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Oral administration of Garcinia dulcis flower extract lowers arterial blood pressure of 2-kidneys-1-clip renovascular hypertensive rat

The hexane insoluble fraction of the Garcinia dulcis (GD) flower extract comprises mainly camboginol and morelloflavone which possess potent in vivo and in vitro antioxidant properties. This study aimed to evaluate the effects of 4-week oral administration of GD flower extract on the arterial blood...

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Main Authors: Nattaya Thongsepee,, Wilawan Mahabusarakam,, Sophapun Ekarattanawong,, Umarat Srisawat,, Pongsakorn Martviset,, Noppadon Suttirak,, Siriphun Hiranyachattada,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2022
Online Access:http://journalarticle.ukm.my/19169/1/18.pdf
http://journalarticle.ukm.my/19169/
https://www.ukm.my/jsm/malay_journals/jilid51bil3_2022/KandunganJilid51Bil3_2022.html
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spelling my-ukm.journal.191692022-08-01T04:22:48Z http://journalarticle.ukm.my/19169/ Oral administration of Garcinia dulcis flower extract lowers arterial blood pressure of 2-kidneys-1-clip renovascular hypertensive rat Nattaya Thongsepee, Wilawan Mahabusarakam, Sophapun Ekarattanawong, Umarat Srisawat, Pongsakorn Martviset, Noppadon Suttirak, Siriphun Hiranyachattada, The hexane insoluble fraction of the Garcinia dulcis (GD) flower extract comprises mainly camboginol and morelloflavone which possess potent in vivo and in vitro antioxidant properties. This study aimed to evaluate the effects of 4-week oral administration of GD flower extract on the arterial blood pressure (ABP) and the excretory function of the kidney in the 2-kidneys-1-clip (2K1C) renovascular hypertensive rats (total=12) compared to sham operated (SO) normotensive Wistar rats (total=12). Four weeks after hypertensive-induced surgery, either 50 mg/kg BW GD flower extract or vehicle was orally administered to the 2K1C or SO groups (n=6/group) daily for four weeks. ABP and the renal excretory function were studied in anesthetized rats, and expression of endothelial nitric oxide synthase (eNOS) mRNA in the isolated thoracic aorta were measured. In the 2K1C rats, GD flower extract significantly decreased ABP while increased significantly eNOS mRNA levels. GD flower extract did not exert a diuretic effect in either SO and 2K1C rats since there was no change in observed urine excretion, but it did tend to attenuated the renal tubular damage caused by renovascular hypertension. GD flower extract was anti-hypertensive in this model of renovascular hypertension and problably acts via the endothelial nitric oxide signaling pathway. Penerbit Universiti Kebangsaan Malaysia 2022-03 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/19169/1/18.pdf Nattaya Thongsepee, and Wilawan Mahabusarakam, and Sophapun Ekarattanawong, and Umarat Srisawat, and Pongsakorn Martviset, and Noppadon Suttirak, and Siriphun Hiranyachattada, (2022) Oral administration of Garcinia dulcis flower extract lowers arterial blood pressure of 2-kidneys-1-clip renovascular hypertensive rat. Sains Malaysiana, 51 (3). pp. 847-858. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid51bil3_2022/KandunganJilid51Bil3_2022.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The hexane insoluble fraction of the Garcinia dulcis (GD) flower extract comprises mainly camboginol and morelloflavone which possess potent in vivo and in vitro antioxidant properties. This study aimed to evaluate the effects of 4-week oral administration of GD flower extract on the arterial blood pressure (ABP) and the excretory function of the kidney in the 2-kidneys-1-clip (2K1C) renovascular hypertensive rats (total=12) compared to sham operated (SO) normotensive Wistar rats (total=12). Four weeks after hypertensive-induced surgery, either 50 mg/kg BW GD flower extract or vehicle was orally administered to the 2K1C or SO groups (n=6/group) daily for four weeks. ABP and the renal excretory function were studied in anesthetized rats, and expression of endothelial nitric oxide synthase (eNOS) mRNA in the isolated thoracic aorta were measured. In the 2K1C rats, GD flower extract significantly decreased ABP while increased significantly eNOS mRNA levels. GD flower extract did not exert a diuretic effect in either SO and 2K1C rats since there was no change in observed urine excretion, but it did tend to attenuated the renal tubular damage caused by renovascular hypertension. GD flower extract was anti-hypertensive in this model of renovascular hypertension and problably acts via the endothelial nitric oxide signaling pathway.
format Article
author Nattaya Thongsepee,
Wilawan Mahabusarakam,
Sophapun Ekarattanawong,
Umarat Srisawat,
Pongsakorn Martviset,
Noppadon Suttirak,
Siriphun Hiranyachattada,
spellingShingle Nattaya Thongsepee,
Wilawan Mahabusarakam,
Sophapun Ekarattanawong,
Umarat Srisawat,
Pongsakorn Martviset,
Noppadon Suttirak,
Siriphun Hiranyachattada,
Oral administration of Garcinia dulcis flower extract lowers arterial blood pressure of 2-kidneys-1-clip renovascular hypertensive rat
author_facet Nattaya Thongsepee,
Wilawan Mahabusarakam,
Sophapun Ekarattanawong,
Umarat Srisawat,
Pongsakorn Martviset,
Noppadon Suttirak,
Siriphun Hiranyachattada,
author_sort Nattaya Thongsepee,
title Oral administration of Garcinia dulcis flower extract lowers arterial blood pressure of 2-kidneys-1-clip renovascular hypertensive rat
title_short Oral administration of Garcinia dulcis flower extract lowers arterial blood pressure of 2-kidneys-1-clip renovascular hypertensive rat
title_full Oral administration of Garcinia dulcis flower extract lowers arterial blood pressure of 2-kidneys-1-clip renovascular hypertensive rat
title_fullStr Oral administration of Garcinia dulcis flower extract lowers arterial blood pressure of 2-kidneys-1-clip renovascular hypertensive rat
title_full_unstemmed Oral administration of Garcinia dulcis flower extract lowers arterial blood pressure of 2-kidneys-1-clip renovascular hypertensive rat
title_sort oral administration of garcinia dulcis flower extract lowers arterial blood pressure of 2-kidneys-1-clip renovascular hypertensive rat
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2022
url http://journalarticle.ukm.my/19169/1/18.pdf
http://journalarticle.ukm.my/19169/
https://www.ukm.my/jsm/malay_journals/jilid51bil3_2022/KandunganJilid51Bil3_2022.html
_version_ 1740826820005068800
score 13.211869

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