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Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl

Angiogenesis has an important role in the invasion, metastasis and growth of tumors. Increased microvessel density (MVD) has been described in oral squamous cell carcinoma (OSCC) compared to oral dysplasia and normal oral tissue. A morphometric study was designed to evaluate the MVD and to evaluat...

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Main Authors: Zeng, Zhou Tan, Mohammad Zakir Hossain,, MD Shahidul Ahsan,, Yew, Choy Chew, Swe, Swe Win, Suan, Phaik Khoo
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2016
Online Access:http://journalarticle.ukm.my/9673/1/06_Zeng_Zhou_Tan.pdf
http://journalarticle.ukm.my/9673/
http://www.ukm.my/jsm/malay_journals/jilid45bil2_2016/KandunganJilid45Bil2_2016.html
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spelling my-ukm.journal.96732016-12-14T06:50:30Z http://journalarticle.ukm.my/9673/ Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl Zeng, Zhou Tan Mohammad Zakir Hossain, MD Shahidul Ahsan, Yew, Choy Chew Swe, Swe Win Suan, Phaik Khoo Angiogenesis has an important role in the invasion, metastasis and growth of tumors. Increased microvessel density (MVD) has been described in oral squamous cell carcinoma (OSCC) compared to oral dysplasia and normal oral tissue. A morphometric study was designed to evaluate the MVD and to evaluate the presence of any association between MVD and keratin pearl in the three histopathological grades of OSCC (as defined in Bryne’s grading system). Forty-five samples of OSCC were graded into well differentiated (WDSCC), moderately differentiated (MDSCC) and poorly-differentiated (PDSCC) oral squamous cell carcinoma. Morphometric analysis showed that MVD was significantly lower in WDSCC compared to MDSCC (p<0.001) and PDSCC (p<0.001). The density in MDSCC was significant lower than PDSCC. The keratin pearl count was significantly higher in WDSCC compared to MDSCC (p<0.001) and PDSCC (p<0.001). Between MDSCC and PDSCC, the keratin pearl count was significantly higher for MDSCC (p=0.001). Pearson correlation test showed a significant negative correlation between keratin pearl and MVD (r=-0.805, p<0.001). The findings suggested that vascularity in OSCC is associated with its cellular differentiation and also associated with keratin pearl formation. Universiti Kebangsaan Malaysia 2016-02 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9673/1/06_Zeng_Zhou_Tan.pdf Zeng, Zhou Tan and Mohammad Zakir Hossain, and MD Shahidul Ahsan, and Yew, Choy Chew and Swe, Swe Win and Suan, Phaik Khoo (2016) Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl. Sains Malaysiana, 45 (2). pp. 201-205. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid45bil2_2016/KandunganJilid45Bil2_2016.html
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Angiogenesis has an important role in the invasion, metastasis and growth of tumors. Increased microvessel density (MVD) has been described in oral squamous cell carcinoma (OSCC) compared to oral dysplasia and normal oral tissue. A morphometric study was designed to evaluate the MVD and to evaluate the presence of any association between MVD and keratin pearl in the three histopathological grades of OSCC (as defined in Bryne’s grading system). Forty-five samples of OSCC were graded into well differentiated (WDSCC), moderately differentiated (MDSCC) and poorly-differentiated (PDSCC) oral squamous cell carcinoma. Morphometric analysis showed that MVD was significantly lower in WDSCC compared to MDSCC (p<0.001) and PDSCC (p<0.001). The density in MDSCC was significant lower than PDSCC. The keratin pearl count was significantly higher in WDSCC compared to MDSCC (p<0.001) and PDSCC (p<0.001). Between MDSCC and PDSCC, the keratin pearl count was significantly higher for MDSCC (p=0.001). Pearson correlation test showed a significant negative correlation between keratin pearl and MVD (r=-0.805, p<0.001). The findings suggested that vascularity in OSCC is associated with its cellular differentiation and also associated with keratin pearl formation.
format Article
author Zeng, Zhou Tan
Mohammad Zakir Hossain,
MD Shahidul Ahsan,
Yew, Choy Chew
Swe, Swe Win
Suan, Phaik Khoo
spellingShingle Zeng, Zhou Tan
Mohammad Zakir Hossain,
MD Shahidul Ahsan,
Yew, Choy Chew
Swe, Swe Win
Suan, Phaik Khoo
Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
author_facet Zeng, Zhou Tan
Mohammad Zakir Hossain,
MD Shahidul Ahsan,
Yew, Choy Chew
Swe, Swe Win
Suan, Phaik Khoo
author_sort Zeng, Zhou Tan
title Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
title_short Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
title_full Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
title_fullStr Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
title_full_unstemmed Microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
title_sort microvessel density in different grades of oral squamous cell carcinoma and its relationship with keratin pearl
publisher Universiti Kebangsaan Malaysia
publishDate 2016
url http://journalarticle.ukm.my/9673/1/06_Zeng_Zhou_Tan.pdf
http://journalarticle.ukm.my/9673/
http://www.ukm.my/jsm/malay_journals/jilid45bil2_2016/KandunganJilid45Bil2_2016.html
_version_ 1643737861951848448
score 13.211869

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