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Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats

Abundant natural products with medicinal properties have been used as food and traditional medicine for diabetes mellitus all over the world. Psidium guajava fruit from the family of Myrtaceae has gained attention for its antioxidant potential. This study was conducted to determine the effects of P....

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Main Authors: Siti Balkis Budin,, Hawa Ismail,, Pek, Lian Chong
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2013
Online Access:http://journalarticle.ukm.my/6273/1/02_Siti_Balkis.pdf
http://journalarticle.ukm.my/6273/
http://www.ukm.my/jsm/
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spelling my-ukm.journal.62732016-12-14T06:40:42Z http://journalarticle.ukm.my/6273/ Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats Siti Balkis Budin, Hawa Ismail, Pek, Lian Chong Abundant natural products with medicinal properties have been used as food and traditional medicine for diabetes mellitus all over the world. Psidium guajava fruit from the family of Myrtaceae has gained attention for its antioxidant potential. This study was conducted to determine the effects of P. guajava fruit peel aqueous extract on oxidative stress of pancreas in streptozotocin-induced (45 mg/kg) diabetic rats. Diabetic rats were administered with 400 mg/kg of aqueous extract of P. guajava fruit peel daily for 28 days duration. The results showed that diabetic rats supplemented with P. guajava extract did not cause significant difference in blood glucose level (p>0.05) as compared with diabetic rats alone. For oxidative stress evaluation, malondialdehyde (MDA) and protein carbonyl level were significantly lower and the activity of superoxide dismutase (SOD) and glutathione (GSH) level were significantly higher (p<0.05) in P. guajava supplemented rats compared with non-supplemented diabetic rats. However, histological observation showed that supplementation of P. guajava extract did not give protective effects towards alterations in pancreas histology in diabetic rats. The findings suggested that aqueous extract of P. guajava fruit peel supplementation has the ability to reduce oxidative stress in pancreas of diabetic rats and may play a role in reducing the development of diabetic complications. Universiti Kebangsaan Malaysia 2013-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/6273/1/02_Siti_Balkis.pdf Siti Balkis Budin, and Hawa Ismail, and Pek, Lian Chong (2013) Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats. Sains Malaysiana, 42 (6). pp. 707-713. ISSN 0126-6039 http://www.ukm.my/jsm/
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Abundant natural products with medicinal properties have been used as food and traditional medicine for diabetes mellitus all over the world. Psidium guajava fruit from the family of Myrtaceae has gained attention for its antioxidant potential. This study was conducted to determine the effects of P. guajava fruit peel aqueous extract on oxidative stress of pancreas in streptozotocin-induced (45 mg/kg) diabetic rats. Diabetic rats were administered with 400 mg/kg of aqueous extract of P. guajava fruit peel daily for 28 days duration. The results showed that diabetic rats supplemented with P. guajava extract did not cause significant difference in blood glucose level (p>0.05) as compared with diabetic rats alone. For oxidative stress evaluation, malondialdehyde (MDA) and protein carbonyl level were significantly lower and the activity of superoxide dismutase (SOD) and glutathione (GSH) level were significantly higher (p<0.05) in P. guajava supplemented rats compared with non-supplemented diabetic rats. However, histological observation showed that supplementation of P. guajava extract did not give protective effects towards alterations in pancreas histology in diabetic rats. The findings suggested that aqueous extract of P. guajava fruit peel supplementation has the ability to reduce oxidative stress in pancreas of diabetic rats and may play a role in reducing the development of diabetic complications.
format Article
author Siti Balkis Budin,
Hawa Ismail,
Pek, Lian Chong
spellingShingle Siti Balkis Budin,
Hawa Ismail,
Pek, Lian Chong
Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
author_facet Siti Balkis Budin,
Hawa Ismail,
Pek, Lian Chong
author_sort Siti Balkis Budin,
title Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
title_short Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
title_full Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
title_fullStr Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
title_full_unstemmed Psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
title_sort psidium guajava fruit peel extract reduces oxidative stress of pancreas in streptozotocin-induced diabetic rats
publisher Universiti Kebangsaan Malaysia
publishDate 2013
url http://journalarticle.ukm.my/6273/1/02_Siti_Balkis.pdf
http://journalarticle.ukm.my/6273/
http://www.ukm.my/jsm/
_version_ 1643736706975793152
score 13.211869

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