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Exploration of Annona muricata (Annonaceae) in the treatment of hyperlipidemia through network pharmacology and molecular docking

Soursop (Annona muricata L.) is one of the plants that have antihyperlipidemic effects, but its underlying mechanism of action remains unknown. Previous investigations used TCMSP, KNApSAcK, ETCM, SwissTargetPrediction, SuperPred, CTD, and TTD to identify potential targets of soursop as antihyperlipi...

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Main Authors: Syahruni, Reny, Umar, Abdul Halim, Rahman, Hindriyani Nurul, Kusuma, Wisnu Ananta
Format: Article
Language:English
Published: Universiti Kebangsaan Malaysia 2023
Online Access:http://journalarticle.ukm.my/21923/1/ST%2017.pdf
http://journalarticle.ukm.my/21923/
http://www.ukm.my/jsm/index.html
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spelling my-ukm.journal.219232023-07-21T04:04:54Z http://journalarticle.ukm.my/21923/ Exploration of Annona muricata (Annonaceae) in the treatment of hyperlipidemia through network pharmacology and molecular docking Syahruni, Reny Umar, Abdul Halim Rahman, Hindriyani Nurul Kusuma, Wisnu Ananta Soursop (Annona muricata L.) is one of the plants that have antihyperlipidemic effects, but its underlying mechanism of action remains unknown. Previous investigations used TCMSP, KNApSAcK, ETCM, SwissTargetPrediction, SuperPred, CTD, and TTD to identify potential targets of soursop as antihyperlipidemic. Therefore, this study aims to explore soursop active compounds and demonstrate their mechanisms against hyperlipidemia through network pharmacology and molecular docking. OB and drug-likeness properties of the compounds from A. muricata were screened based on Lipinski’s Ro5 (Lipinski’s Rule of Five) parameters. Subsequently, the network of the compound–target–disease–pathways was constructed using Cytoscape. The target PPI (protein-protein interaction) network was built using STRING and the core targets were analyzed using GO with KEGG. The main active compounds against the targets were confirmed by molecular docking analysis. Based on the results, 158 compounds were identified in A. muricata, and the human body was found to absorb 56. It was discovered that 20 compounds were associated with cholesterol disease. The highest degree of the disease pathway of target compounds disease was annomuricin, XDH, myocardial ischemia, and metabolic pathways, respectively. The PPI showed GAPDH (glyceraldehyde-3-phosphate dehydrogenase) protein also has the highest degree. BP, CC, MF, and KEEG enrichments that play important roles are the response to drugs, plasma membranes, protein binding, and metabolic pathways. The molecular docking experiment confirmed the correlation between ligands and receptors (quercetin-XDH, coclaurine-ADRB3, fisetin, and robinetin-XDH) with binding energies of –9.3; –8.9; and –8.8 kcal mol–1, respectively. The interactions between ligands and receptors are hydrogen, alkyl, Pi-alkyl, Pi-sigma, and van der Waals bonds. It was discovered that A. muricata provided therapeutic effects, involving multi-compounds, multi-targets, multi-diseases, and multi-pathways as well as deep insight into the pathogenesis of hyperlipidemia. This can be used to design new drugs and develop novel therapies to treat hyperlipidemia. Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21923/1/ST%2017.pdf Syahruni, Reny and Umar, Abdul Halim and Rahman, Hindriyani Nurul and Kusuma, Wisnu Ananta (2023) Exploration of Annona muricata (Annonaceae) in the treatment of hyperlipidemia through network pharmacology and molecular docking. Sains Malaysiana, 52 (3). pp. 899-939. ISSN 0126-6039 http://www.ukm.my/jsm/index.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Soursop (Annona muricata L.) is one of the plants that have antihyperlipidemic effects, but its underlying mechanism of action remains unknown. Previous investigations used TCMSP, KNApSAcK, ETCM, SwissTargetPrediction, SuperPred, CTD, and TTD to identify potential targets of soursop as antihyperlipidemic. Therefore, this study aims to explore soursop active compounds and demonstrate their mechanisms against hyperlipidemia through network pharmacology and molecular docking. OB and drug-likeness properties of the compounds from A. muricata were screened based on Lipinski’s Ro5 (Lipinski’s Rule of Five) parameters. Subsequently, the network of the compound–target–disease–pathways was constructed using Cytoscape. The target PPI (protein-protein interaction) network was built using STRING and the core targets were analyzed using GO with KEGG. The main active compounds against the targets were confirmed by molecular docking analysis. Based on the results, 158 compounds were identified in A. muricata, and the human body was found to absorb 56. It was discovered that 20 compounds were associated with cholesterol disease. The highest degree of the disease pathway of target compounds disease was annomuricin, XDH, myocardial ischemia, and metabolic pathways, respectively. The PPI showed GAPDH (glyceraldehyde-3-phosphate dehydrogenase) protein also has the highest degree. BP, CC, MF, and KEEG enrichments that play important roles are the response to drugs, plasma membranes, protein binding, and metabolic pathways. The molecular docking experiment confirmed the correlation between ligands and receptors (quercetin-XDH, coclaurine-ADRB3, fisetin, and robinetin-XDH) with binding energies of –9.3; –8.9; and –8.8 kcal mol–1, respectively. The interactions between ligands and receptors are hydrogen, alkyl, Pi-alkyl, Pi-sigma, and van der Waals bonds. It was discovered that A. muricata provided therapeutic effects, involving multi-compounds, multi-targets, multi-diseases, and multi-pathways as well as deep insight into the pathogenesis of hyperlipidemia. This can be used to design new drugs and develop novel therapies to treat hyperlipidemia.
format Article
author Syahruni, Reny
Umar, Abdul Halim
Rahman, Hindriyani Nurul
Kusuma, Wisnu Ananta
spellingShingle Syahruni, Reny
Umar, Abdul Halim
Rahman, Hindriyani Nurul
Kusuma, Wisnu Ananta
Exploration of Annona muricata (Annonaceae) in the treatment of hyperlipidemia through network pharmacology and molecular docking
author_facet Syahruni, Reny
Umar, Abdul Halim
Rahman, Hindriyani Nurul
Kusuma, Wisnu Ananta
author_sort Syahruni, Reny
title Exploration of Annona muricata (Annonaceae) in the treatment of hyperlipidemia through network pharmacology and molecular docking
title_short Exploration of Annona muricata (Annonaceae) in the treatment of hyperlipidemia through network pharmacology and molecular docking
title_full Exploration of Annona muricata (Annonaceae) in the treatment of hyperlipidemia through network pharmacology and molecular docking
title_fullStr Exploration of Annona muricata (Annonaceae) in the treatment of hyperlipidemia through network pharmacology and molecular docking
title_full_unstemmed Exploration of Annona muricata (Annonaceae) in the treatment of hyperlipidemia through network pharmacology and molecular docking
title_sort exploration of annona muricata (annonaceae) in the treatment of hyperlipidemia through network pharmacology and molecular docking
publisher Universiti Kebangsaan Malaysia
publishDate 2023
url http://journalarticle.ukm.my/21923/1/ST%2017.pdf
http://journalarticle.ukm.my/21923/
http://www.ukm.my/jsm/index.html
_version_ 1772812463768600576
score 13.211869

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