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Pharmacogenovigilance: A Potential Tool in Pharmacovigilance

Pharmacogenovigilance is a program which can be developed by integrating pharmacogenomics into a pharmacovigilance studies. The fact that genes play a vital role in variability in response to medicines makes pharmacogenomic of adverse drug reactions (ADRs) very essential program. Genetic variation...

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Main Authors: Mainul, Haque, Nordin, Simbak, Adamu, Yau
Format: Article
Language:English
English
Published: 2014
Subjects:
QH301 Biology
R Medicine (General)
Online Access:http://eprints.unisza.edu.my/5664/1/FH02-FP-15-03090.pdf
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spelling my-unisza-ir.56642022-09-13T05:25:04Z http://eprints.unisza.edu.my/5664/ Pharmacogenovigilance: A Potential Tool in Pharmacovigilance Mainul, Haque Nordin, Simbak Adamu, Yau QH301 Biology R Medicine (General) Pharmacogenovigilance is a program which can be developed by integrating pharmacogenomics into a pharmacovigilance studies. The fact that genes play a vital role in variability in response to medicines makes pharmacogenomic of adverse drug reactions (ADRs) very essential program. Genetic variations have significantly affected the drug action in many patients, and a time predisposes patient to uncommon ADRs that are not seen in other patients. Pharmacogenetics provides greener path to individualized use of medicines, drug safety and efficacy studies due to genetic polymorphism. In order to explore these potential benefits, integration of pharmacogenovigilance in to clinical practice and public health system has become necessary. It is imperative for every medical practitioner to consider genetic factors in order to prescribe the best medication to his patients. Literature search using terms genetic biomarkers, application of pharmacogenetics and pharmacogenomics, and influence of pharmacogenetics on pharmacovigilance was done using PubMed, PhamaKG, US FDA and WHO websites. Several challenges facing drug safety and pharmacovigilance were highlighted and proposed pharmacogenomics approaches in solving them. The purpose of this article is to justify pharmacogenovigilance as an essential tool for drug safety and efficacy while providing the most feasible way for its successful integration in to the cycle of patients care. In conclusion, considerable progresses have been recorded on the potentials of pharmacogenovigilance in drug safety and efficacy study during post-marketing surveillance, and based on the provided evidences, the right time for pharmacogenovigilance is now. 2014-12 Article PeerReviewed text en http://eprints.unisza.edu.my/5664/1/FH02-FP-15-03090.pdf image en http://eprints.unisza.edu.my/5664/2/FH02-FP-16-05369.jpg Mainul, Haque and Nordin, Simbak and Adamu, Yau (2014) Pharmacogenovigilance: A Potential Tool in Pharmacovigilance. Research Journal of Pharmacy and Technology, 7 (12). pp. 1476-1482. ISSN 0974-3618
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
English
topic QH301 Biology
R Medicine (General)
spellingShingle QH301 Biology
R Medicine (General)
Mainul, Haque
Nordin, Simbak
Adamu, Yau
Pharmacogenovigilance: A Potential Tool in Pharmacovigilance
description Pharmacogenovigilance is a program which can be developed by integrating pharmacogenomics into a pharmacovigilance studies. The fact that genes play a vital role in variability in response to medicines makes pharmacogenomic of adverse drug reactions (ADRs) very essential program. Genetic variations have significantly affected the drug action in many patients, and a time predisposes patient to uncommon ADRs that are not seen in other patients. Pharmacogenetics provides greener path to individualized use of medicines, drug safety and efficacy studies due to genetic polymorphism. In order to explore these potential benefits, integration of pharmacogenovigilance in to clinical practice and public health system has become necessary. It is imperative for every medical practitioner to consider genetic factors in order to prescribe the best medication to his patients. Literature search using terms genetic biomarkers, application of pharmacogenetics and pharmacogenomics, and influence of pharmacogenetics on pharmacovigilance was done using PubMed, PhamaKG, US FDA and WHO websites. Several challenges facing drug safety and pharmacovigilance were highlighted and proposed pharmacogenomics approaches in solving them. The purpose of this article is to justify pharmacogenovigilance as an essential tool for drug safety and efficacy while providing the most feasible way for its successful integration in to the cycle of patients care. In conclusion, considerable progresses have been recorded on the potentials of pharmacogenovigilance in drug safety and efficacy study during post-marketing surveillance, and based on the provided evidences, the right time for pharmacogenovigilance is now.
format Article
author Mainul, Haque
Nordin, Simbak
Adamu, Yau
author_facet Mainul, Haque
Nordin, Simbak
Adamu, Yau
author_sort Mainul, Haque
title Pharmacogenovigilance: A Potential Tool in Pharmacovigilance
title_short Pharmacogenovigilance: A Potential Tool in Pharmacovigilance
title_full Pharmacogenovigilance: A Potential Tool in Pharmacovigilance
title_fullStr Pharmacogenovigilance: A Potential Tool in Pharmacovigilance
title_full_unstemmed Pharmacogenovigilance: A Potential Tool in Pharmacovigilance
title_sort pharmacogenovigilance: a potential tool in pharmacovigilance
publishDate 2014
url http://eprints.unisza.edu.my/5664/1/FH02-FP-15-03090.pdf
http://eprints.unisza.edu.my/5664/2/FH02-FP-16-05369.jpg
http://eprints.unisza.edu.my/5664/
_version_ 1744358534658654208
score 13.211869

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