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Kesan in vitro rilmenidine ke atas rembesan insulin

This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak...

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Main Authors: Rosnani Hashim,, Tariq Abdul Razak,, Suhaimi Hashim,
Format: Article
Language:English
Published: penerbit ukm 2003
Online Access:http://journalarticle.ukm.my/948/1/jurnal4.pdf
http://journalarticle.ukm.my/948/
http://www.fskb.ukm.my/fskbold/jurnal
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spelling my-ukm.journal.9482016-12-14T06:28:23Z http://journalarticle.ukm.my/948/ Kesan in vitro rilmenidine ke atas rembesan insulin Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations. penerbit ukm 2003-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/948/1/jurnal4.pdf Rosnani Hashim, and Tariq Abdul Razak, and Suhaimi Hashim, (2003) Kesan in vitro rilmenidine ke atas rembesan insulin. Jurnal Sains Kesihatan Malaysia, 1 . pp. 1-7. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations.
format Article
author Rosnani Hashim,
Tariq Abdul Razak,
Suhaimi Hashim,
spellingShingle Rosnani Hashim,
Tariq Abdul Razak,
Suhaimi Hashim,
Kesan in vitro rilmenidine ke atas rembesan insulin
author_facet Rosnani Hashim,
Tariq Abdul Razak,
Suhaimi Hashim,
author_sort Rosnani Hashim,
title Kesan in vitro rilmenidine ke atas rembesan insulin
title_short Kesan in vitro rilmenidine ke atas rembesan insulin
title_full Kesan in vitro rilmenidine ke atas rembesan insulin
title_fullStr Kesan in vitro rilmenidine ke atas rembesan insulin
title_full_unstemmed Kesan in vitro rilmenidine ke atas rembesan insulin
title_sort kesan in vitro rilmenidine ke atas rembesan insulin
publisher penerbit ukm
publishDate 2003
url http://journalarticle.ukm.my/948/1/jurnal4.pdf
http://journalarticle.ukm.my/948/
http://www.fskb.ukm.my/fskbold/jurnal
_version_ 1643734851238494208
score 13.211869

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