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Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder

In this study, the new compound 6-amidinoindole 3 were synthesized by hydrogenating the amidoxime unit in a high yield. The compound was characterized by FTIR, 1H NMR, 13C NMR and ESI-MS. The binding of the compound towards heme was evaluated using absorption spectroscopy. The studies found that the...

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Main Authors: Noraisyah Abdul Kadir Jilani,, Oka, Natsuhisa, Ando, Kaori, Siti Aishah Hasbullah,
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2023
Online Access:http://journalarticle.ukm.my/22071/1/SE%2015.pdf
http://journalarticle.ukm.my/22071/
http://www.ukm.my/jsm/index.html
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spelling my-ukm.journal.220712023-08-08T08:54:45Z http://journalarticle.ukm.my/22071/ Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder Noraisyah Abdul Kadir Jilani, Oka, Natsuhisa Ando, Kaori Siti Aishah Hasbullah, In this study, the new compound 6-amidinoindole 3 were synthesized by hydrogenating the amidoxime unit in a high yield. The compound was characterized by FTIR, 1H NMR, 13C NMR and ESI-MS. The binding of the compound towards heme was evaluated using absorption spectroscopy. The studies found that the association constant (log K) is 3.90. The binding strength indicated the ligand’s possibility to interact significantly with heme and acted as a binder to the malaria parasite. In silico hemozoin docking was performed to gain insight into the mode of action. The docked score is -8.3 kcal/mol, indicated the possible inhibition of hemozoin. This study could serve as the basis for the future development of malaria sensors and antiplasmodial activity. Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/22071/1/SE%2015.pdf Noraisyah Abdul Kadir Jilani, and Oka, Natsuhisa and Ando, Kaori and Siti Aishah Hasbullah, (2023) Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder. Sains Malaysiana, 52 (4). pp. 1231-1242. ISSN 0126-6039 http://www.ukm.my/jsm/index.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description In this study, the new compound 6-amidinoindole 3 were synthesized by hydrogenating the amidoxime unit in a high yield. The compound was characterized by FTIR, 1H NMR, 13C NMR and ESI-MS. The binding of the compound towards heme was evaluated using absorption spectroscopy. The studies found that the association constant (log K) is 3.90. The binding strength indicated the ligand’s possibility to interact significantly with heme and acted as a binder to the malaria parasite. In silico hemozoin docking was performed to gain insight into the mode of action. The docked score is -8.3 kcal/mol, indicated the possible inhibition of hemozoin. This study could serve as the basis for the future development of malaria sensors and antiplasmodial activity.
format Article
author Noraisyah Abdul Kadir Jilani,
Oka, Natsuhisa
Ando, Kaori
Siti Aishah Hasbullah,
spellingShingle Noraisyah Abdul Kadir Jilani,
Oka, Natsuhisa
Ando, Kaori
Siti Aishah Hasbullah,
Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder
author_facet Noraisyah Abdul Kadir Jilani,
Oka, Natsuhisa
Ando, Kaori
Siti Aishah Hasbullah,
author_sort Noraisyah Abdul Kadir Jilani,
title Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder
title_short Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder
title_full Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder
title_fullStr Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder
title_full_unstemmed Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder
title_sort synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder
publisher Universiti Kebangsaan Malaysia
publishDate 2023
url http://journalarticle.ukm.my/22071/1/SE%2015.pdf
http://journalarticle.ukm.my/22071/
http://www.ukm.my/jsm/index.html
_version_ 1775623648041762816
score 13.244413

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