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Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis

Parasitic gastroenteritis (PGE) is a significant disease that affects small ruminant production. PGE is controlled exclusively by chemical anthelmintics but restricted by anthelmintic resistance. Hence, dependence on anthelmintics needs to be reduced. This study aimed to investigate the anthelmintic...

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Main Authors: Noor Al Majidah Abd Majid,, Muhammad Iqbal Ishak,, Jagathis Wee Vanniar Murugapiran,, Nor Azlina Abdul Aziz,, Basripuzi Nurul Hayyan,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2022
Online Access:http://journalarticle.ukm.my/21882/1/MT%2011.pdf
http://journalarticle.ukm.my/21882/
https://jms.mabjournal.com/index.php/mab/index
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spelling my-ukm.journal.218822023-07-12T03:34:02Z http://journalarticle.ukm.my/21882/ Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis Noor Al Majidah Abd Majid, Muhammad Iqbal Ishak, Jagathis Wee Vanniar Murugapiran, Nor Azlina Abdul Aziz, Basripuzi Nurul Hayyan, Parasitic gastroenteritis (PGE) is a significant disease that affects small ruminant production. PGE is controlled exclusively by chemical anthelmintics but restricted by anthelmintic resistance. Hence, dependence on anthelmintics needs to be reduced. This study aimed to investigate the anthelmintic resistance status of a Dorper sheep farm while determining the phenotypic markers of resistance to PGE. Sheep that met the criteria of the Faecal Egg Count Reduction Test (FECRT) were divided into a control and four treatment groups of 11 to 13 animals per group. Faecal and blood samples at pre- and post-treatments were subjected to faecal egg counts (FEC), faecal culture, packed cell volume (PCV) and peripheral eosinophil counts (PEC). The data were analysed by Spearman rank correlation and two-way ANOVA. FECRT showed resistance towards albendazole, levamisole, fenbendazole and ivermectin which was predominated by Haemonchus contortus. Significant negative correlations were observed between FEC and PCV in control (r=-0.88, p<0.01), fenbendazole (r=-0.58, p<0.01) and ivermectin (r=-0.69, p<0.01) groups. Significant positive correlations were detected between FEC and PEC in control (r=0.95, p<0.01) and levamisole (r=0.56, p<0.01) groups. This study shows multiple anthelmintic resistance with promising resistant characteristics against PGE among sheep. Penerbit Universiti Kebangsaan Malaysia 2022 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21882/1/MT%2011.pdf Noor Al Majidah Abd Majid, and Muhammad Iqbal Ishak, and Jagathis Wee Vanniar Murugapiran, and Nor Azlina Abdul Aziz, and Basripuzi Nurul Hayyan, (2022) Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis. Malaysian Applied Biology, 51 (3). pp. 107-115. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/index
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Parasitic gastroenteritis (PGE) is a significant disease that affects small ruminant production. PGE is controlled exclusively by chemical anthelmintics but restricted by anthelmintic resistance. Hence, dependence on anthelmintics needs to be reduced. This study aimed to investigate the anthelmintic resistance status of a Dorper sheep farm while determining the phenotypic markers of resistance to PGE. Sheep that met the criteria of the Faecal Egg Count Reduction Test (FECRT) were divided into a control and four treatment groups of 11 to 13 animals per group. Faecal and blood samples at pre- and post-treatments were subjected to faecal egg counts (FEC), faecal culture, packed cell volume (PCV) and peripheral eosinophil counts (PEC). The data were analysed by Spearman rank correlation and two-way ANOVA. FECRT showed resistance towards albendazole, levamisole, fenbendazole and ivermectin which was predominated by Haemonchus contortus. Significant negative correlations were observed between FEC and PCV in control (r=-0.88, p<0.01), fenbendazole (r=-0.58, p<0.01) and ivermectin (r=-0.69, p<0.01) groups. Significant positive correlations were detected between FEC and PEC in control (r=0.95, p<0.01) and levamisole (r=0.56, p<0.01) groups. This study shows multiple anthelmintic resistance with promising resistant characteristics against PGE among sheep.
format Article
author Noor Al Majidah Abd Majid,
Muhammad Iqbal Ishak,
Jagathis Wee Vanniar Murugapiran,
Nor Azlina Abdul Aziz,
Basripuzi Nurul Hayyan,
spellingShingle Noor Al Majidah Abd Majid,
Muhammad Iqbal Ishak,
Jagathis Wee Vanniar Murugapiran,
Nor Azlina Abdul Aziz,
Basripuzi Nurul Hayyan,
Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis
author_facet Noor Al Majidah Abd Majid,
Muhammad Iqbal Ishak,
Jagathis Wee Vanniar Murugapiran,
Nor Azlina Abdul Aziz,
Basripuzi Nurul Hayyan,
author_sort Noor Al Majidah Abd Majid,
title Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis
title_short Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis
title_full Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis
title_fullStr Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis
title_full_unstemmed Multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis
title_sort multiple anthelmintic resistance among dorper sheep detected with phenotypic markers against parasitic gastroenteritis
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2022
url http://journalarticle.ukm.my/21882/1/MT%2011.pdf
http://journalarticle.ukm.my/21882/
https://jms.mabjournal.com/index.php/mab/index
_version_ 1772812459397087232
score 13.211869

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