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Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer

Peptic ulcer is a disease of the Gastro-intestinal tract (GIT), which includes both gastric and duodenal ulcers. The occurrence of peptic ulcer disease has been attributed to the imbalance between aggressive factors like acid, pepsin, and Helicobacter infection on one hand and the...

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Main Authors:	Khamsah Suryati, Mohd, Thant, Zin, U.S. Mahadeva, Rao
Format:	Article
Language:	English
Published:	2014
Subjects:	R Medicine (General)
Online Access:	http://eprints.unisza.edu.my/5507/1/FH02-FPSK-06-01522.jpg http://eprints.unisza.edu.my/5507/
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spelling	my-unisza-ir.55072022-09-13T05:31:00Z http://eprints.unisza.edu.my/5507/ Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer Khamsah Suryati, Mohd Thant, Zin U.S. Mahadeva, Rao R Medicine (General) Peptic ulcer is a disease of the Gastro-intestinal tract (GIT), which includes both gastric and duodenal ulcers. The occurrence of peptic ulcer disease has been attributed to the imbalance between aggressive factors like acid, pepsin, and Helicobacter infection on one hand and the local mucosa defenses like bicarbonate and mucus secretion and prostaglandins synthesis on the other hand. The most serious complications of peptic ulcer disease include hemorrhage, perforation, penetration, and gastric outlet obstruction. Ulcerative colitis is a form of inflammatory bowel disease (IBD). It is a form of colitis, a disease of the colon that includes characteristic ulcers, or open sores. IBD is often confused with irritable bowel syndrome. Ulcerative colitis is associated with a general inflammatory process that affects many parts of the body. Sometimes these associated extra-intestinal symptoms are the initial signs of the disease, such as painful arthritic knees in a teenager and may be seen in adults also. Several classes of pharmacological agents have proved to be effective in the management of the acid peptic disorders viz., antacids, acid suppressive agents, anticholinergic, cytoprotective agents, etc. A widespread search has been launched to identify new anti-ulcer therapies from natural sources to replace currently used drugs of doubtful efficacy and safety. Herbs, medicinal plants, spices, vegetables and crude drug substances are considered to be a potential source to control various diseases including gastric ulcer and ulcerative colitis. In the scientific literature, a large number of medicinal plants and their secondary metabolites with anti-ulcer potential have been reported. As the gastro protective effect can be linked to different mechanisms, once demonstrated the activity, the extracts and more appropriately the active compounds should be assessed for action mechanisms to elucidate their mode of action. Besides, new action mechanisms may be discovered. 2014-01 Article PeerReviewed image en http://eprints.unisza.edu.my/5507/1/FH02-FPSK-06-01522.jpg Khamsah Suryati, Mohd and Thant, Zin and U.S. Mahadeva, Rao (2014) Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer. Journal of Applied Pharmaceutical Science, 4 (8). pp. 80-90. ISSN 22313354 [P]
institution	Universiti Sultan Zainal Abidin
building	UNISZA Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Sultan Zainal Abidin
content_source	UNISZA Institutional Repository
url_provider	https://eprints.unisza.edu.my/
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Khamsah Suryati, Mohd Thant, Zin U.S. Mahadeva, Rao Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer
description	Peptic ulcer is a disease of the Gastro-intestinal tract (GIT), which includes both gastric and duodenal ulcers. The occurrence of peptic ulcer disease has been attributed to the imbalance between aggressive factors like acid, pepsin, and Helicobacter infection on one hand and the local mucosa defenses like bicarbonate and mucus secretion and prostaglandins synthesis on the other hand. The most serious complications of peptic ulcer disease include hemorrhage, perforation, penetration, and gastric outlet obstruction. Ulcerative colitis is a form of inflammatory bowel disease (IBD). It is a form of colitis, a disease of the colon that includes characteristic ulcers, or open sores. IBD is often confused with irritable bowel syndrome. Ulcerative colitis is associated with a general inflammatory process that affects many parts of the body. Sometimes these associated extra-intestinal symptoms are the initial signs of the disease, such as painful arthritic knees in a teenager and may be seen in adults also. Several classes of pharmacological agents have proved to be effective in the management of the acid peptic disorders viz., antacids, acid suppressive agents, anticholinergic, cytoprotective agents, etc. A widespread search has been launched to identify new anti-ulcer therapies from natural sources to replace currently used drugs of doubtful efficacy and safety. Herbs, medicinal plants, spices, vegetables and crude drug substances are considered to be a potential source to control various diseases including gastric ulcer and ulcerative colitis. In the scientific literature, a large number of medicinal plants and their secondary metabolites with anti-ulcer potential have been reported. As the gastro protective effect can be linked to different mechanisms, once demonstrated the activity, the extracts and more appropriately the active compounds should be assessed for action mechanisms to elucidate their mode of action. Besides, new action mechanisms may be discovered.
format	Article
author	Khamsah Suryati, Mohd Thant, Zin U.S. Mahadeva, Rao
author_facet	Khamsah Suryati, Mohd Thant, Zin U.S. Mahadeva, Rao
author_sort	Khamsah Suryati, Mohd
title	Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer
title_short	Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer
title_full	Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer
title_fullStr	Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer
title_full_unstemmed	Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer
title_sort	reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer
publishDate	2014
url	http://eprints.unisza.edu.my/5507/1/FH02-FPSK-06-01522.jpg http://eprints.unisza.edu.my/5507/
_version_	1744358527227396096
score	13.211869

Reviews of herbal and their secondary metabolites in the treatment of ulcerative colitis and peptic ulcer

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