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Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result

The default mode network (DMN) is thought to be impaired in epileptic patients, where the functional integrity of its core regions compromised. Fourteen healthy participants and fourteen aged and gender-matched patients with temporal lobe epilepsy (TLE) took part in this study. The resting-state...

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Main Authors:	Shuhada, J.M., Husbani, M.A.R., A I A, Hamid, Muhammad, A.R.
Format:	Conference or Workshop Item
Language:	English
Published:	2020
Subjects:	R Medicine (General) RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:	http://eprints.unisza.edu.my/1930/1/FH03-FP-20-39282.pdf http://eprints.unisza.edu.my/1930/
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spelling	my-unisza-ir.19302020-11-25T01:36:14Z http://eprints.unisza.edu.my/1930/ Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result Shuhada, J.M. Husbani, M.A.R. A I A, Hamid Muhammad, A.R. R Medicine (General) RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry The default mode network (DMN) is thought to be impaired in epileptic patients, where the functional integrity of its core regions compromised. Fourteen healthy participants and fourteen aged and gender-matched patients with temporal lobe epilepsy (TLE) took part in this study. The resting-state fMRI (rsfMRI) imaging protocol was executed using a 3-T Phillips Achieva MRI scanner at the Department of Radiology, HUSM. The TLE patient displays decreased activation clusters in precuneus and supramarginal gyrus compared to the healthy group. However increased activation clusters were found on middle frontal gyrus, superior temporal gyrus, and angular gyrus compared to healthy subjects. The result from random effects (RFX) on healthy TLE revealed that the left middle frontal gyrus, bilateral superior temporal gyrus, bilateral precuneus, and right supramarginal gyrus were significantly activated but the NOV survive was so small. The findings suggested that TLE patients suffer from impairment in some DMN region, which may cause certain neuropsychological and cognitive degradation. 2020 Conference or Workshop Item NonPeerReviewed text en http://eprints.unisza.edu.my/1930/1/FH03-FP-20-39282.pdf Shuhada, J.M. and Husbani, M.A.R. and A I A, Hamid and Muhammad, A.R. (2020) Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result. In: IOP Conference Series: Materials Science and Engineering, 29-31 Oct 2019, UKM, Bangi.
institution	Universiti Sultan Zainal Abidin
building	UNISZA Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Sultan Zainal Abidin
content_source	UNISZA Institutional Repository
url_provider	https://eprints.unisza.edu.my/
language	English
topic	R Medicine (General) RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle	R Medicine (General) RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Shuhada, J.M. Husbani, M.A.R. A I A, Hamid Muhammad, A.R. Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result
description	The default mode network (DMN) is thought to be impaired in epileptic patients, where the functional integrity of its core regions compromised. Fourteen healthy participants and fourteen aged and gender-matched patients with temporal lobe epilepsy (TLE) took part in this study. The resting-state fMRI (rsfMRI) imaging protocol was executed using a 3-T Phillips Achieva MRI scanner at the Department of Radiology, HUSM. The TLE patient displays decreased activation clusters in precuneus and supramarginal gyrus compared to the healthy group. However increased activation clusters were found on middle frontal gyrus, superior temporal gyrus, and angular gyrus compared to healthy subjects. The result from random effects (RFX) on healthy TLE revealed that the left middle frontal gyrus, bilateral superior temporal gyrus, bilateral precuneus, and right supramarginal gyrus were significantly activated but the NOV survive was so small. The findings suggested that TLE patients suffer from impairment in some DMN region, which may cause certain neuropsychological and cognitive degradation.
format	Conference or Workshop Item
author	Shuhada, J.M. Husbani, M.A.R. A I A, Hamid Muhammad, A.R.
author_facet	Shuhada, J.M. Husbani, M.A.R. A I A, Hamid Muhammad, A.R.
author_sort	Shuhada, J.M.
title	Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result
title_short	Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result
title_full	Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result
title_fullStr	Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result
title_full_unstemmed	Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result
title_sort	evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result
publishDate	2020
url	http://eprints.unisza.edu.my/1930/1/FH03-FP-20-39282.pdf http://eprints.unisza.edu.my/1930/
_version_	1684657774539046912
score	13.211869

Evaluation of default mode network in temporal lobe epilepsy patients and healthy subjects: a preliminary result

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