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Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture

Ginger has been proven to possess various therapeutic effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant effects. However, data on the comparison of ginger antioxidant activity with that of other natural products are still lacking. This study aimed to analyse and co...

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Main Authors: Nur Fatin Nabilah Mohd Sahardi,, Faizul Jaafar,, Siti Nor Asyikin Zakaria,, Tan, Jen Kit, Mariam Firdhaus Mad Nordin,, Suzana Makpol,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2021
Online Access:http://journalarticle.ukm.my/17420/1/23.pdf
http://journalarticle.ukm.my/17420/
https://www.ukm.my/jsm/malay_journals/jilid50bil5_2021/KandunganJilid50Bil5_2021.html
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spelling my-ukm.journal.174202021-09-14T03:13:02Z http://journalarticle.ukm.my/17420/ Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture Nur Fatin Nabilah Mohd Sahardi, Faizul Jaafar, Siti Nor Asyikin Zakaria, Tan, Jen Kit Mariam Firdhaus Mad Nordin, Suzana Makpol, Ginger has been proven to possess various therapeutic effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant effects. However, data on the comparison of ginger antioxidant activity with that of other natural products are still lacking. This study aimed to analyse and compare the antioxidant properties of two types of Malaysian ginger extracts (GE1 and GE2) with that of selected natural products. The antioxidant activities were measured by 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and ferric reducing antioxidant power (FRAP) assays, while cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfonyl)-2H-tetrazolium (MTS) assay. The order of the DPPH scavenging activities was as follows: vitamin C > palm tocotrienol-rich fraction (TRF) > α-tocopherol > N-acetylcysteine (NAC) > Ficus deltoidea > butylated hydroxytoluene (BHT) > Centella asiatica > GE2 > GE1 > Moringa oleifera > Kelulut honey; the order of the mean FRAP value was as follows: NAC > α-tocopherol > BHT > TRF > Ficus deltoidea > Moringa oleifera > GE2 = GE1 > Centella asiatica > Kelulut honey. The viability assays showed that both ginger extracts significantly increased the percentage of viable cells (p < 0.05). In conclusion, neither of the ginger extracts was cytotoxic toward cells and both possessed comparable antioxidant properties, indicating their potential for ameliorating oxidative stress. Penerbit Universiti Kebangsaan Malaysia 2021-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17420/1/23.pdf Nur Fatin Nabilah Mohd Sahardi, and Faizul Jaafar, and Siti Nor Asyikin Zakaria, and Tan, Jen Kit and Mariam Firdhaus Mad Nordin, and Suzana Makpol, (2021) Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture. Sains Malaysiana, 50 (5). pp. 1445-1456. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil5_2021/KandunganJilid50Bil5_2021.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Ginger has been proven to possess various therapeutic effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant effects. However, data on the comparison of ginger antioxidant activity with that of other natural products are still lacking. This study aimed to analyse and compare the antioxidant properties of two types of Malaysian ginger extracts (GE1 and GE2) with that of selected natural products. The antioxidant activities were measured by 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and ferric reducing antioxidant power (FRAP) assays, while cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfonyl)-2H-tetrazolium (MTS) assay. The order of the DPPH scavenging activities was as follows: vitamin C > palm tocotrienol-rich fraction (TRF) > α-tocopherol > N-acetylcysteine (NAC) > Ficus deltoidea > butylated hydroxytoluene (BHT) > Centella asiatica > GE2 > GE1 > Moringa oleifera > Kelulut honey; the order of the mean FRAP value was as follows: NAC > α-tocopherol > BHT > TRF > Ficus deltoidea > Moringa oleifera > GE2 = GE1 > Centella asiatica > Kelulut honey. The viability assays showed that both ginger extracts significantly increased the percentage of viable cells (p < 0.05). In conclusion, neither of the ginger extracts was cytotoxic toward cells and both possessed comparable antioxidant properties, indicating their potential for ameliorating oxidative stress.
format Article
author Nur Fatin Nabilah Mohd Sahardi,
Faizul Jaafar,
Siti Nor Asyikin Zakaria,
Tan, Jen Kit
Mariam Firdhaus Mad Nordin,
Suzana Makpol,
spellingShingle Nur Fatin Nabilah Mohd Sahardi,
Faizul Jaafar,
Siti Nor Asyikin Zakaria,
Tan, Jen Kit
Mariam Firdhaus Mad Nordin,
Suzana Makpol,
Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
author_facet Nur Fatin Nabilah Mohd Sahardi,
Faizul Jaafar,
Siti Nor Asyikin Zakaria,
Tan, Jen Kit
Mariam Firdhaus Mad Nordin,
Suzana Makpol,
author_sort Nur Fatin Nabilah Mohd Sahardi,
title Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
title_short Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
title_full Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
title_fullStr Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
title_full_unstemmed Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
title_sort comparison of the antioxidant activity of malaysian ginger (zingiber officinale roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2021
url http://journalarticle.ukm.my/17420/1/23.pdf
http://journalarticle.ukm.my/17420/
https://www.ukm.my/jsm/malay_journals/jilid50bil5_2021/KandunganJilid50Bil5_2021.html
_version_ 1712286238715674624
score 13.211869

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