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Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats

This study was carried out to evaluate the total phenolic content and anti-oxidant activity of methanolic extract of red pitaya, and hypocholesterolemic effect of red pitaya (Hylocereus sp.) on lipid profiles status on hypercholesterolemia induced rats. From the analysis, total phenolic conten...

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Main Authors: Rohin, Mohd Adzim Khalili, Ali, Abd Manaf, Abd. Hadi, Norhayati, Mat Hasan, Siti Asmah
Format: Article
Language:English
Published: 2009
Subjects:
QD Chemistry
Online Access:http://eprints.unisza.edu.my/2744/1/FH02-FPBSM-14-00407.pdf
http://eprints.unisza.edu.my/2744/
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spelling my-unisza-ir.27442022-09-13T05:06:27Z http://eprints.unisza.edu.my/2744/ Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats Rohin, Mohd Adzim Khalili Ali, Abd Manaf Abd. Hadi, Norhayati Mat Hasan, Siti Asmah QD Chemistry This study was carried out to evaluate the total phenolic content and anti-oxidant activity of methanolic extract of red pitaya, and hypocholesterolemic effect of red pitaya (Hylocereus sp.) on lipid profiles status on hypercholesterolemia induced rats. From the analysis, total phenolic content in red pitaya is 46.06 ± 1.77 mg GAE/100 g fresh weight and antioxidant activity is 76.10% using FTC method. TBA analysis also showed red pitaya extract had high antioxidant effect (72.90%). An in-vivo study also showed red pitaya has hypocholesterolemic effect on induced hypercholesterolemia rats. After 11 weeks of study, total blood cholesterol significant decrease (p<0.05) in the groups supplement with red pitaya. The total cholesterol (TC) level for group PF1 were reduced from 3.356 mmol/L to 1.707 mmol/L (49.14%), group PF2 reduced from 3.435 mmol/L to 1.487 mmol/L (56.72%) and group PF3 reduced from 3.448 mmol/L to 1.412 mmol/L (59.06%) as compare to baseline respectively. The mean total cholesterol level in both negative (N – 5.12%) and positive controls (group HC – 13.79%) were not significantly different (p<0.05). The mean triglycerides (TG) level for all groups had shown a reduction (p<0.05) with value of 23.87% (group N), 22.674% (group HC), 42.81% (group PF1), 52.82% (group PF2) and 59.52% (group PF3) as compare to baseline levels. The mean HDL level increased by about 2.12% (group N), 19.31% (group PF1), 21.93% (group PF2) and much higher increase in group PF3 (34.42%). The mean LDL decreased by about 39.06% (PF3), 15.10% (PF2), 1.50% (PF1) and 4.33% (group N). The positive control has showed significantly increase with the mean value for 25.68%. In conclusion, all groups that received red pitaya supplementation has high antioxidant properties and showed a good results in managing of lipid profile. It was suggested that the consumption of red pitaya demonstrated the potential to reduce dyslipidemia and play a role in the prevention of cardiovascular disease. 2009 Article PeerReviewed text en http://eprints.unisza.edu.my/2744/1/FH02-FPBSM-14-00407.pdf Rohin, Mohd Adzim Khalili and Ali, Abd Manaf and Abd. Hadi, Norhayati and Mat Hasan, Siti Asmah (2009) Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats. International Food Research Journal. pp. 431-440. ISSN 19854668
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Rohin, Mohd Adzim Khalili
Ali, Abd Manaf
Abd. Hadi, Norhayati
Mat Hasan, Siti Asmah
Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats
description This study was carried out to evaluate the total phenolic content and anti-oxidant activity of methanolic extract of red pitaya, and hypocholesterolemic effect of red pitaya (Hylocereus sp.) on lipid profiles status on hypercholesterolemia induced rats. From the analysis, total phenolic content in red pitaya is 46.06 ± 1.77 mg GAE/100 g fresh weight and antioxidant activity is 76.10% using FTC method. TBA analysis also showed red pitaya extract had high antioxidant effect (72.90%). An in-vivo study also showed red pitaya has hypocholesterolemic effect on induced hypercholesterolemia rats. After 11 weeks of study, total blood cholesterol significant decrease (p<0.05) in the groups supplement with red pitaya. The total cholesterol (TC) level for group PF1 were reduced from 3.356 mmol/L to 1.707 mmol/L (49.14%), group PF2 reduced from 3.435 mmol/L to 1.487 mmol/L (56.72%) and group PF3 reduced from 3.448 mmol/L to 1.412 mmol/L (59.06%) as compare to baseline respectively. The mean total cholesterol level in both negative (N – 5.12%) and positive controls (group HC – 13.79%) were not significantly different (p<0.05). The mean triglycerides (TG) level for all groups had shown a reduction (p<0.05) with value of 23.87% (group N), 22.674% (group HC), 42.81% (group PF1), 52.82% (group PF2) and 59.52% (group PF3) as compare to baseline levels. The mean HDL level increased by about 2.12% (group N), 19.31% (group PF1), 21.93% (group PF2) and much higher increase in group PF3 (34.42%). The mean LDL decreased by about 39.06% (PF3), 15.10% (PF2), 1.50% (PF1) and 4.33% (group N). The positive control has showed significantly increase with the mean value for 25.68%. In conclusion, all groups that received red pitaya supplementation has high antioxidant properties and showed a good results in managing of lipid profile. It was suggested that the consumption of red pitaya demonstrated the potential to reduce dyslipidemia and play a role in the prevention of cardiovascular disease.
format Article
author Rohin, Mohd Adzim Khalili
Ali, Abd Manaf
Abd. Hadi, Norhayati
Mat Hasan, Siti Asmah
author_facet Rohin, Mohd Adzim Khalili
Ali, Abd Manaf
Abd. Hadi, Norhayati
Mat Hasan, Siti Asmah
author_sort Rohin, Mohd Adzim Khalili
title Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats
title_short Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats
title_full Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats
title_fullStr Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats
title_full_unstemmed Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats
title_sort hypocholesterolemic effect of red pitaya (hylocereus sp.) on hypercholesterolemia induced rats
publishDate 2009
url http://eprints.unisza.edu.my/2744/1/FH02-FPBSM-14-00407.pdf
http://eprints.unisza.edu.my/2744/
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score 13.211869

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