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Biphenotypic acute leukemia: a report of two cases

We report two cases of biphenotypic acute leukaemia diagnosed in Hospital Universiti Kebangsaan Malaysia (HUKM), their clinical, haematological characteristics and response to chemotherapy. Both patients are middle-aged ladies who presented with hepatosplenomegaly and high white cell count, mainly c...

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Main Authors: RZ Azma,, NH Hamidah,, C-F Leong,, Fadilah SAW,, O Ainoon,, Salwati S,, S-K Cheong,, Sharifah N A,
Format: Article
Language:English
Published: Penerbit UKM 2006
Online Access:http://journalarticle.ukm.my/1886/1/09._53-60_%28MH_016%29.pdf
http://journalarticle.ukm.my/1886/
http://www.ppukm.ukm.my/ukmmcjournal/index.php
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spelling my-ukm.journal.18862016-12-14T06:30:22Z http://journalarticle.ukm.my/1886/ Biphenotypic acute leukemia: a report of two cases RZ Azma, NH Hamidah, C-F Leong, Fadilah SAW, O Ainoon, Salwati S, S-K Cheong, Sharifah N A, We report two cases of biphenotypic acute leukaemia diagnosed in Hospital Universiti Kebangsaan Malaysia (HUKM), their clinical, haematological characteristics and response to chemotherapy. Both patients are middle-aged ladies who presented with hepatosplenomegaly and high white cell count, mainly composed of blast cells. Their bone marrow aspirations were hypercellular comprising of more than 90% heterogenous blast cells. Cytochemical analyses show more than 3% positivity towards peroxidase, with smaller blasts showing block positivity towards PAS. Immunophenotypically, the blasts showed dual expression of CD 33 and CD 19, CD 19 and CD34, intra CD22, intra TdT and intraMPO. One of the patients showed presence of the Philadelphia chromosome on cytogenetic analysis which was confirmed by Fluorecsence In Situ Hybridisation (FISH). Molecular analysis also showed presence of the BCR-ABL fusion protein. Both patients were given combination chemotherapy consisting of daunorubicin and cytosine arabinoside.However, the patient with positive Philadelphia chromosome BCR-ABL did not achieve morphological remission after induction chemotherapy. In view of the poor prognosis of this disease, both the patients were planned for upfront peripheral blood stem cell transplantation Penerbit UKM 2006 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1886/1/09._53-60_%28MH_016%29.pdf RZ Azma, and NH Hamidah, and C-F Leong, and Fadilah SAW, and O Ainoon, and Salwati S, and S-K Cheong, and Sharifah N A, (2006) Biphenotypic acute leukemia: a report of two cases. Medicine & Health, 1 (1). http://www.ppukm.ukm.my/ukmmcjournal/index.php
institution Universiti Kebangsaan Malaysia
building Perpustakaan Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description We report two cases of biphenotypic acute leukaemia diagnosed in Hospital Universiti Kebangsaan Malaysia (HUKM), their clinical, haematological characteristics and response to chemotherapy. Both patients are middle-aged ladies who presented with hepatosplenomegaly and high white cell count, mainly composed of blast cells. Their bone marrow aspirations were hypercellular comprising of more than 90% heterogenous blast cells. Cytochemical analyses show more than 3% positivity towards peroxidase, with smaller blasts showing block positivity towards PAS. Immunophenotypically, the blasts showed dual expression of CD 33 and CD 19, CD 19 and CD34, intra CD22, intra TdT and intraMPO. One of the patients showed presence of the Philadelphia chromosome on cytogenetic analysis which was confirmed by Fluorecsence In Situ Hybridisation (FISH). Molecular analysis also showed presence of the BCR-ABL fusion protein. Both patients were given combination chemotherapy consisting of daunorubicin and cytosine arabinoside.However, the patient with positive Philadelphia chromosome BCR-ABL did not achieve morphological remission after induction chemotherapy. In view of the poor prognosis of this disease, both the patients were planned for upfront peripheral blood stem cell transplantation
format Article
author RZ Azma,
NH Hamidah,
C-F Leong,
Fadilah SAW,
O Ainoon,
Salwati S,
S-K Cheong,
Sharifah N A,
spellingShingle RZ Azma,
NH Hamidah,
C-F Leong,
Fadilah SAW,
O Ainoon,
Salwati S,
S-K Cheong,
Sharifah N A,
Biphenotypic acute leukemia: a report of two cases
author_facet RZ Azma,
NH Hamidah,
C-F Leong,
Fadilah SAW,
O Ainoon,
Salwati S,
S-K Cheong,
Sharifah N A,
author_sort RZ Azma,
title Biphenotypic acute leukemia: a report of two cases
title_short Biphenotypic acute leukemia: a report of two cases
title_full Biphenotypic acute leukemia: a report of two cases
title_fullStr Biphenotypic acute leukemia: a report of two cases
title_full_unstemmed Biphenotypic acute leukemia: a report of two cases
title_sort biphenotypic acute leukemia: a report of two cases
publisher Penerbit UKM
publishDate 2006
url http://journalarticle.ukm.my/1886/1/09._53-60_%28MH_016%29.pdf
http://journalarticle.ukm.my/1886/
http://www.ppukm.ukm.my/ukmmcjournal/index.php
_version_ 1643735191780327424
score 13.211869

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