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Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats

Cosmos caudatus or ‘ulam raja’ is a local plant with antioxidant properties and has the potential to treat free radicals-associated diseases. However, its toxic effects need to be elucidated. Acute toxicity study was carried out in male rats. Rats aged 3 months, weighing 150-200 g were divided into...

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Main Authors: M. Norazlina,, S.Z., Ehsan, K., Noor 'Adilah, C.P., Lee, E., Farhana, P., Derick, S., Ima-Nirwana, A.S., Nazrun, M., Norliza
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2013
Online Access:http://journalarticle.ukm.my/6466/1/06_M._Norazlina.pdf
http://journalarticle.ukm.my/6466/
http://www.ukm.my/jsm/
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spelling my-ukm.journal.64662016-12-14T06:41:15Z http://journalarticle.ukm.my/6466/ Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats M. Norazlina, S.Z., Ehsan K., Noor 'Adilah C.P., Lee E., Farhana P., Derick S., Ima-Nirwana A.S., Nazrun M., Norliza Cosmos caudatus or ‘ulam raja’ is a local plant with antioxidant properties and has the potential to treat free radicals-associated diseases. However, its toxic effects need to be elucidated. Acute toxicity study was carried out in male rats. Rats aged 3 months, weighing 150-200 g were divided into 4 groups, i.e. rats being fed on distilled water (control), Cosmos caudatus extract dose 50 mg/kg (CC50), Cosmos caudatus 500 mg/kg (CC500) and Cosmos caudatus 2000 mg/kg (CC2000), respectively. A single treatment was given to the respective groups and the animals were sacrificed after 7 days. Biochemical parameters before and after treatment were measured. Liver enzymes, i.e. alkaline phosphatase (ALP) and alanine transaminase (ALT), were found to be increased post treatment in CC500 and CC2000 groups. Creatinine levels were lower in CC500 and CC2000 groups post treatment compared with control group while albumin levels were lower in CC2000 group than all the other groups. In conclusion, Cosmos caudatus may cause acute hepatotoxicity at high doses. Universiti Kebangsaan Malaysia 2013-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6466/1/06_M._Norazlina.pdf M. Norazlina, and S.Z., Ehsan and K., Noor 'Adilah and C.P., Lee and E., Farhana and P., Derick and S., Ima-Nirwana and A.S., Nazrun and M., Norliza (2013) Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats. Sains Malaysiana, 42 (9). pp. 1237-1246. ISSN 0126-6039 http://www.ukm.my/jsm/
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Cosmos caudatus or ‘ulam raja’ is a local plant with antioxidant properties and has the potential to treat free radicals-associated diseases. However, its toxic effects need to be elucidated. Acute toxicity study was carried out in male rats. Rats aged 3 months, weighing 150-200 g were divided into 4 groups, i.e. rats being fed on distilled water (control), Cosmos caudatus extract dose 50 mg/kg (CC50), Cosmos caudatus 500 mg/kg (CC500) and Cosmos caudatus 2000 mg/kg (CC2000), respectively. A single treatment was given to the respective groups and the animals were sacrificed after 7 days. Biochemical parameters before and after treatment were measured. Liver enzymes, i.e. alkaline phosphatase (ALP) and alanine transaminase (ALT), were found to be increased post treatment in CC500 and CC2000 groups. Creatinine levels were lower in CC500 and CC2000 groups post treatment compared with control group while albumin levels were lower in CC2000 group than all the other groups. In conclusion, Cosmos caudatus may cause acute hepatotoxicity at high doses.
format Article
author M. Norazlina,
S.Z., Ehsan
K., Noor 'Adilah
C.P., Lee
E., Farhana
P., Derick
S., Ima-Nirwana
A.S., Nazrun
M., Norliza
spellingShingle M. Norazlina,
S.Z., Ehsan
K., Noor 'Adilah
C.P., Lee
E., Farhana
P., Derick
S., Ima-Nirwana
A.S., Nazrun
M., Norliza
Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
author_facet M. Norazlina,
S.Z., Ehsan
K., Noor 'Adilah
C.P., Lee
E., Farhana
P., Derick
S., Ima-Nirwana
A.S., Nazrun
M., Norliza
author_sort M. Norazlina,
title Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
title_short Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
title_full Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
title_fullStr Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
title_full_unstemmed Acute toxicity study of cosmos caudatus on Biochemical Parameters in Male Rats
title_sort acute toxicity study of cosmos caudatus on biochemical parameters in male rats
publisher Universiti Kebangsaan Malaysia
publishDate 2013
url http://journalarticle.ukm.my/6466/1/06_M._Norazlina.pdf
http://journalarticle.ukm.my/6466/
http://www.ukm.my/jsm/
_version_ 1643736780579536896
score 13.211869

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