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Change in immune biomarkers of laboratory mice responding to experimental inoculation of different drinking water quality from selected dairy farms

Current knowledge of abnormal physiological responses in livestock due to consumption of substandard water is limited. This study was designed to explore the host cell responses in mice orally inoculated with different drinking water qualities from selected dairy cattle farms. A total of 28 female m...

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Main Authors: Faez Firdaus Abdullah Jesse,, Nagachandra Rao Gopi Naidu,, Paul, Bura Thlama, Lim, Eric Teik Chung, Wan Lutfi Wan Johari,, Abba, Yusuf, Mohd Azmi Mohd Lila,, Mohd Jefri Norsidin,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2023
Online Access:http://journalarticle.ukm.my/22505/1/MAS%203.pdf
http://journalarticle.ukm.my/22505/
https://jms.mabjournal.com/index.php/mab/index
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spelling my-ukm.journal.225052023-11-20T07:36:45Z http://journalarticle.ukm.my/22505/ Change in immune biomarkers of laboratory mice responding to experimental inoculation of different drinking water quality from selected dairy farms Faez Firdaus Abdullah Jesse, Nagachandra Rao Gopi Naidu, Paul, Bura Thlama Lim, Eric Teik Chung Wan Lutfi Wan Johari, Abba, Yusuf Mohd Azmi Mohd Lila, Mohd Jefri Norsidin, Current knowledge of abnormal physiological responses in livestock due to consumption of substandard water is limited. This study was designed to explore the host cell responses in mice orally inoculated with different drinking water qualities from selected dairy cattle farms. A total of 28 female mice used in this study were divided into Group 1- negative control (treated with sterile deionized distilled water), Group 2 - treated with good quality water sample, Group 3 - treated with moderate quality water sample, and Group 4 - treated with unsatisfactory quality water sample. All the mice were given 0.25 mL of water samples three times daily for 30 days. Blood samples were collected from all mice before euthanasia at 30 days post-inoculation for reproductive hormones and biomarkers analyses. All treatment groups showed significant (p<0.05) weight loss compared to the control group. There was a significant difference in the serum immunoglobulin-G (IgG), , immunoglobulin-M (IgM), interleukin-12 (IL-12), haptoglobin (Hp), and serum amyloid A (SAA) profiles of mice among the different water quality treatments as compared to the control group (p<0.05). In conclusion, the host cell responses exhibited by the mice in the treatment groups indicates a high risk of potential negative effect on the production and health of the livestock due to long-term consumption of drinking water with subpar quality. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/22505/1/MAS%203.pdf Faez Firdaus Abdullah Jesse, and Nagachandra Rao Gopi Naidu, and Paul, Bura Thlama and Lim, Eric Teik Chung and Wan Lutfi Wan Johari, and Abba, Yusuf and Mohd Azmi Mohd Lila, and Mohd Jefri Norsidin, (2023) Change in immune biomarkers of laboratory mice responding to experimental inoculation of different drinking water quality from selected dairy farms. Malaysian Applied Biology, 52 (3). pp. 23-28. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/index
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Current knowledge of abnormal physiological responses in livestock due to consumption of substandard water is limited. This study was designed to explore the host cell responses in mice orally inoculated with different drinking water qualities from selected dairy cattle farms. A total of 28 female mice used in this study were divided into Group 1- negative control (treated with sterile deionized distilled water), Group 2 - treated with good quality water sample, Group 3 - treated with moderate quality water sample, and Group 4 - treated with unsatisfactory quality water sample. All the mice were given 0.25 mL of water samples three times daily for 30 days. Blood samples were collected from all mice before euthanasia at 30 days post-inoculation for reproductive hormones and biomarkers analyses. All treatment groups showed significant (p<0.05) weight loss compared to the control group. There was a significant difference in the serum immunoglobulin-G (IgG), , immunoglobulin-M (IgM), interleukin-12 (IL-12), haptoglobin (Hp), and serum amyloid A (SAA) profiles of mice among the different water quality treatments as compared to the control group (p<0.05). In conclusion, the host cell responses exhibited by the mice in the treatment groups indicates a high risk of potential negative effect on the production and health of the livestock due to long-term consumption of drinking water with subpar quality.
format Article
author Faez Firdaus Abdullah Jesse,
Nagachandra Rao Gopi Naidu,
Paul, Bura Thlama
Lim, Eric Teik Chung
Wan Lutfi Wan Johari,
Abba, Yusuf
Mohd Azmi Mohd Lila,
Mohd Jefri Norsidin,
spellingShingle Faez Firdaus Abdullah Jesse,
Nagachandra Rao Gopi Naidu,
Paul, Bura Thlama
Lim, Eric Teik Chung
Wan Lutfi Wan Johari,
Abba, Yusuf
Mohd Azmi Mohd Lila,
Mohd Jefri Norsidin,
Change in immune biomarkers of laboratory mice responding to experimental inoculation of different drinking water quality from selected dairy farms
author_facet Faez Firdaus Abdullah Jesse,
Nagachandra Rao Gopi Naidu,
Paul, Bura Thlama
Lim, Eric Teik Chung
Wan Lutfi Wan Johari,
Abba, Yusuf
Mohd Azmi Mohd Lila,
Mohd Jefri Norsidin,
author_sort Faez Firdaus Abdullah Jesse,
title Change in immune biomarkers of laboratory mice responding to experimental inoculation of different drinking water quality from selected dairy farms
title_short Change in immune biomarkers of laboratory mice responding to experimental inoculation of different drinking water quality from selected dairy farms
title_full Change in immune biomarkers of laboratory mice responding to experimental inoculation of different drinking water quality from selected dairy farms
title_fullStr Change in immune biomarkers of laboratory mice responding to experimental inoculation of different drinking water quality from selected dairy farms
title_full_unstemmed Change in immune biomarkers of laboratory mice responding to experimental inoculation of different drinking water quality from selected dairy farms
title_sort change in immune biomarkers of laboratory mice responding to experimental inoculation of different drinking water quality from selected dairy farms
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2023
url http://journalarticle.ukm.my/22505/1/MAS%203.pdf
http://journalarticle.ukm.my/22505/
https://jms.mabjournal.com/index.php/mab/index
_version_ 1783877709644955648
score 13.211869

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