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Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review

Bone marrow concentrate (BMC) has been emerging as a promising regenerative source to accelerate cartilage regeneration in cartilage injuries and osteoarthritis. Though the number of stem cells in BMC is limited, BMC is rich in growth factors that promote stem cell differentiation and tissue regen...

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Main Authors: Nabillah Abd Radzak,, Malliga Raman Murali,, Tunku Kamarul,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2021
Online Access:http://journalarticle.ukm.my/17537/1/19.pdf
http://journalarticle.ukm.my/17537/
https://www.ukm.my/jsm/malay_journals/jilid50bil6_2021/KandunganJilid50Bil6_2021.html
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spelling my-ukm.journal.175372021-10-26T06:20:12Z http://journalarticle.ukm.my/17537/ Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review Nabillah Abd Radzak, Malliga Raman Murali, Tunku Kamarul, Bone marrow concentrate (BMC) has been emerging as a promising regenerative source to accelerate cartilage regeneration in cartilage injuries and osteoarthritis. Though the number of stem cells in BMC is limited, BMC is rich in growth factors that promote stem cell differentiation and tissue regeneration. Despite of multiple reports available on the use of BMC for cartilage repair in humans and its use in clinical settings, only limited number of pre-clinical proof of concept studies have been reported in animal models. Hence, a systematic review focusing on the potential of BMC for the treatment of cartilage defect in animal models has been conducted. The systematic search of literature using three popular databases, ISI Web of Knowledge, PubMed and Scopus, were conducted without year restriction. Fifteen (n = 15) studies were found appropriate and included in this review. All of the included studies were of different animal models with cartilage defect. 13 out of 15 studies reported that the usage of BMC gave the best outcome compared to other treatment methods. Most of the findings provided good scoring on the tissue repair and the histological outcome. However, most of the BMC group outcomes did not give a significant difference when compared with other interventions such as the addition of platelet rich plasma, erythropoietin, hyaluronic acid, transforming growth factor, autologous tissue implant, genetic modification or scaffoldings. In conclusion, the published studies do suggest that BMC could provide a better cartilage repair. However, more preclinical studies are required to provide definitive conclusions. Penerbit Universiti Kebangsaan Malaysia 2021-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17537/1/19.pdf Nabillah Abd Radzak, and Malliga Raman Murali, and Tunku Kamarul, (2021) Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review. Sains Malaysiana, 50 (6). pp. 1727-1744. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil6_2021/KandunganJilid50Bil6_2021.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Bone marrow concentrate (BMC) has been emerging as a promising regenerative source to accelerate cartilage regeneration in cartilage injuries and osteoarthritis. Though the number of stem cells in BMC is limited, BMC is rich in growth factors that promote stem cell differentiation and tissue regeneration. Despite of multiple reports available on the use of BMC for cartilage repair in humans and its use in clinical settings, only limited number of pre-clinical proof of concept studies have been reported in animal models. Hence, a systematic review focusing on the potential of BMC for the treatment of cartilage defect in animal models has been conducted. The systematic search of literature using three popular databases, ISI Web of Knowledge, PubMed and Scopus, were conducted without year restriction. Fifteen (n = 15) studies were found appropriate and included in this review. All of the included studies were of different animal models with cartilage defect. 13 out of 15 studies reported that the usage of BMC gave the best outcome compared to other treatment methods. Most of the findings provided good scoring on the tissue repair and the histological outcome. However, most of the BMC group outcomes did not give a significant difference when compared with other interventions such as the addition of platelet rich plasma, erythropoietin, hyaluronic acid, transforming growth factor, autologous tissue implant, genetic modification or scaffoldings. In conclusion, the published studies do suggest that BMC could provide a better cartilage repair. However, more preclinical studies are required to provide definitive conclusions.
format Article
author Nabillah Abd Radzak,
Malliga Raman Murali,
Tunku Kamarul,
spellingShingle Nabillah Abd Radzak,
Malliga Raman Murali,
Tunku Kamarul,
Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review
author_facet Nabillah Abd Radzak,
Malliga Raman Murali,
Tunku Kamarul,
author_sort Nabillah Abd Radzak,
title Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review
title_short Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review
title_full Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review
title_fullStr Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review
title_full_unstemmed Assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review
title_sort assessing the potential of bone marrow concentrate for cartilage repair and regeneration in animal models : a systemic review
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2021
url http://journalarticle.ukm.my/17537/1/19.pdf
http://journalarticle.ukm.my/17537/
https://www.ukm.my/jsm/malay_journals/jilid50bil6_2021/KandunganJilid50Bil6_2021.html
_version_ 1715190956354961408
score 13.211869

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