24395.pdf
http://eprints.unisza.edu.my/5699/
_version_ 1725976983966318592
score 13.211869

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