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Emergence of dengue virus type 4 during COVID-19 pandemic in patients admitted to a teaching hospital in Malaysia

Prior to COVID-19, dengue was an important public health problem in Malaysia. Due to the movement control order imposed by the Malaysian government to curb the COVID-19 transmission, a study predicted that mosquito-borne diseases would increase during lockdown and partial lockdown seasons. Thus, thi...

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Main Authors: Mahrunissa Mahadi,, Siti Norlia Othman,, Najma Kori,, Sharifah Azura Salleh,, Zetti Zainol Rashid,, Petrick Periyasamy,, Nor Azila Muhammad Azami,, Noraidatulakma Abdullah,, Hui-min Neoh,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2023
Online Access:http://journalarticle.ukm.my/21367/1/55912-201721-2-PB.pdf
http://journalarticle.ukm.my/21367/
https://ejournals.ukm.my/jskm/issue/view/1525
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spelling my-ukm.journal.213672023-03-16T08:00:27Z http://journalarticle.ukm.my/21367/ Emergence of dengue virus type 4 during COVID-19 pandemic in patients admitted to a teaching hospital in Malaysia Mahrunissa Mahadi, Siti Norlia Othman, Najma Kori, Sharifah Azura Salleh, Zetti Zainol Rashid, Petrick Periyasamy, Nor Azila Muhammad Azami, Noraidatulakma Abdullah, Hui-min Neoh, Prior to COVID-19, dengue was an important public health problem in Malaysia. Due to the movement control order imposed by the Malaysian government to curb the COVID-19 transmission, a study predicted that mosquito-borne diseases would increase during lockdown and partial lockdown seasons. Thus, this study aims to determine the current situation of dengue incidence during the pre-COVID-19 pandemic (2019) and during the COVID-19 pandemic (2020 and 2021). We compared the number of laboratory-confirmed cases in the pre-COVID19 year (2019) and during the COVID-19 pandemic (2020 and 2021). In addition to that, we characterized the clinical manifestation, dengue serotype and viremia levels of dengue patients that were admitted to the Hospital Cancelor Tuanku Muhriz. We found a significant decrease in the number of laboratory-confirmed cases between COVID-19 pandemic and the pre-covid period (p2020=0.064; p2021<0.001). In this study, we found DENV 4 serotype was the most common serotype in dengue patients admitted to our hospital. There was no significant correlation between DENV serotype/viremia level with clinical manifestation of dengue fever and dengue with warning signs. However, patients infected with DENV4 had the highest viral load compared to patients infected with other serotypes. We also found high viremia levels were significantly associated with the febrile phase. Penerbit Universiti Kebangsaan Malaysia 2023-01 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21367/1/55912-201721-2-PB.pdf Mahrunissa Mahadi, and Siti Norlia Othman, and Najma Kori, and Sharifah Azura Salleh, and Zetti Zainol Rashid, and Petrick Periyasamy, and Nor Azila Muhammad Azami, and Noraidatulakma Abdullah, and Hui-min Neoh, (2023) Emergence of dengue virus type 4 during COVID-19 pandemic in patients admitted to a teaching hospital in Malaysia. Jurnal Sains Kesihatan Malaysia, 21 (1). pp. 115-125. ISSN 1675-8161 https://ejournals.ukm.my/jskm/issue/view/1525
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Prior to COVID-19, dengue was an important public health problem in Malaysia. Due to the movement control order imposed by the Malaysian government to curb the COVID-19 transmission, a study predicted that mosquito-borne diseases would increase during lockdown and partial lockdown seasons. Thus, this study aims to determine the current situation of dengue incidence during the pre-COVID-19 pandemic (2019) and during the COVID-19 pandemic (2020 and 2021). We compared the number of laboratory-confirmed cases in the pre-COVID19 year (2019) and during the COVID-19 pandemic (2020 and 2021). In addition to that, we characterized the clinical manifestation, dengue serotype and viremia levels of dengue patients that were admitted to the Hospital Cancelor Tuanku Muhriz. We found a significant decrease in the number of laboratory-confirmed cases between COVID-19 pandemic and the pre-covid period (p2020=0.064; p2021<0.001). In this study, we found DENV 4 serotype was the most common serotype in dengue patients admitted to our hospital. There was no significant correlation between DENV serotype/viremia level with clinical manifestation of dengue fever and dengue with warning signs. However, patients infected with DENV4 had the highest viral load compared to patients infected with other serotypes. We also found high viremia levels were significantly associated with the febrile phase.
format Article
author Mahrunissa Mahadi,
Siti Norlia Othman,
Najma Kori,
Sharifah Azura Salleh,
Zetti Zainol Rashid,
Petrick Periyasamy,
Nor Azila Muhammad Azami,
Noraidatulakma Abdullah,
Hui-min Neoh,
spellingShingle Mahrunissa Mahadi,
Siti Norlia Othman,
Najma Kori,
Sharifah Azura Salleh,
Zetti Zainol Rashid,
Petrick Periyasamy,
Nor Azila Muhammad Azami,
Noraidatulakma Abdullah,
Hui-min Neoh,
Emergence of dengue virus type 4 during COVID-19 pandemic in patients admitted to a teaching hospital in Malaysia
author_facet Mahrunissa Mahadi,
Siti Norlia Othman,
Najma Kori,
Sharifah Azura Salleh,
Zetti Zainol Rashid,
Petrick Periyasamy,
Nor Azila Muhammad Azami,
Noraidatulakma Abdullah,
Hui-min Neoh,
author_sort Mahrunissa Mahadi,
title Emergence of dengue virus type 4 during COVID-19 pandemic in patients admitted to a teaching hospital in Malaysia
title_short Emergence of dengue virus type 4 during COVID-19 pandemic in patients admitted to a teaching hospital in Malaysia
title_full Emergence of dengue virus type 4 during COVID-19 pandemic in patients admitted to a teaching hospital in Malaysia
title_fullStr Emergence of dengue virus type 4 during COVID-19 pandemic in patients admitted to a teaching hospital in Malaysia
title_full_unstemmed Emergence of dengue virus type 4 during COVID-19 pandemic in patients admitted to a teaching hospital in Malaysia
title_sort emergence of dengue virus type 4 during covid-19 pandemic in patients admitted to a teaching hospital in malaysia
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2023
url http://journalarticle.ukm.my/21367/1/55912-201721-2-PB.pdf
http://journalarticle.ukm.my/21367/
https://ejournals.ukm.my/jskm/issue/view/1525
_version_ 1761617594080559104
score 13.211869

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