Modulatory Effect of Mengkudu Fruit on the Activities of Key Enzymes of Glucose Synthesis and Utilization Pathways of Diabetic Induced Rats
Objective: The present study was aimed to screen the secondary metabolites and evaluate the ameliorative potential of ethanolic extract of Morinda citrifolia (Mengkudu) Fruit Extract (MFE) on the glucose synthesis and utilization reactions. Methods: The phytochemicals present in the Mengkudu frui...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/4389/3/FH02-FPSK-14-00595.pdf http://eprints.unisza.edu.my/4389/ |
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| Summary: | Objective: The present study was aimed to screen the secondary metabolites and evaluate
the ameliorative potential of ethanolic extract of Morinda citrifolia (Mengkudu) Fruit Extract
(MFE) on the glucose synthesis and utilization reactions.
Methods: The phytochemicals present in the Mengkudu fruit extract were qualitatively
investigated. The blood glucose, glycogen content, and plasma insulin profiles and the activities of the key enzymes of glucose oxidation, and gluconeogenic pathways and glycogen
metabolism in liver and kidney tissues in streptozotocin (STZ) induced experimental diabetic
albino rats were assessed.
Results: The diabetic rats orally treated with MFE (300 mg/kg b.w./day) for 30 days resulted
in significant plunge in blood glucose, glycosylated hemoglobin levels and upswing in
glycogen content and a significant progress in plasma insulin and C-peptide level. The
distorted activities of key enzymes of glycolysis, TCA cycle, HMP shunt, gluconeogenesis,
and glycogen metabolism such as glycogenesis and glycogenolysis pathways observed in
liver and kidney tissues of diabetic rats were significantly reverted to near normalcy by the
oral administration of MFE. Further, the results were compared with gliclazide, an oral
standard drug.
Conclusion: The results of the current study indicate that this fruit plays an indispensable
character in regulating key enzymes of glucose synthesis and utilization reactions to
sustain normoglycemia. Moreover consumption of Mengkudu fruit is nontoxic to the
system and is hepatoprotective. Presence of biologically active ingredients such as alkaloids, flavonoids, triterpenoids, minerals, and vitamins presumed to account for the anti-hyperglycemic properties of M. citrifolia fruits. |
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