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Exploring alternative medicines in the treatment of atherosclerosis : an insight into molecular aspect

Malaysia is blessed to have several natural products. Since past decades, studies have been carried out to discover the highly effective anti-atherosclerotic supplements. The phytoestrogens and soy proteins have gained much attention, over the years. Several literature highlighted the therapeutic...

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Main Authors: Lina Izzati A,, Haszianaliza H,, Zar, Chi Thent
Format: Article
Language:English
Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2018
Online Access:http://journalarticle.ukm.my/20199/1/6_ms0226_pdf_14147.pdf
http://journalarticle.ukm.my/20199/
https://www.medicineandhealthukm.com/toc/13/1
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spelling my-ukm.journal.201992022-10-21T08:16:02Z http://journalarticle.ukm.my/20199/ Exploring alternative medicines in the treatment of atherosclerosis : an insight into molecular aspect Lina Izzati A, Haszianaliza H, Zar, Chi Thent Malaysia is blessed to have several natural products. Since past decades, studies have been carried out to discover the highly effective anti-atherosclerotic supplements. The phytoestrogens and soy proteins have gained much attention, over the years. Several literature highlighted the therapeutic effect of alternative medicines on atherosclerosis. However, the overall anti-atherosclerotic mechanism of isoflavones regardless of menopause or postmenopausal state was not discussed, to date. This review aimed to summarize the molecular mechanism of different types of alternative medicines for the treatment of atherosclerosis in general population. The herbs commonly used in the treatment of atherosclerosis are garlic (Allium sativum), pomegranate (Punica granatum), ginger (Zingiber officinale), cinnamon (Cinnamomum spp.) and green tea (Camellia sinenses). Nevertheless, the palm oil, coconut oil, olive oil and omega-3 also plays significant role in attenuating the risk of atherosclerosis by decreasing the LDL level, increasing the endothelial nitric oxide synthase (eNOS), scavenging the free radicals and also decreasing the inflammatory process. Daidzein improves atherosclerotic changes by activating the NF-ĸB pathway and regulating the expression of inflammatory cytokines. Genistein reduces the monocyte-endothelial cell and adhesion molecules secretion via cAMP/PKA pathway, it decreases the inflammatory response via initiation of nuclear factor erythroid 2-related factor (Nrf2)/ heme oxygenase-1 (HO-1) pathway. Conclusively, we recognized that alternative medicines demonstrate remarkable therapeutic efficacy for the treatment of atherosclerosis in patients of all ages. Pusat Perubatan Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/20199/1/6_ms0226_pdf_14147.pdf Lina Izzati A, and Haszianaliza H, and Zar, Chi Thent (2018) Exploring alternative medicines in the treatment of atherosclerosis : an insight into molecular aspect. Medicine & Health, 13 (1). pp. 49-70. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/13/1
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Malaysia is blessed to have several natural products. Since past decades, studies have been carried out to discover the highly effective anti-atherosclerotic supplements. The phytoestrogens and soy proteins have gained much attention, over the years. Several literature highlighted the therapeutic effect of alternative medicines on atherosclerosis. However, the overall anti-atherosclerotic mechanism of isoflavones regardless of menopause or postmenopausal state was not discussed, to date. This review aimed to summarize the molecular mechanism of different types of alternative medicines for the treatment of atherosclerosis in general population. The herbs commonly used in the treatment of atherosclerosis are garlic (Allium sativum), pomegranate (Punica granatum), ginger (Zingiber officinale), cinnamon (Cinnamomum spp.) and green tea (Camellia sinenses). Nevertheless, the palm oil, coconut oil, olive oil and omega-3 also plays significant role in attenuating the risk of atherosclerosis by decreasing the LDL level, increasing the endothelial nitric oxide synthase (eNOS), scavenging the free radicals and also decreasing the inflammatory process. Daidzein improves atherosclerotic changes by activating the NF-ĸB pathway and regulating the expression of inflammatory cytokines. Genistein reduces the monocyte-endothelial cell and adhesion molecules secretion via cAMP/PKA pathway, it decreases the inflammatory response via initiation of nuclear factor erythroid 2-related factor (Nrf2)/ heme oxygenase-1 (HO-1) pathway. Conclusively, we recognized that alternative medicines demonstrate remarkable therapeutic efficacy for the treatment of atherosclerosis in patients of all ages.
format Article
author Lina Izzati A,
Haszianaliza H,
Zar, Chi Thent
spellingShingle Lina Izzati A,
Haszianaliza H,
Zar, Chi Thent
Exploring alternative medicines in the treatment of atherosclerosis : an insight into molecular aspect
author_facet Lina Izzati A,
Haszianaliza H,
Zar, Chi Thent
author_sort Lina Izzati A,
title Exploring alternative medicines in the treatment of atherosclerosis : an insight into molecular aspect
title_short Exploring alternative medicines in the treatment of atherosclerosis : an insight into molecular aspect
title_full Exploring alternative medicines in the treatment of atherosclerosis : an insight into molecular aspect
title_fullStr Exploring alternative medicines in the treatment of atherosclerosis : an insight into molecular aspect
title_full_unstemmed Exploring alternative medicines in the treatment of atherosclerosis : an insight into molecular aspect
title_sort exploring alternative medicines in the treatment of atherosclerosis : an insight into molecular aspect
publisher Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate 2018
url http://journalarticle.ukm.my/20199/1/6_ms0226_pdf_14147.pdf
http://journalarticle.ukm.my/20199/
https://www.medicineandhealthukm.com/toc/13/1
_version_ 1748181780485111808
score 13.211869

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