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Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram

Coronary heart disease (CHD) is a life-threatening disease caused by obstruction of the coronary arteries that interferes with blood flow known as atherosclerosis. Hyperlipidemia, a risk factor of atherosclerosis, is characterized by excessive concentrations of total cholesterol, LDL, and triglyceri...

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Main Authors: Maulana, Harfi, Ridwan, Ahmad, Suprijanto,, Kusumawardani, Shanty Rahayu, Fitri, Lulu Lusianti
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2023
Online Access:http://journalarticle.ukm.my/21623/1/SD%2020.pdf
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spelling my-ukm.journal.216232023-05-23T03:56:16Z http://journalarticle.ukm.my/21623/ Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram Maulana, Harfi Ridwan, Ahmad Suprijanto, Kusumawardani, Shanty Rahayu Fitri, Lulu Lusianti Coronary heart disease (CHD) is a life-threatening disease caused by obstruction of the coronary arteries that interferes with blood flow known as atherosclerosis. Hyperlipidemia, a risk factor of atherosclerosis, is characterized by excessive concentrations of total cholesterol, LDL, and triglycerides with low concentrations of HDL. A high-fat diet (HFD) contributes to the progression of atherosclerosis, CHD, and other cardiovascular diseases. This study aims to measure electrocardiography (ECG) waves of hyperlipidemia-induced rats. Twenty rats were fed different diets for eight weeks, i.e., the control group (normal diet) and the HFD group (high-fat diet). Their ECG was recorded using a Wireless Mice Electrocardiogram (WIM ECG) for 5-10 min. After eight weeks, the HFD group showed a significantly higher lipid profile concentration (cholesterol: 179.03 mg/dL, triglyceride: 149.11 mg/dL, LDL: 123 mg/dL, HDL: 29.15 mg/dL) than the control. This hyperlipidemic condition causes a significant change in some characteristics of the ECG wave. At week 8, the characteristic ECG wave duration for the HFD groups was RR intervals (176.5 ms), QT intervals (123.5 ms), T waves (33.6 ms), P wave (27.4 ms), QRS interval (64.9 ms), ST-segment (23.7 ms), and heart rate (334 bpm). This study concludes that long-period HFD feeding in rats leads to hyperlipidemia and causes changes in the characteristics of ECG waves. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21623/1/SD%2020.pdf Maulana, Harfi and Ridwan, Ahmad and Suprijanto, and Kusumawardani, Shanty Rahayu and Fitri, Lulu Lusianti (2023) Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram. Sains Malaysiana, 52 (2). pp. 589-597. ISSN 0126-6039 http://www.ukm.my/jsm/index.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Coronary heart disease (CHD) is a life-threatening disease caused by obstruction of the coronary arteries that interferes with blood flow known as atherosclerosis. Hyperlipidemia, a risk factor of atherosclerosis, is characterized by excessive concentrations of total cholesterol, LDL, and triglycerides with low concentrations of HDL. A high-fat diet (HFD) contributes to the progression of atherosclerosis, CHD, and other cardiovascular diseases. This study aims to measure electrocardiography (ECG) waves of hyperlipidemia-induced rats. Twenty rats were fed different diets for eight weeks, i.e., the control group (normal diet) and the HFD group (high-fat diet). Their ECG was recorded using a Wireless Mice Electrocardiogram (WIM ECG) for 5-10 min. After eight weeks, the HFD group showed a significantly higher lipid profile concentration (cholesterol: 179.03 mg/dL, triglyceride: 149.11 mg/dL, LDL: 123 mg/dL, HDL: 29.15 mg/dL) than the control. This hyperlipidemic condition causes a significant change in some characteristics of the ECG wave. At week 8, the characteristic ECG wave duration for the HFD groups was RR intervals (176.5 ms), QT intervals (123.5 ms), T waves (33.6 ms), P wave (27.4 ms), QRS interval (64.9 ms), ST-segment (23.7 ms), and heart rate (334 bpm). This study concludes that long-period HFD feeding in rats leads to hyperlipidemia and causes changes in the characteristics of ECG waves.
format Article
author Maulana, Harfi
Ridwan, Ahmad
Suprijanto,
Kusumawardani, Shanty Rahayu
Fitri, Lulu Lusianti
spellingShingle Maulana, Harfi
Ridwan, Ahmad
Suprijanto,
Kusumawardani, Shanty Rahayu
Fitri, Lulu Lusianti
Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram
author_facet Maulana, Harfi
Ridwan, Ahmad
Suprijanto,
Kusumawardani, Shanty Rahayu
Fitri, Lulu Lusianti
author_sort Maulana, Harfi
title Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram
title_short Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram
title_full Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram
title_fullStr Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram
title_full_unstemmed Electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram
title_sort electrocardiogram analysis of hyperlipidemia-induced wistar rats using wireless mice electrocardiogram
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2023
url http://journalarticle.ukm.my/21623/1/SD%2020.pdf
http://journalarticle.ukm.my/21623/
http://www.ukm.my/jsm/index.html
_version_ 1768008350493048832
score 13.211869

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