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(+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors

The phytochemical study on the dichloromethane extract of Neolamarckia cadamba (Roxb.) Bosser has afforded two indole alkaloids, (+)-neocadambine A (1) and (-)-nauclederine (2). Their structures were confirmed by extensive spectroscopic analysis and by comparing with the reported data. (+)-Neocadamb...

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Main Authors: Noor Aimi Othman,, Liew, Sook Yee, Blanchard, Patricia, Derbré, Séverine, Chong, Soon-Lim, Abdul Manaf Ali,, Khalijah Awang,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2022
Online Access:http://journalarticle.ukm.my/19747/1/10.pdf
http://journalarticle.ukm.my/19747/
https://www.ukm.my/jsm/malay_journals/jilid51bil6_2022/KandunganJilid51Bil6_2022.html
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spelling my-ukm.journal.197472022-09-19T06:48:16Z http://journalarticle.ukm.my/19747/ (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors Noor Aimi Othman, Liew, Sook Yee Blanchard, Patricia Derbré, Séverine Chong, Soon-Lim Abdul Manaf Ali, Khalijah Awang, The phytochemical study on the dichloromethane extract of Neolamarckia cadamba (Roxb.) Bosser has afforded two indole alkaloids, (+)-neocadambine A (1) and (-)-nauclederine (2). Their structures were confirmed by extensive spectroscopic analysis and by comparing with the reported data. (+)-Neocadambine A (1) and (-)-nauclederine (2) exhibited potent inhibition activity of advanced glycation end products (AGEs) with IC50 values of 1.2 and 0.95 mM, respectively, while the latter was almost two times more potent than the standard, aminoguanidine (1.8 mM). This is the first report on the compounds isolated from this plant with AGEs inhibition activity. In addition, (-)-nauclederine (2) was isolated for the first time in the genus of Neolamarckia. Complete 1H-NMR and 13C-NMR of compound 2 were also reported. Penerbit Universiti Kebangsaan Malaysia 2022-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/19747/1/10.pdf Noor Aimi Othman, and Liew, Sook Yee and Blanchard, Patricia and Derbré, Séverine and Chong, Soon-Lim and Abdul Manaf Ali, and Khalijah Awang, (2022) (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors. Sains Malaysiana, 51 (6). pp. 1725-1732. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid51bil6_2022/KandunganJilid51Bil6_2022.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The phytochemical study on the dichloromethane extract of Neolamarckia cadamba (Roxb.) Bosser has afforded two indole alkaloids, (+)-neocadambine A (1) and (-)-nauclederine (2). Their structures were confirmed by extensive spectroscopic analysis and by comparing with the reported data. (+)-Neocadambine A (1) and (-)-nauclederine (2) exhibited potent inhibition activity of advanced glycation end products (AGEs) with IC50 values of 1.2 and 0.95 mM, respectively, while the latter was almost two times more potent than the standard, aminoguanidine (1.8 mM). This is the first report on the compounds isolated from this plant with AGEs inhibition activity. In addition, (-)-nauclederine (2) was isolated for the first time in the genus of Neolamarckia. Complete 1H-NMR and 13C-NMR of compound 2 were also reported.
format Article
author Noor Aimi Othman,
Liew, Sook Yee
Blanchard, Patricia
Derbré, Séverine
Chong, Soon-Lim
Abdul Manaf Ali,
Khalijah Awang,
spellingShingle Noor Aimi Othman,
Liew, Sook Yee
Blanchard, Patricia
Derbré, Séverine
Chong, Soon-Lim
Abdul Manaf Ali,
Khalijah Awang,
(+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors
author_facet Noor Aimi Othman,
Liew, Sook Yee
Blanchard, Patricia
Derbré, Séverine
Chong, Soon-Lim
Abdul Manaf Ali,
Khalijah Awang,
author_sort Noor Aimi Othman,
title (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors
title_short (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors
title_full (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors
title_fullStr (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors
title_full_unstemmed (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors
title_sort (+)-neocadambine a and (-)-nauclederine isolated from the bark of neolamarckia cadamba (rubiaceae) as natural advanced glycation end products (ages) inhibitors
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2022
url http://journalarticle.ukm.my/19747/1/10.pdf
http://journalarticle.ukm.my/19747/
https://www.ukm.my/jsm/malay_journals/jilid51bil6_2022/KandunganJilid51Bil6_2022.html
_version_ 1744649874761056256
score 13.211869

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