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Single nucleotide polymorphism for certain genes involved in gestational diabetes with risk factors and complications positive

Gestational Diabetes Mellitus (GDM) is associated with pregnancy complications, however its mechanism has not been fully understood. The aim of this study was to investigate the single nucleotide polymorphism (SNP) for identifying candidate genes involve in risk factors and complications of GDM. A t...

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Main Authors: Nor Azlin Mohamed Ismail,, Norkhatijah Mohd Aris,, Zaleha Abdullah Mahdy,, Shuhaila Ahmad,, Norzilawati Mohd Naim,, Harlina Harlizah Siraj,, Rohana Jaafar,, Shareena Ishak,, Roslan Harun,, Abd Rahman Abd Jamal,, Wan Zurinah Wan Ngah,, Syed Zulkifli Syed Zakaria,
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2013
Online Access:http://journalarticle.ukm.my/6626/1/11_Nor_Azlin.pdf
http://journalarticle.ukm.my/6626/
http://www.ukm.my/jsm/
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spelling my-ukm.journal.66262016-12-14T06:41:44Z http://journalarticle.ukm.my/6626/ Single nucleotide polymorphism for certain genes involved in gestational diabetes with risk factors and complications positive Nor Azlin Mohamed Ismail, Norkhatijah Mohd Aris, Zaleha Abdullah Mahdy, Shuhaila Ahmad, Norzilawati Mohd Naim, Harlina Harlizah Siraj, Rohana Jaafar, Shareena Ishak, Roslan Harun, Abd Rahman Abd Jamal, Wan Zurinah Wan Ngah, Syed Zulkifli Syed Zakaria, Gestational Diabetes Mellitus (GDM) is associated with pregnancy complications, however its mechanism has not been fully understood. The aim of this study was to investigate the single nucleotide polymorphism (SNP) for identifying candidate genes involve in risk factors and complications of GDM. A total of 174 pregnant women with GDM and 114 healthy pregnant women were genotyped with 384 SNPs from 236 genes. The SNPs identified were rs10946398 (CDKAL1) in GDM risk factors; rs328 (LPL) and rs1042778 (OXTR) in complications of caesarean section; rs5404 (SLC2A2), rs5400 (SLC2A2) and rs13306465 (IRS1) for neonatal intensive care admission. Whereby SNPs rs12255372, rs7901695 and rs7903146 from TCF7L2 gene had six times higher risk (OR, 6.40-6.53) for T2DM at postpartum. In conclusion, although the above SNPs were identified with GDM risk factors and complications among pregnant Malaysian women with GDM, a larger study is needed to ascertain this candidate genes actual association. Universiti Kebangsaan Malaysia 2013-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6626/1/11_Nor_Azlin.pdf Nor Azlin Mohamed Ismail, and Norkhatijah Mohd Aris, and Zaleha Abdullah Mahdy, and Shuhaila Ahmad, and Norzilawati Mohd Naim, and Harlina Harlizah Siraj, and Rohana Jaafar, and Shareena Ishak, and Roslan Harun, and Abd Rahman Abd Jamal, and Wan Zurinah Wan Ngah, and Syed Zulkifli Syed Zakaria, (2013) Single nucleotide polymorphism for certain genes involved in gestational diabetes with risk factors and complications positive. Sains Malaysiana, 42 (11). pp. 1613-1618. ISSN 0126-6039 http://www.ukm.my/jsm/
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Gestational Diabetes Mellitus (GDM) is associated with pregnancy complications, however its mechanism has not been fully understood. The aim of this study was to investigate the single nucleotide polymorphism (SNP) for identifying candidate genes involve in risk factors and complications of GDM. A total of 174 pregnant women with GDM and 114 healthy pregnant women were genotyped with 384 SNPs from 236 genes. The SNPs identified were rs10946398 (CDKAL1) in GDM risk factors; rs328 (LPL) and rs1042778 (OXTR) in complications of caesarean section; rs5404 (SLC2A2), rs5400 (SLC2A2) and rs13306465 (IRS1) for neonatal intensive care admission. Whereby SNPs rs12255372, rs7901695 and rs7903146 from TCF7L2 gene had six times higher risk (OR, 6.40-6.53) for T2DM at postpartum. In conclusion, although the above SNPs were identified with GDM risk factors and complications among pregnant Malaysian women with GDM, a larger study is needed to ascertain this candidate genes actual association.
format Article
author Nor Azlin Mohamed Ismail,
Norkhatijah Mohd Aris,
Zaleha Abdullah Mahdy,
Shuhaila Ahmad,
Norzilawati Mohd Naim,
Harlina Harlizah Siraj,
Rohana Jaafar,
Shareena Ishak,
Roslan Harun,
Abd Rahman Abd Jamal,
Wan Zurinah Wan Ngah,
Syed Zulkifli Syed Zakaria,
spellingShingle Nor Azlin Mohamed Ismail,
Norkhatijah Mohd Aris,
Zaleha Abdullah Mahdy,
Shuhaila Ahmad,
Norzilawati Mohd Naim,
Harlina Harlizah Siraj,
Rohana Jaafar,
Shareena Ishak,
Roslan Harun,
Abd Rahman Abd Jamal,
Wan Zurinah Wan Ngah,
Syed Zulkifli Syed Zakaria,
Single nucleotide polymorphism for certain genes involved in gestational diabetes with risk factors and complications positive
author_facet Nor Azlin Mohamed Ismail,
Norkhatijah Mohd Aris,
Zaleha Abdullah Mahdy,
Shuhaila Ahmad,
Norzilawati Mohd Naim,
Harlina Harlizah Siraj,
Rohana Jaafar,
Shareena Ishak,
Roslan Harun,
Abd Rahman Abd Jamal,
Wan Zurinah Wan Ngah,
Syed Zulkifli Syed Zakaria,
author_sort Nor Azlin Mohamed Ismail,
title Single nucleotide polymorphism for certain genes involved in gestational diabetes with risk factors and complications positive
title_short Single nucleotide polymorphism for certain genes involved in gestational diabetes with risk factors and complications positive
title_full Single nucleotide polymorphism for certain genes involved in gestational diabetes with risk factors and complications positive
title_fullStr Single nucleotide polymorphism for certain genes involved in gestational diabetes with risk factors and complications positive
title_full_unstemmed Single nucleotide polymorphism for certain genes involved in gestational diabetes with risk factors and complications positive
title_sort single nucleotide polymorphism for certain genes involved in gestational diabetes with risk factors and complications positive
publisher Universiti Kebangsaan Malaysia
publishDate 2013
url http://journalarticle.ukm.my/6626/1/11_Nor_Azlin.pdf
http://journalarticle.ukm.my/6626/
http://www.ukm.my/jsm/
_version_ 1643736839064911872
score 13.211869

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