Cover Image

Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients

Protein A-immunoadsorption (IA) is an extracorporeal apheresis technique used in patients with autoimmune diseases which aims to remove pathogenic autoantibodies. Apart from the adsorption of immunoglobulins (IgG), IA may influence cellular and humoral immunity. The aim of this study was to observe...

Full description

Saved in:
Bibliographic Details
Main Authors: Li, Xiejia, Li, Zheng, Deng, Hongmei, Sun, Cuifang, Liu, Hong, Yuan, Fang
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2022
Online Access:http://journalarticle.ukm.my/19279/1/17.pdf
http://journalarticle.ukm.my/19279/
https://www.ukm.my/jsm/malay_journals/jilid51bil4_2022/KandunganJilid51Bil4_2022.html
Tags: Add Tag
No Tags, Be the first to tag this record!
id my-ukm.journal.19279
record_format eprints
spelling my-ukm.journal.192792022-08-08T06:41:24Z http://journalarticle.ukm.my/19279/ Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients Li, Xiejia Li, Zheng Deng, Hongmei Sun, Cuifang Liu, Hong Yuan, Fang Protein A-immunoadsorption (IA) is an extracorporeal apheresis technique used in patients with autoimmune diseases which aims to remove pathogenic autoantibodies. Apart from the adsorption of immunoglobulins (IgG), IA may influence cellular and humoral immunity. The aim of this study was to observe the effect of protein A-IA on cytokine networks in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients. A total of 12 newly diagnosed AAV patients received IA therapy on days 1, 3, and 5. Serum levels of inflammatory cytokines were measured before and after treatment including members of the interleukin family, PDGF-BB, TNF-α and IFN-γ. IL-1β, IL-9, IL-17A, PDGF-BB, IFN-γ, and TNF-α were elevated in AAV patients compared to healthy individuals. There were no changes in the levels of any cytokines after the first IA session but after 3 sessions, IL-9, PDGF-BB, and TNF-α dramatically decreased. Moreover, reductions in IL-9 levels were positively correlated with the changes of myeloperoxidase-ANCA (MPO-ANCA). Our observations suggest that protein A-IA therapy does not directly adsorb cytokines, but removes autoantibodies (MPO-ANCA) which indirectly leads to changes in cytokine networks linked to cellular or humoral immunity. Penerbit Universiti Kebangsaan Malaysia 2022-04 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/19279/1/17.pdf Li, Xiejia and Li, Zheng and Deng, Hongmei and Sun, Cuifang and Liu, Hong and Yuan, Fang (2022) Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients. Sains Malaysiana, 51 (4). pp. 1155-1165. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid51bil4_2022/KandunganJilid51Bil4_2022.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Protein A-immunoadsorption (IA) is an extracorporeal apheresis technique used in patients with autoimmune diseases which aims to remove pathogenic autoantibodies. Apart from the adsorption of immunoglobulins (IgG), IA may influence cellular and humoral immunity. The aim of this study was to observe the effect of protein A-IA on cytokine networks in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients. A total of 12 newly diagnosed AAV patients received IA therapy on days 1, 3, and 5. Serum levels of inflammatory cytokines were measured before and after treatment including members of the interleukin family, PDGF-BB, TNF-α and IFN-γ. IL-1β, IL-9, IL-17A, PDGF-BB, IFN-γ, and TNF-α were elevated in AAV patients compared to healthy individuals. There were no changes in the levels of any cytokines after the first IA session but after 3 sessions, IL-9, PDGF-BB, and TNF-α dramatically decreased. Moreover, reductions in IL-9 levels were positively correlated with the changes of myeloperoxidase-ANCA (MPO-ANCA). Our observations suggest that protein A-IA therapy does not directly adsorb cytokines, but removes autoantibodies (MPO-ANCA) which indirectly leads to changes in cytokine networks linked to cellular or humoral immunity.
format Article
author Li, Xiejia
Li, Zheng
Deng, Hongmei
Sun, Cuifang
Liu, Hong
Yuan, Fang
spellingShingle Li, Xiejia
Li, Zheng
Deng, Hongmei
Sun, Cuifang
Liu, Hong
Yuan, Fang
Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients
author_facet Li, Xiejia
Li, Zheng
Deng, Hongmei
Sun, Cuifang
Liu, Hong
Yuan, Fang
author_sort Li, Xiejia
title Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients
title_short Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients
title_full Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients
title_fullStr Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients
title_full_unstemmed Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients
title_sort effect of protein a-immunoadsorption therapy on serum cytokines in aav patients
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2022
url http://journalarticle.ukm.my/19279/1/17.pdf
http://journalarticle.ukm.my/19279/
https://www.ukm.my/jsm/malay_journals/jilid51bil4_2022/KandunganJilid51Bil4_2022.html
_version_ 1740826835143360512
score 13.211869

Similar Items