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The effect of type, duration and intensity of exercise on inflammatory markers CRP, IL-6 and IL-18 in metabolic syndrome patients : a systematic review

Metabolic syndrome (MetS) has become a major clinical challenge worldwide due to rise of urbanisation, surplus energy intake, increasing obesity and sedentary lifestyle. C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-18 (IL-18) are associated with MetS. We performed a systematic revi...

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Main Authors: Srijit Dass,, Isa Naina-Mohamed,, S Zulfarina Mohamed,, Hazwan Hazrin Salim,, Azwani Zawawi,, Tarrsini Thevaraj,, Ku Nurmahirah Ku-Ahmad-Nasir,, Kheng, Dennis Zhou, Teoh, Seong Lin
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2021
Online Access:http://journalarticle.ukm.my/17560/1/14.pdf
http://journalarticle.ukm.my/17560/
https://www.ukm.my/jsm/malay_journals/jilid50bil7_2021/KandunganJilid50Bil7_2021.html
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spelling my-ukm.journal.175602021-11-15T03:25:23Z http://journalarticle.ukm.my/17560/ The effect of type, duration and intensity of exercise on inflammatory markers CRP, IL-6 and IL-18 in metabolic syndrome patients : a systematic review Srijit Dass, Isa Naina-Mohamed, S Zulfarina Mohamed, Hazwan Hazrin Salim, Azwani Zawawi, Tarrsini Thevaraj, Ku Nurmahirah Ku-Ahmad-Nasir, Kheng, Dennis Zhou Teoh, Seong Lin Metabolic syndrome (MetS) has become a major clinical challenge worldwide due to rise of urbanisation, surplus energy intake, increasing obesity and sedentary lifestyle. C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-18 (IL-18) are associated with MetS. We performed a systematic review to investigate the effects of exercise on these markers in MetS patients and therefore to determine the best exercise regime for them. We searched Medline (Pubmed and Ovid), Scopus and CINAHL databases. The searches were standardized by using the same search strategy which included the terms such as ‘metabolic syndrome’, ‘CRP’, ‘IL-6’, ‘IL-18’ and ‘exercise’. Only clinical human studies published from Jan 2007 to May 2018 were included. A total of 11 clinical trials (466 participants) were selected. Majority of the studies were randomized controlled studies (90.9%). All studies showed a decrease in serum levels of the biomarkers. However, not all were statistically significant. The main type of exercise in most of the studies was aerobic. Aerobic-resistance exercise was more effective rather than aerobic alone, but aerobic exercise was the only effective as a sole intervention. Aerobic exercise showed promising role as the main lifestyle intervention in MetS. It is concluded that patients with MetS should have combined aerobic-resistance exercise. Penerbit Universiti Kebangsaan Malaysia 2021-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17560/1/14.pdf Srijit Dass, and Isa Naina-Mohamed, and S Zulfarina Mohamed, and Hazwan Hazrin Salim, and Azwani Zawawi, and Tarrsini Thevaraj, and Ku Nurmahirah Ku-Ahmad-Nasir, and Kheng, Dennis Zhou and Teoh, Seong Lin (2021) The effect of type, duration and intensity of exercise on inflammatory markers CRP, IL-6 and IL-18 in metabolic syndrome patients : a systematic review. Sains Malaysiana, 50 (7). pp. 1997-2006. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil7_2021/KandunganJilid50Bil7_2021.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Metabolic syndrome (MetS) has become a major clinical challenge worldwide due to rise of urbanisation, surplus energy intake, increasing obesity and sedentary lifestyle. C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-18 (IL-18) are associated with MetS. We performed a systematic review to investigate the effects of exercise on these markers in MetS patients and therefore to determine the best exercise regime for them. We searched Medline (Pubmed and Ovid), Scopus and CINAHL databases. The searches were standardized by using the same search strategy which included the terms such as ‘metabolic syndrome’, ‘CRP’, ‘IL-6’, ‘IL-18’ and ‘exercise’. Only clinical human studies published from Jan 2007 to May 2018 were included. A total of 11 clinical trials (466 participants) were selected. Majority of the studies were randomized controlled studies (90.9%). All studies showed a decrease in serum levels of the biomarkers. However, not all were statistically significant. The main type of exercise in most of the studies was aerobic. Aerobic-resistance exercise was more effective rather than aerobic alone, but aerobic exercise was the only effective as a sole intervention. Aerobic exercise showed promising role as the main lifestyle intervention in MetS. It is concluded that patients with MetS should have combined aerobic-resistance exercise.
format Article
author Srijit Dass,
Isa Naina-Mohamed,
S Zulfarina Mohamed,
Hazwan Hazrin Salim,
Azwani Zawawi,
Tarrsini Thevaraj,
Ku Nurmahirah Ku-Ahmad-Nasir,
Kheng, Dennis Zhou
Teoh, Seong Lin
spellingShingle Srijit Dass,
Isa Naina-Mohamed,
S Zulfarina Mohamed,
Hazwan Hazrin Salim,
Azwani Zawawi,
Tarrsini Thevaraj,
Ku Nurmahirah Ku-Ahmad-Nasir,
Kheng, Dennis Zhou
Teoh, Seong Lin
The effect of type, duration and intensity of exercise on inflammatory markers CRP, IL-6 and IL-18 in metabolic syndrome patients : a systematic review
author_facet Srijit Dass,
Isa Naina-Mohamed,
S Zulfarina Mohamed,
Hazwan Hazrin Salim,
Azwani Zawawi,
Tarrsini Thevaraj,
Ku Nurmahirah Ku-Ahmad-Nasir,
Kheng, Dennis Zhou
Teoh, Seong Lin
author_sort Srijit Dass,
title The effect of type, duration and intensity of exercise on inflammatory markers CRP, IL-6 and IL-18 in metabolic syndrome patients : a systematic review
title_short The effect of type, duration and intensity of exercise on inflammatory markers CRP, IL-6 and IL-18 in metabolic syndrome patients : a systematic review
title_full The effect of type, duration and intensity of exercise on inflammatory markers CRP, IL-6 and IL-18 in metabolic syndrome patients : a systematic review
title_fullStr The effect of type, duration and intensity of exercise on inflammatory markers CRP, IL-6 and IL-18 in metabolic syndrome patients : a systematic review
title_full_unstemmed The effect of type, duration and intensity of exercise on inflammatory markers CRP, IL-6 and IL-18 in metabolic syndrome patients : a systematic review
title_sort effect of type, duration and intensity of exercise on inflammatory markers crp, il-6 and il-18 in metabolic syndrome patients : a systematic review
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2021
url http://journalarticle.ukm.my/17560/1/14.pdf
http://journalarticle.ukm.my/17560/
https://www.ukm.my/jsm/malay_journals/jilid50bil7_2021/KandunganJilid50Bil7_2021.html
_version_ 1717094736805756928
score 13.211869

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