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Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets

The use of sustained release tablet formulation for non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin has shown its capability to protect the stomach lining from the adverse effect of gastric juice from the body. This study was carried out to evaluate the efficiency of sustained release ma...

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Main Authors: Ibrahim Ijang,, Mohd Cairul Iqbal Mohd Amin,, Bukhori Abu Bakar,
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2010
Online Access:http://journalarticle.ukm.my/7398/1/01_Md_Yeaminhossain.pdf
http://journalarticle.ukm.my/7398/
http://www.ukm.my/jsm/english_journals/vol39num5_2010/contentsVol39num5_2010.html
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spelling my-ukm.journal.73982016-12-14T06:43:57Z http://journalarticle.ukm.my/7398/ Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets Ibrahim Ijang, Mohd Cairul Iqbal Mohd Amin, Bukhori Abu Bakar, The use of sustained release tablet formulation for non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin has shown its capability to protect the stomach lining from the adverse effect of gastric juice from the body. This study was carried out to evaluate the efficiency of sustained release matrix tablet formulation using ketoprofen as a model drug with different polymers concentration. The tablets were prepared by the wet granulation method using hydrophilic polymer (hydroxypropyl methylcellulose), hydrophobic pH dependent polymer (Eudragit L100-55) and independent polymer (Eudragit RD 100) as matrix forming retarding materials at 10%w/w, 20%w/w and 30%w/w. All formulations were compressed using 10 mm concave faced punches. The compressed tablets were evaluated for uniformity of weight, friability, hardness, thickness, % drug content and in vitro dissolution test with regard to BP 2007. The results showed that the drug release rate was found to be governed by the type and concentration of polymer in the matrix system. Generally, increasing the polymeric concentration in the matrix tablets will decrease the rate of drug release. When the polymers were compared at similar concentration using t50%, the difference in drug release was found to be statistically significant (p<0.05). Based on the in vitro drug dissolution studies, the hydrophobic pH dependent polymer (Eudragit L100-55) showed a better zero drug release profile compared to other polymers. Universiti Kebangsaan Malaysia 2010-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/7398/1/01_Md_Yeaminhossain.pdf Ibrahim Ijang, and Mohd Cairul Iqbal Mohd Amin, and Bukhori Abu Bakar, (2010) Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets. Sains Malaysiana, 39 (5). pp. 737-745. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol39num5_2010/contentsVol39num5_2010.html
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The use of sustained release tablet formulation for non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin has shown its capability to protect the stomach lining from the adverse effect of gastric juice from the body. This study was carried out to evaluate the efficiency of sustained release matrix tablet formulation using ketoprofen as a model drug with different polymers concentration. The tablets were prepared by the wet granulation method using hydrophilic polymer (hydroxypropyl methylcellulose), hydrophobic pH dependent polymer (Eudragit L100-55) and independent polymer (Eudragit RD 100) as matrix forming retarding materials at 10%w/w, 20%w/w and 30%w/w. All formulations were compressed using 10 mm concave faced punches. The compressed tablets were evaluated for uniformity of weight, friability, hardness, thickness, % drug content and in vitro dissolution test with regard to BP 2007. The results showed that the drug release rate was found to be governed by the type and concentration of polymer in the matrix system. Generally, increasing the polymeric concentration in the matrix tablets will decrease the rate of drug release. When the polymers were compared at similar concentration using t50%, the difference in drug release was found to be statistically significant (p<0.05). Based on the in vitro drug dissolution studies, the hydrophobic pH dependent polymer (Eudragit L100-55) showed a better zero drug release profile compared to other polymers.
format Article
author Ibrahim Ijang,
Mohd Cairul Iqbal Mohd Amin,
Bukhori Abu Bakar,
spellingShingle Ibrahim Ijang,
Mohd Cairul Iqbal Mohd Amin,
Bukhori Abu Bakar,
Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
author_facet Ibrahim Ijang,
Mohd Cairul Iqbal Mohd Amin,
Bukhori Abu Bakar,
author_sort Ibrahim Ijang,
title Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
title_short Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
title_full Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
title_fullStr Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
title_full_unstemmed Physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
title_sort physical properties and in vitro studies of sustained-release ketoprofen matrix tablets
publisher Universiti Kebangsaan Malaysia
publishDate 2010
url http://journalarticle.ukm.my/7398/1/01_Md_Yeaminhossain.pdf
http://journalarticle.ukm.my/7398/
http://www.ukm.my/jsm/english_journals/vol39num5_2010/contentsVol39num5_2010.html
_version_ 1643737113155338240
score 13.211869

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