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Antihyperglycemic and androgenic properties of Moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats

Moringa oleifera leaves were essential for lowering blood glucose levels and increasing androgen levels. This study evaluates the antihyperglycemic properties of Moringa oleifera (MO) leaves aqueous extract and its effect on diabetes-induced male Sprague Dawley rats in attenuating sexual dysfuncti...

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Main Authors: Nurul Ain Kamar Bashah,, Mahanem Mat Noor,
格式: Article
語言:English
出版: Penerbit Universiti Kebangsaan Malaysia 2021
在線閱讀:http://journalarticle.ukm.my/18819/1/099-105%2B%2B%2BMahanem%2BMat%2BNoor.pdf
http://journalarticle.ukm.my/18819/
https://jms.mabjournal.com/index.php/mab/issue/view/36
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spelling my-ukm.journal.188192022-06-24T00:42:51Z http://journalarticle.ukm.my/18819/ Antihyperglycemic and androgenic properties of Moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats Nurul Ain Kamar Bashah, Mahanem Mat Noor, Moringa oleifera leaves were essential for lowering blood glucose levels and increasing androgen levels. This study evaluates the antihyperglycemic properties of Moringa oleifera (MO) leaves aqueous extract and its effect on diabetes-induced male Sprague Dawley rats in attenuating sexual dysfunction. A total of 40 mature male rats were divided into four main groups which were normal control group that received 1 mL of distilled water, the negative control group which did not receive any treatment, positive control group that received 500 mg/kg body weight of metformin, and MO treated group that received 400 mg/kg body weight of Moringa oleifera leaves aqueous extract. All groups were analyzed after 14 and 21 days for their fasting blood glucose level (FBGL) and sexual behavior (mounting latency and mounting frequency). Analysis of testosterone level was also conducted using the testosterone kit of enzyme-linked immunosorbent assay (ELISA). The data of the treatment group were compared to the control group subjected to one-way ANOVA using IBM SPSS Statistics 22 analysis. The FBGL of diabetes-induced rats treated with Moringa oleifera leaves aqueous extract significantly decreased (p<0.05) and the plasma testosterone level increased (p<0.05) compared to the negative and positive control groups. Diabetesinduced rats treated with Moringa oleifera leaves aqueous extract also showed a significant decrease (p<0.05) in mounting latency and increase (p<0.05) in mounting frequency within 15 min of the observation period. This study demonstrated that Moringa oleifera leaves aqueous extract could reduce FBGL significantly and improve the sexual dysfunction of diabetesinduced male rats. Penerbit Universiti Kebangsaan Malaysia 2021 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/18819/1/099-105%2B%2B%2BMahanem%2BMat%2BNoor.pdf Nurul Ain Kamar Bashah, and Mahanem Mat Noor, (2021) Antihyperglycemic and androgenic properties of Moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats. Malaysian Applied Biology, 50 (2). pp. 99-105. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/issue/view/36
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Moringa oleifera leaves were essential for lowering blood glucose levels and increasing androgen levels. This study evaluates the antihyperglycemic properties of Moringa oleifera (MO) leaves aqueous extract and its effect on diabetes-induced male Sprague Dawley rats in attenuating sexual dysfunction. A total of 40 mature male rats were divided into four main groups which were normal control group that received 1 mL of distilled water, the negative control group which did not receive any treatment, positive control group that received 500 mg/kg body weight of metformin, and MO treated group that received 400 mg/kg body weight of Moringa oleifera leaves aqueous extract. All groups were analyzed after 14 and 21 days for their fasting blood glucose level (FBGL) and sexual behavior (mounting latency and mounting frequency). Analysis of testosterone level was also conducted using the testosterone kit of enzyme-linked immunosorbent assay (ELISA). The data of the treatment group were compared to the control group subjected to one-way ANOVA using IBM SPSS Statistics 22 analysis. The FBGL of diabetes-induced rats treated with Moringa oleifera leaves aqueous extract significantly decreased (p<0.05) and the plasma testosterone level increased (p<0.05) compared to the negative and positive control groups. Diabetesinduced rats treated with Moringa oleifera leaves aqueous extract also showed a significant decrease (p<0.05) in mounting latency and increase (p<0.05) in mounting frequency within 15 min of the observation period. This study demonstrated that Moringa oleifera leaves aqueous extract could reduce FBGL significantly and improve the sexual dysfunction of diabetesinduced male rats.
format Article
author Nurul Ain Kamar Bashah,
Mahanem Mat Noor,
spellingShingle Nurul Ain Kamar Bashah,
Mahanem Mat Noor,
Antihyperglycemic and androgenic properties of Moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats
author_facet Nurul Ain Kamar Bashah,
Mahanem Mat Noor,
author_sort Nurul Ain Kamar Bashah,
title Antihyperglycemic and androgenic properties of Moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats
title_short Antihyperglycemic and androgenic properties of Moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats
title_full Antihyperglycemic and androgenic properties of Moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats
title_fullStr Antihyperglycemic and androgenic properties of Moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats
title_full_unstemmed Antihyperglycemic and androgenic properties of Moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats
title_sort antihyperglycemic and androgenic properties of moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2021
url http://journalarticle.ukm.my/18819/1/099-105%2B%2B%2BMahanem%2BMat%2BNoor.pdf
http://journalarticle.ukm.my/18819/
https://jms.mabjournal.com/index.php/mab/issue/view/36
_version_ 1736834970021789696
score 13.250246

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