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Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer

Para-methoxy cinnamic acid (pMCA) is a derivative compound of ethyl p-methoxycinnamate that could be obtained in nature. pMCA has excellent pharmacological properties. However, in their application as a drug, pMCA has poor water solubility. In this present research, we try to increase the water solu...

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Main Authors: Sulistyowaty, Melanny Ika, Fitri, Suciati, Yuliati, Ninis, Amrillah, Tahta, Che Azurahanim Che Abdullah,, Setyawan, Dwi
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2024
Online Access:http://journalarticle.ukm.my/24810/1/SMS%2017.pdf
http://journalarticle.ukm.my/24810/
https://www.ukm.my/jsm/english_journals/vol53num10_2024/contentsVol53num10_2024.html
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spelling my-ukm.journal.248102025-02-05T08:08:48Z http://journalarticle.ukm.my/24810/ Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer Sulistyowaty, Melanny Ika Fitri, Suciati Yuliati, Ninis Amrillah, Tahta Che Azurahanim Che Abdullah, Setyawan, Dwi Para-methoxy cinnamic acid (pMCA) is a derivative compound of ethyl p-methoxycinnamate that could be obtained in nature. pMCA has excellent pharmacological properties. However, in their application as a drug, pMCA has poor water solubility. In this present research, we try to increase the water solubility of pMCA using the cocrystal formation (cocrystallization) strategy. Here, we use caffeine as a coformer that can interact very well with pMCA via non-covalent bonding and Van der Waals interaction to achieve cocrystal formation. The cocrystal samples were successfully synthesized using various synthesis techniques; physical mixture, solvent evaporation, and microwave radiation methods. It shows that the solubility of the samples synthesized using microwave-assisted and solvent evaporation increases about 3.30 and 3.12 times, respectively, whereas the dissolution rate profile increases 2.50 and 2.39 times, respectively, compared to pure APMS. Our findings explain the importance of the cocrystal formation strategy to enhance the solubility of active material pMCA. This strategy can also be used as a standard formulation of a new drug system with excellent solubility and dissolution which is very important for the pharmaceutical industry. Penerbit Universiti Kebangsaan Malaysia 2024 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/24810/1/SMS%2017.pdf Sulistyowaty, Melanny Ika and Fitri, Suciati and Yuliati, Ninis and Amrillah, Tahta and Che Azurahanim Che Abdullah, and Setyawan, Dwi (2024) Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer. Sains Malaysiana, 53 (10). pp. 3445-3454. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol53num10_2024/contentsVol53num10_2024.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Para-methoxy cinnamic acid (pMCA) is a derivative compound of ethyl p-methoxycinnamate that could be obtained in nature. pMCA has excellent pharmacological properties. However, in their application as a drug, pMCA has poor water solubility. In this present research, we try to increase the water solubility of pMCA using the cocrystal formation (cocrystallization) strategy. Here, we use caffeine as a coformer that can interact very well with pMCA via non-covalent bonding and Van der Waals interaction to achieve cocrystal formation. The cocrystal samples were successfully synthesized using various synthesis techniques; physical mixture, solvent evaporation, and microwave radiation methods. It shows that the solubility of the samples synthesized using microwave-assisted and solvent evaporation increases about 3.30 and 3.12 times, respectively, whereas the dissolution rate profile increases 2.50 and 2.39 times, respectively, compared to pure APMS. Our findings explain the importance of the cocrystal formation strategy to enhance the solubility of active material pMCA. This strategy can also be used as a standard formulation of a new drug system with excellent solubility and dissolution which is very important for the pharmaceutical industry.
format Article
author Sulistyowaty, Melanny Ika
Fitri, Suciati
Yuliati, Ninis
Amrillah, Tahta
Che Azurahanim Che Abdullah,
Setyawan, Dwi
spellingShingle Sulistyowaty, Melanny Ika
Fitri, Suciati
Yuliati, Ninis
Amrillah, Tahta
Che Azurahanim Che Abdullah,
Setyawan, Dwi
Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer
author_facet Sulistyowaty, Melanny Ika
Fitri, Suciati
Yuliati, Ninis
Amrillah, Tahta
Che Azurahanim Che Abdullah,
Setyawan, Dwi
author_sort Sulistyowaty, Melanny Ika
title Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer
title_short Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer
title_full Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer
title_fullStr Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer
title_full_unstemmed Solubility and dissolutıon improvement of paramethoxycinnamic acid (pMCA) induced by cocrystal formation using caffeine as a coformer
title_sort solubility and dissolutıon improvement of paramethoxycinnamic acid (pmca) induced by cocrystal formation using caffeine as a coformer
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2024
url http://journalarticle.ukm.my/24810/1/SMS%2017.pdf
http://journalarticle.ukm.my/24810/
https://www.ukm.my/jsm/english_journals/vol53num10_2024/contentsVol53num10_2024.html
_version_ 1823274791831863296
score 13.239859

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