Antihyperglycemic and androgenic properties of Moringa oleifera leaves aqueous extract attenuate sexual dysfunction in diabetes-induced male rats
Moringa oleifera leaves were essential for lowering blood glucose levels and increasing androgen levels. This study evaluates the antihyperglycemic properties of Moringa oleifera (MO) leaves aqueous extract and its effect on diabetes-induced male Sprague Dawley rats in attenuating sexual dysfuncti...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/18819/1/099-105%2B%2B%2BMahanem%2BMat%2BNoor.pdf http://journalarticle.ukm.my/18819/ https://jms.mabjournal.com/index.php/mab/issue/view/36 |
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| Summary: | Moringa oleifera leaves were essential for lowering blood glucose levels and increasing androgen levels. This study evaluates
the antihyperglycemic properties of Moringa oleifera (MO) leaves aqueous extract and its effect on diabetes-induced male
Sprague Dawley rats in attenuating sexual dysfunction. A total of 40 mature male rats were divided into four main groups
which were normal control group that received 1 mL of distilled water, the negative control group which did not receive
any treatment, positive control group that received 500 mg/kg body weight of metformin, and MO treated group that
received 400 mg/kg body weight of Moringa oleifera leaves aqueous extract. All groups were analyzed after 14 and 21 days
for their fasting blood glucose level (FBGL) and sexual behavior (mounting latency and mounting frequency). Analysis of
testosterone level was also conducted using the testosterone kit of enzyme-linked immunosorbent assay (ELISA). The
data of the treatment group were compared to the control group subjected to one-way ANOVA using IBM SPSS Statistics
22 analysis. The FBGL of diabetes-induced rats treated with Moringa oleifera leaves aqueous extract significantly decreased
(p<0.05) and the plasma testosterone level increased (p<0.05) compared to the negative and positive control groups. Diabetesinduced
rats treated with Moringa oleifera leaves aqueous extract also showed a significant decrease (p<0.05) in mounting
latency and increase (p<0.05) in mounting frequency within 15 min of the observation period. This study demonstrated
that Moringa oleifera leaves aqueous extract could reduce FBGL significantly and improve the sexual dysfunction of diabetesinduced
male rats. |
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