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Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane

This was a prospective randomised study comparing carboxyhaemoglobin concentrations between low-flow anaesthesia (fresh gas flow 1.0 L/min) and minimal-flow anaesthesia (0.5 L/min) using desflurane. Sixty (ASA 1 or 2) adult patients undergoing elective surgery under general anaesthesia were randomly...

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Main Authors: Nazarudin B.,, Khairulamir Z.,, Azarinah I.,, Jaafar MZ.,, Karis M.,, Esa K.,
Format: Article
Language:English
Published: Department of Surgery, UKM Medical Centre 2015
Online Access:http://journalarticle.ukm.my/8651/1/04-Nazarudin%2520B%2520et%2520al..pdf
http://journalarticle.ukm.my/8651/
http://jsurgical.com
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spelling my-ukm.journal.86512016-12-14T06:47:47Z http://journalarticle.ukm.my/8651/ Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane Nazarudin B., Khairulamir Z., Azarinah I., Jaafar MZ., Karis M., Esa K., This was a prospective randomised study comparing carboxyhaemoglobin concentrations between low-flow anaesthesia (fresh gas flow 1.0 L/min) and minimal-flow anaesthesia (0.5 L/min) using desflurane. Sixty (ASA 1 or 2) adult patients undergoing elective surgery under general anaesthesia were randomly allocated to receive either low-flow (Group 1) or minimal flow anaesthesia (Group 2). Venous blood samples for carboxyhaemoglobin levels were taken at baseline and at 10 mins intervals for 40 mins. Both groups showed significant increase in carboxyhaemoglobin concentrations within the first 10 mins when fresh gas flow of 4.0 L/min was used. Reduction in carboxyhemoglobin levels was seen after 20 mins of minimal or low flow anaesthesia. However, there was no significant difference in the magnitude of reduction of carboxyhemoglobin concentrations between the groups. The fractional inspired of oxygen (FiO2) showed no significant changes in either group. In conclusion, desflurane usage in anaesthesia with either low-flow or minimal-flow was not associated with increased carboxyhaemoglobin concentrations. Department of Surgery, UKM Medical Centre 2015-06-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8651/1/04-Nazarudin%2520B%2520et%2520al..pdf Nazarudin B., and Khairulamir Z., and Azarinah I., and Jaafar MZ., and Karis M., and Esa K., (2015) Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane. Journal of Surgical Academia, vol.5 (1). pp. 19-23. ISSN 2231-7481 http://jsurgical.com
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description This was a prospective randomised study comparing carboxyhaemoglobin concentrations between low-flow anaesthesia (fresh gas flow 1.0 L/min) and minimal-flow anaesthesia (0.5 L/min) using desflurane. Sixty (ASA 1 or 2) adult patients undergoing elective surgery under general anaesthesia were randomly allocated to receive either low-flow (Group 1) or minimal flow anaesthesia (Group 2). Venous blood samples for carboxyhaemoglobin levels were taken at baseline and at 10 mins intervals for 40 mins. Both groups showed significant increase in carboxyhaemoglobin concentrations within the first 10 mins when fresh gas flow of 4.0 L/min was used. Reduction in carboxyhemoglobin levels was seen after 20 mins of minimal or low flow anaesthesia. However, there was no significant difference in the magnitude of reduction of carboxyhemoglobin concentrations between the groups. The fractional inspired of oxygen (FiO2) showed no significant changes in either group. In conclusion, desflurane usage in anaesthesia with either low-flow or minimal-flow was not associated with increased carboxyhaemoglobin concentrations.
format Article
author Nazarudin B.,
Khairulamir Z.,
Azarinah I.,
Jaafar MZ.,
Karis M.,
Esa K.,
spellingShingle Nazarudin B.,
Khairulamir Z.,
Azarinah I.,
Jaafar MZ.,
Karis M.,
Esa K.,
Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
author_facet Nazarudin B.,
Khairulamir Z.,
Azarinah I.,
Jaafar MZ.,
Karis M.,
Esa K.,
author_sort Nazarudin B.,
title Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
title_short Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
title_full Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
title_fullStr Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
title_full_unstemmed Comparison of Carboxyhaemoglobin Concentrations between Low-flow and Minimal-flow Anaesthesia with Desflurane
title_sort comparison of carboxyhaemoglobin concentrations between low-flow and minimal-flow anaesthesia with desflurane
publisher Department of Surgery, UKM Medical Centre
publishDate 2015
url http://journalarticle.ukm.my/8651/1/04-Nazarudin%2520B%2520et%2520al..pdf
http://journalarticle.ukm.my/8651/
http://jsurgical.com
_version_ 1643737539306061824
score 13.211869

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