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Comparative analyses of serological biomarkers and disease characteristics between elderly-onset and younger-onset rheumatoid arthritis

The onset of rheumatoid arthritis (RA) may occur any time after the age of 16 years. The purpose of this study was to compare the clinical and serological differences between elderly onset RA (EORA); which is begins at the age of 60 and above, with younger onset RA (YORA). A total of 69 EORA a...

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Main Authors: Rajalingham Sakthiswary,, Syahrul Sazliyana S,, Abdul Wahab A,, Mahadzir H,
Format: Article
Language:English
Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2021
Online Access:http://journalarticle.ukm.my/17450/1/19_ms0488_pdf_20856.pdf
http://journalarticle.ukm.my/17450/
https://www.medicineandhealthukm.com/toc/16/1
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spelling my-ukm.journal.174502021-09-23T04:06:45Z http://journalarticle.ukm.my/17450/ Comparative analyses of serological biomarkers and disease characteristics between elderly-onset and younger-onset rheumatoid arthritis Rajalingham Sakthiswary, Syahrul Sazliyana S, Abdul Wahab A, Mahadzir H, The onset of rheumatoid arthritis (RA) may occur any time after the age of 16 years. The purpose of this study was to compare the clinical and serological differences between elderly onset RA (EORA); which is begins at the age of 60 and above, with younger onset RA (YORA). A total of 69 EORA and 82 YORA female patients were enrolled in this study. Data on medications, disease duration, age at onset, disease activity at onset and laboratory parameters were collected by reviewing the medical records. All patients had their blood samples taken for serum anti-cyclic citrulinated peptide (anti-CCP), IgA rheumatoid factor (RF), IgM RF and IgG RF. Besides, the subjects were assessed for their radiographic joint damage based on Modified Sharp Score (MSS) and functional disability based on the Health Assessment Questionnaire-disability Index (HAQ-DI) scores. Despite comparable disease duration and frequency of seropositivity, the YORA group had significantly higher disease activity at onset of the disease (p=0.009). In keeping with this finding, the YORA group had more severe joint damage based on radiographic assessment (MSS scores of 17.49+19.04 versus 10.04+12.79). The YORA group had significantly higher levels of IgA RF and anti-CCP with p-values of 0.035 and 0.002, respectively. Our findings suggest that YORA is associated with more severe disease, worse radiographic joint damage and higher levels of anti-CCP and IgA RF. Pusat Perubatan Universiti Kebangsaan Malaysia 2021-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17450/1/19_ms0488_pdf_20856.pdf Rajalingham Sakthiswary, and Syahrul Sazliyana S, and Abdul Wahab A, and Mahadzir H, (2021) Comparative analyses of serological biomarkers and disease characteristics between elderly-onset and younger-onset rheumatoid arthritis. Medicine & Health, 16 (1). pp. 237-245. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/16/1
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The onset of rheumatoid arthritis (RA) may occur any time after the age of 16 years. The purpose of this study was to compare the clinical and serological differences between elderly onset RA (EORA); which is begins at the age of 60 and above, with younger onset RA (YORA). A total of 69 EORA and 82 YORA female patients were enrolled in this study. Data on medications, disease duration, age at onset, disease activity at onset and laboratory parameters were collected by reviewing the medical records. All patients had their blood samples taken for serum anti-cyclic citrulinated peptide (anti-CCP), IgA rheumatoid factor (RF), IgM RF and IgG RF. Besides, the subjects were assessed for their radiographic joint damage based on Modified Sharp Score (MSS) and functional disability based on the Health Assessment Questionnaire-disability Index (HAQ-DI) scores. Despite comparable disease duration and frequency of seropositivity, the YORA group had significantly higher disease activity at onset of the disease (p=0.009). In keeping with this finding, the YORA group had more severe joint damage based on radiographic assessment (MSS scores of 17.49+19.04 versus 10.04+12.79). The YORA group had significantly higher levels of IgA RF and anti-CCP with p-values of 0.035 and 0.002, respectively. Our findings suggest that YORA is associated with more severe disease, worse radiographic joint damage and higher levels of anti-CCP and IgA RF.
format Article
author Rajalingham Sakthiswary,
Syahrul Sazliyana S,
Abdul Wahab A,
Mahadzir H,
spellingShingle Rajalingham Sakthiswary,
Syahrul Sazliyana S,
Abdul Wahab A,
Mahadzir H,
Comparative analyses of serological biomarkers and disease characteristics between elderly-onset and younger-onset rheumatoid arthritis
author_facet Rajalingham Sakthiswary,
Syahrul Sazliyana S,
Abdul Wahab A,
Mahadzir H,
author_sort Rajalingham Sakthiswary,
title Comparative analyses of serological biomarkers and disease characteristics between elderly-onset and younger-onset rheumatoid arthritis
title_short Comparative analyses of serological biomarkers and disease characteristics between elderly-onset and younger-onset rheumatoid arthritis
title_full Comparative analyses of serological biomarkers and disease characteristics between elderly-onset and younger-onset rheumatoid arthritis
title_fullStr Comparative analyses of serological biomarkers and disease characteristics between elderly-onset and younger-onset rheumatoid arthritis
title_full_unstemmed Comparative analyses of serological biomarkers and disease characteristics between elderly-onset and younger-onset rheumatoid arthritis
title_sort comparative analyses of serological biomarkers and disease characteristics between elderly-onset and younger-onset rheumatoid arthritis
publisher Pusat Perubatan Universiti Kebangsaan Malaysia
publishDate 2021
url http://journalarticle.ukm.my/17450/1/19_ms0488_pdf_20856.pdf
http://journalarticle.ukm.my/17450/
https://www.medicineandhealthukm.com/toc/16/1
_version_ 1712286242838675456
score 13.211869

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