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Some studies into the effects of metaldehyde on cultured cells

Metaldehyde is used widely in Malaysia for the control of molluscs. This communication reports the cytotoxic effects of this chemical on cultured cells as assessed by cell morphology and the DNA synthesing capability as well as its transport into cells. After 15 days of exposure with 20.0 ppm of the...

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Main Authors: Salmijah Surif,, Anita Mohd. Zubir,, Maimon Abdullah,
Format: Article
Published: Universiti Kebangsaan Malaysia 1997
Online Access:http://journalarticle.ukm.my/3734/
http://www.ukm.my/jsm/english_journals/vol26num1_1997/vol26num1_97page103-109.html
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spelling my-ukm.journal.37342012-03-16T08:09:43Z http://journalarticle.ukm.my/3734/ Some studies into the effects of metaldehyde on cultured cells Salmijah Surif, Anita Mohd. Zubir, Maimon Abdullah, Metaldehyde is used widely in Malaysia for the control of molluscs. This communication reports the cytotoxic effects of this chemical on cultured cells as assessed by cell morphology and the DNA synthesing capability as well as its transport into cells. After 15 days of exposure with 20.0 ppm of the compound, the DNA synthesising capability was shown to be unaffected. The IC50 for Vero cells was 276.0 ppm. Transport of thymidine across cells was found to be not significantly affected even at high metaldehyde concentrations (up to 320.0 ppm) suggesting integrity of cells were not significantly affected. The present cellular studies have therefore shown that the cytotoxic effects of this chemical is rather low. Universiti Kebangsaan Malaysia 1997-03 Article PeerReviewed Salmijah Surif, and Anita Mohd. Zubir, and Maimon Abdullah, (1997) Some studies into the effects of metaldehyde on cultured cells. Sains Malaysiana, 26 (1). pp. 103-109. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol26num1_1997/vol26num1_97page103-109.html
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
description Metaldehyde is used widely in Malaysia for the control of molluscs. This communication reports the cytotoxic effects of this chemical on cultured cells as assessed by cell morphology and the DNA synthesing capability as well as its transport into cells. After 15 days of exposure with 20.0 ppm of the compound, the DNA synthesising capability was shown to be unaffected. The IC50 for Vero cells was 276.0 ppm. Transport of thymidine across cells was found to be not significantly affected even at high metaldehyde concentrations (up to 320.0 ppm) suggesting integrity of cells were not significantly affected. The present cellular studies have therefore shown that the cytotoxic effects of this chemical is rather low.
format Article
author Salmijah Surif,
Anita Mohd. Zubir,
Maimon Abdullah,
spellingShingle Salmijah Surif,
Anita Mohd. Zubir,
Maimon Abdullah,
Some studies into the effects of metaldehyde on cultured cells
author_facet Salmijah Surif,
Anita Mohd. Zubir,
Maimon Abdullah,
author_sort Salmijah Surif,
title Some studies into the effects of metaldehyde on cultured cells
title_short Some studies into the effects of metaldehyde on cultured cells
title_full Some studies into the effects of metaldehyde on cultured cells
title_fullStr Some studies into the effects of metaldehyde on cultured cells
title_full_unstemmed Some studies into the effects of metaldehyde on cultured cells
title_sort some studies into the effects of metaldehyde on cultured cells
publisher Universiti Kebangsaan Malaysia
publishDate 1997
url http://journalarticle.ukm.my/3734/
http://www.ukm.my/jsm/english_journals/vol26num1_1997/vol26num1_97page103-109.html
_version_ 1643735830819241984
score 13.211869

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