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Proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model

This study was conducted to evaluate the effect of Paederia scandens on high-fat dietinduced non-alcoholic fatty liver disease (NAFLD) in a rat model and further show the therapeutic mechanisms of Paederia scandens. Thirty rats weighing 180 ± 12 g (6 weeks old) were randomly divided into three group...

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Main Authors: Wang, Jing, Tong, Tiejin, Wu, Qiang
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2024
Online Access:http://journalarticle.ukm.my/23741/1/SMT%208.pdf
http://journalarticle.ukm.my/23741/
https://www.ukm.my/jsm/english_journals/vol53num3_2024/contentsVol53num3_2024.html
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spelling my-ukm.journal.237412024-07-02T04:39:48Z http://journalarticle.ukm.my/23741/ Proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model Wang, Jing Tong, Tiejin Wu, Qiang This study was conducted to evaluate the effect of Paederia scandens on high-fat dietinduced non-alcoholic fatty liver disease (NAFLD) in a rat model and further show the therapeutic mechanisms of Paederia scandens. Thirty rats weighing 180 ± 12 g (6 weeks old) were randomly divided into three groups: A control group (CG), a high-fat diet model group (HF), and a Paederia scandens intervention group (PS). After 45 days, the rats’ serum lipid metabolism, liver injury parameters, and liver proteomics were detected. The results indicated that dietary Paederia scandens significantly reduced the levels of triglycerides, total cholesterol, glucose, and low-density lipoprotein cholesterol in the NAFLD rats compared with those in the HF group. Meanwhile, decreased levels of alanine aminotransferase and aspartate transaminase were observed in rats of the PS group. In addition, 382 differentially abundant proteins were identified between the HF and PS groups. Protein-protein interaction network analysis identified 14 keystone proteins that might play critical roles in ameliorating NAFLD. In particular, Paederia scandens treatment significantly upregulated the levels of Hadh, Hadhb, Acadl, Acox1, Acox3, Cyp3a2, and Cyp1a1, which are involved in fatty acid βoxidation, PPAR, and cytochrome P450 signaling pathways. Hence, the data demonstrated that Paederia scandens ameliorates hepatic lipid accumulation and impairment by enhancing fatty acid β-oxidation and activating PPAR and cytochrome P450 signaling pathways. These data provide new insights into the treatment of NAFLD and suggest the potential of Paederia scandens as an effective therapy. Penerbit Universiti Kebangsaan Malaysia 2024 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/23741/1/SMT%208.pdf Wang, Jing and Tong, Tiejin and Wu, Qiang (2024) Proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model. Sains Malaysiana, 53 (3). pp. 575-589. ISSN 0126-6039 https://www.ukm.my/jsm/english_journals/vol53num3_2024/contentsVol53num3_2024.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description This study was conducted to evaluate the effect of Paederia scandens on high-fat dietinduced non-alcoholic fatty liver disease (NAFLD) in a rat model and further show the therapeutic mechanisms of Paederia scandens. Thirty rats weighing 180 ± 12 g (6 weeks old) were randomly divided into three groups: A control group (CG), a high-fat diet model group (HF), and a Paederia scandens intervention group (PS). After 45 days, the rats’ serum lipid metabolism, liver injury parameters, and liver proteomics were detected. The results indicated that dietary Paederia scandens significantly reduced the levels of triglycerides, total cholesterol, glucose, and low-density lipoprotein cholesterol in the NAFLD rats compared with those in the HF group. Meanwhile, decreased levels of alanine aminotransferase and aspartate transaminase were observed in rats of the PS group. In addition, 382 differentially abundant proteins were identified between the HF and PS groups. Protein-protein interaction network analysis identified 14 keystone proteins that might play critical roles in ameliorating NAFLD. In particular, Paederia scandens treatment significantly upregulated the levels of Hadh, Hadhb, Acadl, Acox1, Acox3, Cyp3a2, and Cyp1a1, which are involved in fatty acid βoxidation, PPAR, and cytochrome P450 signaling pathways. Hence, the data demonstrated that Paederia scandens ameliorates hepatic lipid accumulation and impairment by enhancing fatty acid β-oxidation and activating PPAR and cytochrome P450 signaling pathways. These data provide new insights into the treatment of NAFLD and suggest the potential of Paederia scandens as an effective therapy.
format Article
author Wang, Jing
Tong, Tiejin
Wu, Qiang
spellingShingle Wang, Jing
Tong, Tiejin
Wu, Qiang
Proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model
author_facet Wang, Jing
Tong, Tiejin
Wu, Qiang
author_sort Wang, Jing
title Proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model
title_short Proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model
title_full Proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model
title_fullStr Proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model
title_full_unstemmed Proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model
title_sort proteomics shows the role of paederia scandens in ameliorating non-alcoholic fatty liver disease in a rat model
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2024
url http://journalarticle.ukm.my/23741/1/SMT%208.pdf
http://journalarticle.ukm.my/23741/
https://www.ukm.my/jsm/english_journals/vol53num3_2024/contentsVol53num3_2024.html
_version_ 1804066002918440960
score 13.211869

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