Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML)
The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia (AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype. Several studies showed that patients carrying this abnormality demonstrated good response to standard chemotherapy but also have a...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit UKM
2010
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| Online Access: | http://journalarticle.ukm.my/2079/1/08MS090_4144.pdf http://journalarticle.ukm.my/2079/ http://www.ppukm.ukm.my/ukmmcjournal/index.php |
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| Summary: | The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia
(AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype.
Several studies showed that patients carrying this abnormality demonstrated good
response to standard chemotherapy but also have a high incidence of disease relapse.
Trisomy 4 is a rare and specific chromosomal abnormality occurring in AML M2 or M4
of the FAB subtypes. We report a case of a 33-year-old female with an apparently
clinical and hematologic diagnosis of acute promyelocytic leukemia (APL) in whom
cytogenetic analysis revealed an abnormal karyotype with trisomy 4, in addition to
t(8;21). Trisomy 4 and t(8;21) in a patient with AML is rare. The significance of t(8;21)
with trisomy 4 in AML are unclear but patients bearing this abnormality are associated
with a poor prognosis. |
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