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The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary

Mature cystic teratoma is the commonest ovarian germ cell tumour which accounts for 70% of all benign ovarian neoplasms in the reproductive age groups. Being a pluripotent germ cell tumour, mature cystic teratoma has at least two out of three mature embryonic germ cell components: ectoderm, meso...

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Main Authors: Wong, Yin Ping, Tan, GC
Format: Article
Language:English
Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/20626/1/25_ms0245_pdf_19410.pdf
http://journalarticle.ukm.my/20626/
https://www.medicineandhealthukm.com/toc/13/2
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spelling my-ukm.journal.206262022-11-28T13:16:15Z http://journalarticle.ukm.my/20626/ The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary Wong, Yin Ping Tan, GC Mature cystic teratoma is the commonest ovarian germ cell tumour which accounts for 70% of all benign ovarian neoplasms in the reproductive age groups. Being a pluripotent germ cell tumour, mature cystic teratoma has at least two out of three mature embryonic germ cell components: ectoderm, mesoderm and endoderm. The presence of multiple cystic spaces within the tumour wall, also known as pneumatosis cystoides-like appearance is rarely described but a characteristic feature in cystic teratoma of the ovary. Currently, there is little information concerning the mechanism of its formation. Herein, we described an unusual case of ovarian mature cystic teratoma in a 31-year-old pregnant female with multiple sieve-like areas resembling pneumatosis cystoides of the intestine. Macroscopic and histological examination of the ovary revealed features diagnostic of mature cystic teratoma. Intriguingly, multiple cystic spaces of variable sizes were found within the cyst wall histologically. They were lined partially or completely by foamy histiocytes and foreign body type multinucleated giant cells, exhibiting strong CD68 immunoreactivity. Vascular endothelial markers (CD31 and CD34) and epithelial marker (cytokeratin AE1/AE3) were negative. A diagnosis of mature cystic teratoma with pneumatosis cystoides-like feature was rendered. The patient was discharged well with no signs and symptoms of early labour. The etiopathogenesis of this intriguing histological feature is briefly discussed in this article. Pusat Perubatan Universiti Kebangsaan Malaysia 2018-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/20626/1/25_ms0245_pdf_19410.pdf Wong, Yin Ping and Tan, GC (2018) The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary. Medicine & Health, 13 (2). pp. 223-228. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/13/2
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Mature cystic teratoma is the commonest ovarian germ cell tumour which accounts for 70% of all benign ovarian neoplasms in the reproductive age groups. Being a pluripotent germ cell tumour, mature cystic teratoma has at least two out of three mature embryonic germ cell components: ectoderm, mesoderm and endoderm. The presence of multiple cystic spaces within the tumour wall, also known as pneumatosis cystoides-like appearance is rarely described but a characteristic feature in cystic teratoma of the ovary. Currently, there is little information concerning the mechanism of its formation. Herein, we described an unusual case of ovarian mature cystic teratoma in a 31-year-old pregnant female with multiple sieve-like areas resembling pneumatosis cystoides of the intestine. Macroscopic and histological examination of the ovary revealed features diagnostic of mature cystic teratoma. Intriguingly, multiple cystic spaces of variable sizes were found within the cyst wall histologically. They were lined partially or completely by foamy histiocytes and foreign body type multinucleated giant cells, exhibiting strong CD68 immunoreactivity. Vascular endothelial markers (CD31 and CD34) and epithelial marker (cytokeratin AE1/AE3) were negative. A diagnosis of mature cystic teratoma with pneumatosis cystoides-like feature was rendered. The patient was discharged well with no signs and symptoms of early labour. The etiopathogenesis of this intriguing histological feature is briefly discussed in this article.
format Article
author Wong, Yin Ping
Tan, GC
spellingShingle Wong, Yin Ping
Tan, GC
The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary
author_facet Wong, Yin Ping
Tan, GC
author_sort Wong, Yin Ping
title The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary
title_short The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary
title_full The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary
title_fullStr The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary
title_full_unstemmed The eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary
title_sort eyes do not see what the mind does not know : an underreported feature in mature cystic teratoma of the ovary
publisher Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate 2018
url http://journalarticle.ukm.my/20626/1/25_ms0245_pdf_19410.pdf
http://journalarticle.ukm.my/20626/
https://www.medicineandhealthukm.com/toc/13/2
_version_ 1751537487188066304
score 13.211869

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