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Four years analysis of helicobacter pylori infection among patients with dyspeptic at Universiti Kebangsaan Malaysia Medical Centre

Helicobacter pylori has been implicated as an aetiologic agent for type B chronic gastritis, peptic ulcer and gastric cancer. It is considered the most common bacterial infection in the world with approximately 50% of the population being infected. The majority of infected individuals are asympto...

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Main Authors: Alfizah H,, Rizal AM,, Isa MR,, Aminudin A,, Jasmi AY,, Ramelah M,
Format: Article
Language:English
Published: Penerbit UKM 2010
Online Access:http://journalarticle.ukm.my/2045/1/04MS102_112.pdf
http://journalarticle.ukm.my/2045/
http://www.ppukm.ukm.my/ukmmcjournal/index.php
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spelling my-ukm.journal.20452016-12-14T06:30:45Z http://journalarticle.ukm.my/2045/ Four years analysis of helicobacter pylori infection among patients with dyspeptic at Universiti Kebangsaan Malaysia Medical Centre Alfizah H, Rizal AM, Isa MR, Aminudin A, Jasmi AY, Ramelah M, Helicobacter pylori has been implicated as an aetiologic agent for type B chronic gastritis, peptic ulcer and gastric cancer. It is considered the most common bacterial infection in the world with approximately 50% of the population being infected. The majority of infected individuals are asymptomatic, with some developing gastritis only. However, chronic infection with H. pylori without antibiotic treatment predisposes infected individuals to the development of gastric cancer. The aim of this study is to determine active H. pylori infection among patients with symptoms of dyspepsia using three combinations of diagnostic methods. In this report, we studied 1,376 consecutive patients who underwent upper gastrointestinal endoscopy at Universiti Kebangsaan Malaysia Medical Center (UKMMC) for dyspepsia from the period January 1999 to December 2002. The classification of patient’s diagnosis was assessed by endoscopic and histological examination. The H. pylori status was determined by rapid urease test, histological examination or H. pylori culture. Presence of H. pylori infection was confirmed in 30.8% of patients with dyspepsia. H. pylori infection was more prevalent in older patients and in males compared to females. Patients with severe gastroduodenal diseases were more commonly infected with H. pylori. There was a significant difference in H. pylori prevalence among the different ethnic groups. Indians had the highest infection rate (45.4%), followed by Chinese (36.8%) and the lowest were seen in Malays (18.3%). This finding on determination of active H. pylori infection among patients with dyspepsia is consistent with serological studies that showed racial differences in H. pylori prevalence. However, the pattern of H. pylori infection does not reflect the prevalence of severe gastroduodenal diseases among different ethnic groups. Penerbit UKM 2010 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2045/1/04MS102_112.pdf Alfizah H, and Rizal AM, and Isa MR, and Aminudin A, and Jasmi AY, and Ramelah M, (2010) Four years analysis of helicobacter pylori infection among patients with dyspeptic at Universiti Kebangsaan Malaysia Medical Centre. Medicine & Health, 5 (1). pp. 13-21. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Helicobacter pylori has been implicated as an aetiologic agent for type B chronic gastritis, peptic ulcer and gastric cancer. It is considered the most common bacterial infection in the world with approximately 50% of the population being infected. The majority of infected individuals are asymptomatic, with some developing gastritis only. However, chronic infection with H. pylori without antibiotic treatment predisposes infected individuals to the development of gastric cancer. The aim of this study is to determine active H. pylori infection among patients with symptoms of dyspepsia using three combinations of diagnostic methods. In this report, we studied 1,376 consecutive patients who underwent upper gastrointestinal endoscopy at Universiti Kebangsaan Malaysia Medical Center (UKMMC) for dyspepsia from the period January 1999 to December 2002. The classification of patient’s diagnosis was assessed by endoscopic and histological examination. The H. pylori status was determined by rapid urease test, histological examination or H. pylori culture. Presence of H. pylori infection was confirmed in 30.8% of patients with dyspepsia. H. pylori infection was more prevalent in older patients and in males compared to females. Patients with severe gastroduodenal diseases were more commonly infected with H. pylori. There was a significant difference in H. pylori prevalence among the different ethnic groups. Indians had the highest infection rate (45.4%), followed by Chinese (36.8%) and the lowest were seen in Malays (18.3%). This finding on determination of active H. pylori infection among patients with dyspepsia is consistent with serological studies that showed racial differences in H. pylori prevalence. However, the pattern of H. pylori infection does not reflect the prevalence of severe gastroduodenal diseases among different ethnic groups.
format Article
author Alfizah H,
Rizal AM,
Isa MR,
Aminudin A,
Jasmi AY,
Ramelah M,
spellingShingle Alfizah H,
Rizal AM,
Isa MR,
Aminudin A,
Jasmi AY,
Ramelah M,
Four years analysis of helicobacter pylori infection among patients with dyspeptic at Universiti Kebangsaan Malaysia Medical Centre
author_facet Alfizah H,
Rizal AM,
Isa MR,
Aminudin A,
Jasmi AY,
Ramelah M,
author_sort Alfizah H,
title Four years analysis of helicobacter pylori infection among patients with dyspeptic at Universiti Kebangsaan Malaysia Medical Centre
title_short Four years analysis of helicobacter pylori infection among patients with dyspeptic at Universiti Kebangsaan Malaysia Medical Centre
title_full Four years analysis of helicobacter pylori infection among patients with dyspeptic at Universiti Kebangsaan Malaysia Medical Centre
title_fullStr Four years analysis of helicobacter pylori infection among patients with dyspeptic at Universiti Kebangsaan Malaysia Medical Centre
title_full_unstemmed Four years analysis of helicobacter pylori infection among patients with dyspeptic at Universiti Kebangsaan Malaysia Medical Centre
title_sort four years analysis of helicobacter pylori infection among patients with dyspeptic at universiti kebangsaan malaysia medical centre
publisher Penerbit UKM
publishDate 2010
url http://journalarticle.ukm.my/2045/1/04MS102_112.pdf
http://journalarticle.ukm.my/2045/
http://www.ppukm.ukm.my/ukmmcjournal/index.php
_version_ 1643735243614584832
score 13.211869

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