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A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves

Christia vespertilionis is a plant traditionally used to treat various diseases, including inflammation. This study aims to compare and analyze the anti-inflammatory properties and activities of green and red C. vespertilionis leaves and to determine the correlation between the protease inhibition...

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Main Authors: Izzah Farhah Zambari,, Nur Airina Muhamad,, Sitti Rahma Abdul Hafid,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2023
Online Access:http://journalarticle.ukm.my/21546/1/S%2017.pdf
http://journalarticle.ukm.my/21546/
http://www.ukm.my/jsm/index.html
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spelling my-ukm.journal.215462023-05-09T03:52:30Z http://journalarticle.ukm.my/21546/ A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves Izzah Farhah Zambari, Nur Airina Muhamad, Sitti Rahma Abdul Hafid, Christia vespertilionis is a plant traditionally used to treat various diseases, including inflammation. This study aims to compare and analyze the anti-inflammatory properties and activities of green and red C. vespertilionis leaves and to determine the correlation between the protease inhibition assay and phenolic content. Preliminary phytochemical analysis showed the presence of alkaloids, tannins, saponins, cardenolides, phenolics, cardiac glycosides, flavonoids, and steroids in green and red leaves. Green leaf had the highest anti-inflammation potential, with a high extraction yield (6.39 ± 0.01%), phenolic content (29.25 ± 0.50 mg) gallic acid equivalent [GAE]/mL), flavonoid content (1.57 ± 0.03 mg quercetin acid equivalent [QE]/mL) and tannin content (22.70 ± 3.15 mg tannic acid equivalent [TAE]/mL). Green leaf contained more anti-inflammatory compounds, including n-hexadecanoic acid, phytol, 9, 12, 15-octadecatrienoic acid (Z, Z, Z)- and squalene. The protease inhibition assay showed that green leaf had anti-inflammatory activity at 66.55 ± 2.59% with the half-maximal inhibitory concentration (IC50) of 284.59 ± 10.63 μg/mL. The green leaf showed a significant positive correlation between the protease inhibition assay and phenolic content, with R2 = 0.6821. We conclude that both green and red C. vespertilionis types have the potential to act as anti-inflammatory agents, but green leaves are preferable. Penerbit Universiti Kebangsaan Malaysia 2023 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21546/1/S%2017.pdf Izzah Farhah Zambari, and Nur Airina Muhamad, and Sitti Rahma Abdul Hafid, (2023) A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves. Sains Malaysiana, 52 (1). pp. 211-222. ISSN 0126-6039 http://www.ukm.my/jsm/index.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Christia vespertilionis is a plant traditionally used to treat various diseases, including inflammation. This study aims to compare and analyze the anti-inflammatory properties and activities of green and red C. vespertilionis leaves and to determine the correlation between the protease inhibition assay and phenolic content. Preliminary phytochemical analysis showed the presence of alkaloids, tannins, saponins, cardenolides, phenolics, cardiac glycosides, flavonoids, and steroids in green and red leaves. Green leaf had the highest anti-inflammation potential, with a high extraction yield (6.39 ± 0.01%), phenolic content (29.25 ± 0.50 mg) gallic acid equivalent [GAE]/mL), flavonoid content (1.57 ± 0.03 mg quercetin acid equivalent [QE]/mL) and tannin content (22.70 ± 3.15 mg tannic acid equivalent [TAE]/mL). Green leaf contained more anti-inflammatory compounds, including n-hexadecanoic acid, phytol, 9, 12, 15-octadecatrienoic acid (Z, Z, Z)- and squalene. The protease inhibition assay showed that green leaf had anti-inflammatory activity at 66.55 ± 2.59% with the half-maximal inhibitory concentration (IC50) of 284.59 ± 10.63 μg/mL. The green leaf showed a significant positive correlation between the protease inhibition assay and phenolic content, with R2 = 0.6821. We conclude that both green and red C. vespertilionis types have the potential to act as anti-inflammatory agents, but green leaves are preferable.
format Article
author Izzah Farhah Zambari,
Nur Airina Muhamad,
Sitti Rahma Abdul Hafid,
spellingShingle Izzah Farhah Zambari,
Nur Airina Muhamad,
Sitti Rahma Abdul Hafid,
A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves
author_facet Izzah Farhah Zambari,
Nur Airina Muhamad,
Sitti Rahma Abdul Hafid,
author_sort Izzah Farhah Zambari,
title A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves
title_short A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves
title_full A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves
title_fullStr A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves
title_full_unstemmed A comparative study of anti-inflammatory properties and activities of green and red Christia vespertilionis leaves
title_sort comparative study of anti-inflammatory properties and activities of green and red christia vespertilionis leaves
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2023
url http://journalarticle.ukm.my/21546/1/S%2017.pdf
http://journalarticle.ukm.my/21546/
http://www.ukm.my/jsm/index.html
_version_ 1768008340341784576
score 13.211869

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