Staff View: Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats

Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats

WHO estimates that between 48 million couples and 186 million individuals are facing infertility globally. Male infertility contributes to one-third of the problem with oligospermia as a primary underlying cause. Edible bird nest (EBN), a nutritional natural product, has the potential to improve mal...

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Main Authors:	Nurul Atiqah Azhar,, Khairul Osman,, Farah Hanan Fathihah Jaffar,, Chua, Kien Hui, Mohd Farisyam Mat Ros,, Aini Farzana Zulkefli,, Siti Fatimah Ibrahim,
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2024
Online Access:	http://journalarticle.ukm.my/24044/1/SEE%2018.pdf http://journalarticle.ukm.my/24044/ https://www.ukm.my/jsm/english_journals/vol53num5_2024/contentsVol53num5_2024.html
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spelling	my-ukm.journal.240442024-08-19T05:26:13Z http://journalarticle.ukm.my/24044/ Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats Nurul Atiqah Azhar, Khairul Osman, Farah Hanan Fathihah Jaffar, Chua, Kien Hui Mohd Farisyam Mat Ros, Aini Farzana Zulkefli, Siti Fatimah Ibrahim, WHO estimates that between 48 million couples and 186 million individuals are facing infertility globally. Male infertility contributes to one-third of the problem with oligospermia as a primary underlying cause. Edible bird nest (EBN), a nutritional natural product, has the potential to improve male fertility status. However, the scientific evidence on oligospermia is sparse. Therefore, this study aimed to evaluate the effectiveness of EBN supplementation in busulfan-induced oligospermia of adult rats. Thirty-six eight-week-old Sprague Dawley male rats (N=36) were randomly and equally divided into six groups (n=6): Control, Sham, Busulfan, EBN 250, 500, and 1000 mg/ kg/daily. A single dose of 10 mg/kg busulfan was injected intraperitoneally to induce oligospermia. Daily EBN supplementation was administered for 28 consecutive days, started one day following the busulfan injection. Findings showed that sperm concentration, spermatogenesis index scoring, seminiferous tubule diameter, and germ cell height were reduced in busulfan-induced oligospermia. Meanwhile, the apoptosis status was significantly increased. EBN supplementation had significantly increased sperm concentration, spermatogenesis index scoring, germ cell height, and gene expression of p38 and MAPK14. EBN supplementation also reduced apoptosis in the oligospermia group in a dose-dependent manner. In conclusion, daily EBN supplementation has a protective effect in busulfan-induced oligospermia by increasing sperm production, preserving histological features of the testes, reducing apoptosis, and improving gene expression of p38 and MAPK14. Penerbit Universiti Kebangsaan Malaysia 2024 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/24044/1/SEE%2018.pdf Nurul Atiqah Azhar, and Khairul Osman, and Farah Hanan Fathihah Jaffar, and Chua, Kien Hui and Mohd Farisyam Mat Ros, and Aini Farzana Zulkefli, and Siti Fatimah Ibrahim, (2024) Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats. Sains Malaysiana, 53 (5). pp. 1219-1234. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol53num5_2024/contentsVol53num5_2024.html
institution	Universiti Kebangsaan Malaysia
building	Tun Sri Lanang Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Kebangsaan Malaysia
content_source	UKM Journal Article Repository
url_provider	http://journalarticle.ukm.my/
language	English
description	WHO estimates that between 48 million couples and 186 million individuals are facing infertility globally. Male infertility contributes to one-third of the problem with oligospermia as a primary underlying cause. Edible bird nest (EBN), a nutritional natural product, has the potential to improve male fertility status. However, the scientific evidence on oligospermia is sparse. Therefore, this study aimed to evaluate the effectiveness of EBN supplementation in busulfan-induced oligospermia of adult rats. Thirty-six eight-week-old Sprague Dawley male rats (N=36) were randomly and equally divided into six groups (n=6): Control, Sham, Busulfan, EBN 250, 500, and 1000 mg/ kg/daily. A single dose of 10 mg/kg busulfan was injected intraperitoneally to induce oligospermia. Daily EBN supplementation was administered for 28 consecutive days, started one day following the busulfan injection. Findings showed that sperm concentration, spermatogenesis index scoring, seminiferous tubule diameter, and germ cell height were reduced in busulfan-induced oligospermia. Meanwhile, the apoptosis status was significantly increased. EBN supplementation had significantly increased sperm concentration, spermatogenesis index scoring, germ cell height, and gene expression of p38 and MAPK14. EBN supplementation also reduced apoptosis in the oligospermia group in a dose-dependent manner. In conclusion, daily EBN supplementation has a protective effect in busulfan-induced oligospermia by increasing sperm production, preserving histological features of the testes, reducing apoptosis, and improving gene expression of p38 and MAPK14.
format	Article
author	Nurul Atiqah Azhar, Khairul Osman, Farah Hanan Fathihah Jaffar, Chua, Kien Hui Mohd Farisyam Mat Ros, Aini Farzana Zulkefli, Siti Fatimah Ibrahim,
spellingShingle	Nurul Atiqah Azhar, Khairul Osman, Farah Hanan Fathihah Jaffar, Chua, Kien Hui Mohd Farisyam Mat Ros, Aini Farzana Zulkefli, Siti Fatimah Ibrahim, Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats
author_facet	Nurul Atiqah Azhar, Khairul Osman, Farah Hanan Fathihah Jaffar, Chua, Kien Hui Mohd Farisyam Mat Ros, Aini Farzana Zulkefli, Siti Fatimah Ibrahim,
author_sort	Nurul Atiqah Azhar,
title	Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats
title_short	Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats
title_full	Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats
title_fullStr	Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats
title_full_unstemmed	Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats
title_sort	effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2024
url	http://journalarticle.ukm.my/24044/1/SEE%2018.pdf http://journalarticle.ukm.my/24044/ https://www.ukm.my/jsm/english_journals/vol53num5_2024/contentsVol53num5_2024.html
_version_	1809139049806430208
score	13.211869

Effect of edible bird nest supplementation against busulfan-induced oligospermia in adult rats

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