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Determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model

The characteristics of early and advanced stages of diabetic cardiomyopathy (DCM) are well-understood; however, the time points by which these stages are developed in animal models vary and depend on the hyperglycaemic status and duration of diabetes. This study was aimed to determine the time point...

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Main Authors: Fatin Farhana Jubaidi,, Nur Liyana Mohammed Yusof,, Satirah Zainalabidin,, Izatus Shima Taib,, Zariyantey Abd Hamid,, Siti Balkis Budin,, ,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2024
Online Access:http://journalarticle.ukm.my/24122/1/SME%208.pdf
http://journalarticle.ukm.my/24122/
https://www.ukm.my/jsm/english_journals/vol53num6_2024/contentsVol53num6_2024.html
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spelling my-ukm.journal.241222024-09-05T04:28:07Z http://journalarticle.ukm.my/24122/ Determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model Fatin Farhana Jubaidi, Nur Liyana Mohammed Yusof, Satirah Zainalabidin, Izatus Shima Taib, Zariyantey Abd Hamid, Siti Balkis Budin, , The characteristics of early and advanced stages of diabetic cardiomyopathy (DCM) are well-understood; however, the time points by which these stages are developed in animal models vary and depend on the hyperglycaemic status and duration of diabetes. This study was aimed to determine the time points for the development of early and advanced stages of DCM from the induction of type 1 diabetes mellitus by identifying the functional and histological changes that occurred. Type 1 diabetes was induced via streptozotocin injection, and rats were divided into 4-week and 8-week diabetic groups. A group of non-diabetic rats served as the normal control. Cardiac functions and structural changes were analysed. Results showed that after four weeks, all diabetic rats displayed early DCM characteristics, including pronounced left ventricular diastolic dysfunction and cardiomyocyte hypertrophy (P < 0.05) compared to the normal control. After eight weeks, there was a significant deterioration in both left ventricular systolic and diastolic function compared to the normal control, along with marked cardiomyocyte hypertrophy and myocardial fibrosis (P < 0.05), signifying the development of advanced DCM. In summary, this findings revealed the development of early and advanced stages of DCM at four weeks and eight weeks of diabetes respectively in diabetes melitus type 1 rat model. Penerbit Universiti Kebangsaan Malaysia 2024 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/24122/1/SME%208.pdf Fatin Farhana Jubaidi, and Nur Liyana Mohammed Yusof, and Satirah Zainalabidin, and Izatus Shima Taib, and Zariyantey Abd Hamid, and Siti Balkis Budin, and UNSPECIFIED (2024) Determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model. Sains Malaysiana, 53 (6). pp. 1321-1332. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol53num6_2024/contentsVol53num6_2024.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The characteristics of early and advanced stages of diabetic cardiomyopathy (DCM) are well-understood; however, the time points by which these stages are developed in animal models vary and depend on the hyperglycaemic status and duration of diabetes. This study was aimed to determine the time points for the development of early and advanced stages of DCM from the induction of type 1 diabetes mellitus by identifying the functional and histological changes that occurred. Type 1 diabetes was induced via streptozotocin injection, and rats were divided into 4-week and 8-week diabetic groups. A group of non-diabetic rats served as the normal control. Cardiac functions and structural changes were analysed. Results showed that after four weeks, all diabetic rats displayed early DCM characteristics, including pronounced left ventricular diastolic dysfunction and cardiomyocyte hypertrophy (P < 0.05) compared to the normal control. After eight weeks, there was a significant deterioration in both left ventricular systolic and diastolic function compared to the normal control, along with marked cardiomyocyte hypertrophy and myocardial fibrosis (P < 0.05), signifying the development of advanced DCM. In summary, this findings revealed the development of early and advanced stages of DCM at four weeks and eight weeks of diabetes respectively in diabetes melitus type 1 rat model.
format Article
author Fatin Farhana Jubaidi,
Nur Liyana Mohammed Yusof,
Satirah Zainalabidin,
Izatus Shima Taib,
Zariyantey Abd Hamid,
Siti Balkis Budin,
,
spellingShingle Fatin Farhana Jubaidi,
Nur Liyana Mohammed Yusof,
Satirah Zainalabidin,
Izatus Shima Taib,
Zariyantey Abd Hamid,
Siti Balkis Budin,
,
Determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model
author_facet Fatin Farhana Jubaidi,
Nur Liyana Mohammed Yusof,
Satirah Zainalabidin,
Izatus Shima Taib,
Zariyantey Abd Hamid,
Siti Balkis Budin,
,
author_sort Fatin Farhana Jubaidi,
title Determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model
title_short Determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model
title_full Determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model
title_fullStr Determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model
title_full_unstemmed Determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model
title_sort determining the time points for the development of early and advanced stages of diabetic cardiomyopathy in streptozotocin-induced type 1 diabetes mellitus rat model
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2024
url http://journalarticle.ukm.my/24122/1/SME%208.pdf
http://journalarticle.ukm.my/24122/
https://www.ukm.my/jsm/english_journals/vol53num6_2024/contentsVol53num6_2024.html
_version_ 1811683408184606720
score 13.211869

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