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The relationship between intraocular pressure and estimated intracranial pressure in patients with normal tension glaucoma

This study aims to determine the relationship between intracranial pressure (ICP) and intraocular pressure (IOP) in patients with normal-tension glaucoma (NTG) who were already on anti-glaucoma treatment using an estimated ICP (estICP) and translaminar pressure difference (estTPD) formula. A cross-s...

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Main Authors: MS, Syamil, AN, Rona, CH, Jemaima
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2023
Online Access:http://journalarticle.ukm.my/22550/1/m%26h_4.pdf
http://journalarticle.ukm.my/22550/
https://www.medicineandhealthukm.com/toc/18/1
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spelling my-ukm.journal.225502023-11-30T06:18:48Z http://journalarticle.ukm.my/22550/ The relationship between intraocular pressure and estimated intracranial pressure in patients with normal tension glaucoma MS, Syamil AN, Rona CH, Jemaima This study aims to determine the relationship between intracranial pressure (ICP) and intraocular pressure (IOP) in patients with normal-tension glaucoma (NTG) who were already on anti-glaucoma treatment using an estimated ICP (estICP) and translaminar pressure difference (estTPD) formula. A cross-sectional comparative study consisted of 66 subjects (66 eyes) who were divided into NTG (n=33) and normal (n=33) group was conducted from 1st November 2017 until 31st May 2020 at a tertiary hospital in Malaysia. After obtaining consent from subjects, ocular and systemic data including IOP, visual field testing, axial length, central corneal thickness (CCT), peripapillary and macular retinal nerve fibre layer evaluation as well as blood pressure (BP) and body mass index (BMI) were collected. The estICP (mm Hg) was calculated as 0.44 x BMI (kg/m2) + 0.16 x diastolic blood pressure (mmHg) – 0.18 x age (years) – 1.91. The estTPD was derived from this calculated value, where estTPD (mm Hg) = IOP – estICP. Analysis showed there was no significant difference in estimated ICP between NTG and normal subjects [mean difference (95% CI): 0.37 (-1.39, 2.12), p=0.679]. The difference in estTPD between NTG and normal subjects were found to be statistically insignificant too [mean difference (95% CI): -1.24 (-2.95, 0.47), p=0.149]. The variables significant in multivariate model included best corrected visual acuity (p=0.028), retinal nerve fiber layer (RNFL) (p=0.003), average macular (p=0.002) and estTPD (p=0.008). The EstTPD was found to be protective towards NTG, which the unit increased in estTPD will decreased the odds of having NTG by 26.5% [Adj. OR (95% CI): 0.735 (0.586, 0.922), p=0.008]. In conclusion, ICP was correlated in increased in IOP. A higher TPD may be associated with a lower chance of developing NTG. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/22550/1/m%26h_4.pdf MS, Syamil and AN, Rona and CH, Jemaima (2023) The relationship between intraocular pressure and estimated intracranial pressure in patients with normal tension glaucoma. Medicine & Health, 18 (1). pp. 46-58. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/18/1
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description This study aims to determine the relationship between intracranial pressure (ICP) and intraocular pressure (IOP) in patients with normal-tension glaucoma (NTG) who were already on anti-glaucoma treatment using an estimated ICP (estICP) and translaminar pressure difference (estTPD) formula. A cross-sectional comparative study consisted of 66 subjects (66 eyes) who were divided into NTG (n=33) and normal (n=33) group was conducted from 1st November 2017 until 31st May 2020 at a tertiary hospital in Malaysia. After obtaining consent from subjects, ocular and systemic data including IOP, visual field testing, axial length, central corneal thickness (CCT), peripapillary and macular retinal nerve fibre layer evaluation as well as blood pressure (BP) and body mass index (BMI) were collected. The estICP (mm Hg) was calculated as 0.44 x BMI (kg/m2) + 0.16 x diastolic blood pressure (mmHg) – 0.18 x age (years) – 1.91. The estTPD was derived from this calculated value, where estTPD (mm Hg) = IOP – estICP. Analysis showed there was no significant difference in estimated ICP between NTG and normal subjects [mean difference (95% CI): 0.37 (-1.39, 2.12), p=0.679]. The difference in estTPD between NTG and normal subjects were found to be statistically insignificant too [mean difference (95% CI): -1.24 (-2.95, 0.47), p=0.149]. The variables significant in multivariate model included best corrected visual acuity (p=0.028), retinal nerve fiber layer (RNFL) (p=0.003), average macular (p=0.002) and estTPD (p=0.008). The EstTPD was found to be protective towards NTG, which the unit increased in estTPD will decreased the odds of having NTG by 26.5% [Adj. OR (95% CI): 0.735 (0.586, 0.922), p=0.008]. In conclusion, ICP was correlated in increased in IOP. A higher TPD may be associated with a lower chance of developing NTG.
format Article
author MS, Syamil
AN, Rona
CH, Jemaima
spellingShingle MS, Syamil
AN, Rona
CH, Jemaima
The relationship between intraocular pressure and estimated intracranial pressure in patients with normal tension glaucoma
author_facet MS, Syamil
AN, Rona
CH, Jemaima
author_sort MS, Syamil
title The relationship between intraocular pressure and estimated intracranial pressure in patients with normal tension glaucoma
title_short The relationship between intraocular pressure and estimated intracranial pressure in patients with normal tension glaucoma
title_full The relationship between intraocular pressure and estimated intracranial pressure in patients with normal tension glaucoma
title_fullStr The relationship between intraocular pressure and estimated intracranial pressure in patients with normal tension glaucoma
title_full_unstemmed The relationship between intraocular pressure and estimated intracranial pressure in patients with normal tension glaucoma
title_sort relationship between intraocular pressure and estimated intracranial pressure in patients with normal tension glaucoma
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2023
url http://journalarticle.ukm.my/22550/1/m%26h_4.pdf
http://journalarticle.ukm.my/22550/
https://www.medicineandhealthukm.com/toc/18/1
_version_ 1784512998909411328
score 13.211869

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