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Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits

It is of interest that seeds and pericarps of tropical fruits contain phytochemicals being the components of various biological activities for beneficial health effects. This study was aimed to evaluate antioxidant and anticancer activities of the methanolic extracts from seeds and pericarps of thre...

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Main Authors: Warangkana Chunglok,, Tanyarath Utaipan,, Nathnarin Somchit,, Monthon Lertcanawanichakul,, Yuttana Sudjaroen,
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2014
Online Access:http://journalarticle.ukm.my/7149/1/06_Warangkana_Chunglok.pdf
http://journalarticle.ukm.my/7149/
http://www.ukm.my/jsm/
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spelling my-ukm.journal.71492016-12-14T06:43:14Z http://journalarticle.ukm.my/7149/ Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits Warangkana Chunglok, Tanyarath Utaipan, Nathnarin Somchit, Monthon Lertcanawanichakul, Yuttana Sudjaroen, It is of interest that seeds and pericarps of tropical fruits contain phytochemicals being the components of various biological activities for beneficial health effects. This study was aimed to evaluate antioxidant and anticancer activities of the methanolic extracts from seeds and pericarps of three selected tropical fruits including Rambutan (Nephelium lappaceum L.), Litchi (Litchi chinensis Sonn.) and Tamarind (Tamarindus indica L.). Total phenolic content was determined by using the Folin-Ciocalteu method. Antioxidant capacity was evaluated based on the ability of the fruit extracts to scavenge ABTS and DPPH radicals. MTT reduction assay and Annexin V-FITC/PI staining were carried out for cytotoxicity and apoptosis induction, respectively. Total phenolic contents of the seeds and pericarps of the tropical fruits ranged from 104.60 to 501.95 mg/g DW. All extracts were found to have significant antioxidant activities. Among them, tamarind seed extract contained the highest total phenolic contents and possessed the highest antioxidant capacities. Tamarind seed extract showed the highest cytotoxicity to human mouth carcinoma (CLS-354) cells and had no toxicity to PBMCs. Staining with annexin V-FITC/PI showed that this apoptosis occurred early in this cell type with 10.0% of the cells undergoing apoptosis. Tamarind seed extract might have potential anticancer activity which could be attributed, in part, to selectively inhibit the growth of CLS-354 cells and induce apoptosis. This research finding would be valuable information to identify major constituents of the extracts and mechanisms underlying anticancer activity which could be attributed to dietary health supplements or cancer chemoprevention from fruits. Universiti Kebangsaan Malaysia 2014-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/7149/1/06_Warangkana_Chunglok.pdf Warangkana Chunglok, and Tanyarath Utaipan, and Nathnarin Somchit, and Monthon Lertcanawanichakul, and Yuttana Sudjaroen, (2014) Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits. Sains Malaysiana, 43 (5). pp. 689-695. ISSN 0126-6039 http://www.ukm.my/jsm/
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description It is of interest that seeds and pericarps of tropical fruits contain phytochemicals being the components of various biological activities for beneficial health effects. This study was aimed to evaluate antioxidant and anticancer activities of the methanolic extracts from seeds and pericarps of three selected tropical fruits including Rambutan (Nephelium lappaceum L.), Litchi (Litchi chinensis Sonn.) and Tamarind (Tamarindus indica L.). Total phenolic content was determined by using the Folin-Ciocalteu method. Antioxidant capacity was evaluated based on the ability of the fruit extracts to scavenge ABTS and DPPH radicals. MTT reduction assay and Annexin V-FITC/PI staining were carried out for cytotoxicity and apoptosis induction, respectively. Total phenolic contents of the seeds and pericarps of the tropical fruits ranged from 104.60 to 501.95 mg/g DW. All extracts were found to have significant antioxidant activities. Among them, tamarind seed extract contained the highest total phenolic contents and possessed the highest antioxidant capacities. Tamarind seed extract showed the highest cytotoxicity to human mouth carcinoma (CLS-354) cells and had no toxicity to PBMCs. Staining with annexin V-FITC/PI showed that this apoptosis occurred early in this cell type with 10.0% of the cells undergoing apoptosis. Tamarind seed extract might have potential anticancer activity which could be attributed, in part, to selectively inhibit the growth of CLS-354 cells and induce apoptosis. This research finding would be valuable information to identify major constituents of the extracts and mechanisms underlying anticancer activity which could be attributed to dietary health supplements or cancer chemoprevention from fruits.
format Article
author Warangkana Chunglok,
Tanyarath Utaipan,
Nathnarin Somchit,
Monthon Lertcanawanichakul,
Yuttana Sudjaroen,
spellingShingle Warangkana Chunglok,
Tanyarath Utaipan,
Nathnarin Somchit,
Monthon Lertcanawanichakul,
Yuttana Sudjaroen,
Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits
author_facet Warangkana Chunglok,
Tanyarath Utaipan,
Nathnarin Somchit,
Monthon Lertcanawanichakul,
Yuttana Sudjaroen,
author_sort Warangkana Chunglok,
title Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits
title_short Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits
title_full Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits
title_fullStr Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits
title_full_unstemmed Antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits
title_sort antioxidant and antiproliferative activities of non-edible parts of selected tropical fruits
publisher Universiti Kebangsaan Malaysia
publishDate 2014
url http://journalarticle.ukm.my/7149/1/06_Warangkana_Chunglok.pdf
http://journalarticle.ukm.my/7149/
http://www.ukm.my/jsm/
_version_ 1643737023422398464
score 13.211869

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