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Simulation study on the effect of dielectrophoresis force on a separation of platelet from blood cell in a 3D mini channel

In recent years, separation of platelet from a blood cell received growing attention due to its usages for blood disorders or any disease treatment. However, the conventional separation techniques have some constraint due to its limitation to separate the cells with similar properties, costly, requi...

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Main Authors: Nur Tantiyani Ali Othman,, Lee, C. S.
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2021
Online Access:http://journalarticle.ukm.my/17807/1/10.pdf
http://journalarticle.ukm.my/17807/
https://www.ukm.my/jkukm/volume-332-2021/
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spelling my-ukm.journal.178072022-01-02T07:38:25Z http://journalarticle.ukm.my/17807/ Simulation study on the effect of dielectrophoresis force on a separation of platelet from blood cell in a 3D mini channel Nur Tantiyani Ali Othman, Lee, C. S. In recent years, separation of platelet from a blood cell received growing attention due to its usages for blood disorders or any disease treatment. However, the conventional separation techniques have some constraint due to its limitation to separate the cells with similar properties, costly, requires longer processing time, and less data accuracy. Thus, under the effect of a uniform electric field, a dielectrophoretic (DEP) force was applied as its ability to separate on a similar diameter size of cells, has lower cost, and requires only a small volume of sample. In this study, a 3D mini channel model with a Y-shape was developed using AutoCAD® and the velocity profile distribution was observed using ANSYS© Fluent version 19.1. Three parameters were observed at various an electric field intensity; E=±1 to ±5 V/mm, an electric field frequency, f=1 kHz to 1 MHz and a particle diameter; d=1.3 to 2.0μm. The results show the velocity was increased as the higher of electric field intensity and larger particle diameter. Besides, the DEP force was increased as the higher electric field intensity was charged for all tested frequencies. As well, as the higher the electric field intensity charged and the larger the particle diameter, the stronger of the DEP force. It can be concluded that the DEP force at d=2.0μm and E=5 V/mm was the optimum conditions and obtained the highest result among all the tested parameters. Under these optimum conditions, it shows the DEP force can separate the platelet from the blood cells. Penerbit Universiti Kebangsaan Malaysia 2021 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17807/1/10.pdf Nur Tantiyani Ali Othman, and Lee, C. S. (2021) Simulation study on the effect of dielectrophoresis force on a separation of platelet from blood cell in a 3D mini channel. Jurnal Kejuruteraan, 33 (2). pp. 249-255. ISSN 0128-0198 https://www.ukm.my/jkukm/volume-332-2021/
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description In recent years, separation of platelet from a blood cell received growing attention due to its usages for blood disorders or any disease treatment. However, the conventional separation techniques have some constraint due to its limitation to separate the cells with similar properties, costly, requires longer processing time, and less data accuracy. Thus, under the effect of a uniform electric field, a dielectrophoretic (DEP) force was applied as its ability to separate on a similar diameter size of cells, has lower cost, and requires only a small volume of sample. In this study, a 3D mini channel model with a Y-shape was developed using AutoCAD® and the velocity profile distribution was observed using ANSYS© Fluent version 19.1. Three parameters were observed at various an electric field intensity; E=±1 to ±5 V/mm, an electric field frequency, f=1 kHz to 1 MHz and a particle diameter; d=1.3 to 2.0μm. The results show the velocity was increased as the higher of electric field intensity and larger particle diameter. Besides, the DEP force was increased as the higher electric field intensity was charged for all tested frequencies. As well, as the higher the electric field intensity charged and the larger the particle diameter, the stronger of the DEP force. It can be concluded that the DEP force at d=2.0μm and E=5 V/mm was the optimum conditions and obtained the highest result among all the tested parameters. Under these optimum conditions, it shows the DEP force can separate the platelet from the blood cells.
format Article
author Nur Tantiyani Ali Othman,
Lee, C. S.
spellingShingle Nur Tantiyani Ali Othman,
Lee, C. S.
Simulation study on the effect of dielectrophoresis force on a separation of platelet from blood cell in a 3D mini channel
author_facet Nur Tantiyani Ali Othman,
Lee, C. S.
author_sort Nur Tantiyani Ali Othman,
title Simulation study on the effect of dielectrophoresis force on a separation of platelet from blood cell in a 3D mini channel
title_short Simulation study on the effect of dielectrophoresis force on a separation of platelet from blood cell in a 3D mini channel
title_full Simulation study on the effect of dielectrophoresis force on a separation of platelet from blood cell in a 3D mini channel
title_fullStr Simulation study on the effect of dielectrophoresis force on a separation of platelet from blood cell in a 3D mini channel
title_full_unstemmed Simulation study on the effect of dielectrophoresis force on a separation of platelet from blood cell in a 3D mini channel
title_sort simulation study on the effect of dielectrophoresis force on a separation of platelet from blood cell in a 3d mini channel
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2021
url http://journalarticle.ukm.my/17807/1/10.pdf
http://journalarticle.ukm.my/17807/
https://www.ukm.my/jkukm/volume-332-2021/
_version_ 1720981057347518464
score 13.211869

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