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Lower cut off point for blood lead and risk of myocardial infarction at a tertiary hospital in Malaysia: a case-control study

Introduction. Lead (Pb) is one of the pollutants that can cause adverse effects on human health. Exposure to Pb has received much attention in the past decades due to its nearly persistent properties in the environment. Blood Pb measurement is the most convenient as well as most feasible to indicate...

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Main Authors: Rusna Meswari,, Mohd Hasni Jaáfar,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2021
Online Access:http://journalarticle.ukm.my/16672/1/269-Article%20Text-1688-1-10-20210311.pdf
http://journalarticle.ukm.my/16672/
http://spaj.ukm.my/ijphr/index.php/ijphr/issue/view/28
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spelling my-ukm.journal.166722021-06-02T06:15:52Z http://journalarticle.ukm.my/16672/ Lower cut off point for blood lead and risk of myocardial infarction at a tertiary hospital in Malaysia: a case-control study Rusna Meswari, Mohd Hasni Jaáfar, Introduction. Lead (Pb) is one of the pollutants that can cause adverse effects on human health. Exposure to Pb has received much attention in the past decades due to its nearly persistent properties in the environment. Blood Pb measurement is the most convenient as well as most feasible to indicate toxicity exceeded the standard limit of 10 μg/dL. This study aimed to assess the association between blood Pb and myocardial infarction. Methodology. This was a case-control study conducted at a tertiary hospital in Kuala Lumpur, Malaysia. This study enrolled about 109 respondents; 71 cases of myocardial infarction and 38 non-cases of myocardial infarction. Study instruments include questionnaires on demographic factors (age, gender, and ethnicity), socioeconomic factors (education, household income, occupation), and venous blood lead level. The blood Pb was measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Result. The median (IQR) of blood Pb among the case group was higher compared to the control groups, 3.72 (0.04 – 96.09) μg/dL and 2.81 (0.73 – 6.23) μg/dL respectively. No difference between high (> 10 μg/dL) and normal ( <10 μg/dL) blood Pb with CVD. However, there was a significant association between high normal blood Pb concentration (≥ 5.00 µg/dL) and myocardial infarction (χ2 = 4.397; p = 0.036). Conclusion. There is a relationship between lower blood Pb level and the occurrence of myocardial infarction. No difference was found between the blood Pb limit of 10 μg/dL and CVD. The findings of this study are very important and provide new information regarding the lower cut of point for blood Pb and outcome of CVD especially myocardial infarction. Penerbit Universiti Kebangsaan Malaysia 2021 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/16672/1/269-Article%20Text-1688-1-10-20210311.pdf Rusna Meswari, and Mohd Hasni Jaáfar, (2021) Lower cut off point for blood lead and risk of myocardial infarction at a tertiary hospital in Malaysia: a case-control study. International Journal of Public Health Research, 11 (1). pp. 1293-1297. ISSN 2232-0245 http://spaj.ukm.my/ijphr/index.php/ijphr/issue/view/28
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Introduction. Lead (Pb) is one of the pollutants that can cause adverse effects on human health. Exposure to Pb has received much attention in the past decades due to its nearly persistent properties in the environment. Blood Pb measurement is the most convenient as well as most feasible to indicate toxicity exceeded the standard limit of 10 μg/dL. This study aimed to assess the association between blood Pb and myocardial infarction. Methodology. This was a case-control study conducted at a tertiary hospital in Kuala Lumpur, Malaysia. This study enrolled about 109 respondents; 71 cases of myocardial infarction and 38 non-cases of myocardial infarction. Study instruments include questionnaires on demographic factors (age, gender, and ethnicity), socioeconomic factors (education, household income, occupation), and venous blood lead level. The blood Pb was measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Result. The median (IQR) of blood Pb among the case group was higher compared to the control groups, 3.72 (0.04 – 96.09) μg/dL and 2.81 (0.73 – 6.23) μg/dL respectively. No difference between high (> 10 μg/dL) and normal ( <10 μg/dL) blood Pb with CVD. However, there was a significant association between high normal blood Pb concentration (≥ 5.00 µg/dL) and myocardial infarction (χ2 = 4.397; p = 0.036). Conclusion. There is a relationship between lower blood Pb level and the occurrence of myocardial infarction. No difference was found between the blood Pb limit of 10 μg/dL and CVD. The findings of this study are very important and provide new information regarding the lower cut of point for blood Pb and outcome of CVD especially myocardial infarction.
format Article
author Rusna Meswari,
Mohd Hasni Jaáfar,
spellingShingle Rusna Meswari,
Mohd Hasni Jaáfar,
Lower cut off point for blood lead and risk of myocardial infarction at a tertiary hospital in Malaysia: a case-control study
author_facet Rusna Meswari,
Mohd Hasni Jaáfar,
author_sort Rusna Meswari,
title Lower cut off point for blood lead and risk of myocardial infarction at a tertiary hospital in Malaysia: a case-control study
title_short Lower cut off point for blood lead and risk of myocardial infarction at a tertiary hospital in Malaysia: a case-control study
title_full Lower cut off point for blood lead and risk of myocardial infarction at a tertiary hospital in Malaysia: a case-control study
title_fullStr Lower cut off point for blood lead and risk of myocardial infarction at a tertiary hospital in Malaysia: a case-control study
title_full_unstemmed Lower cut off point for blood lead and risk of myocardial infarction at a tertiary hospital in Malaysia: a case-control study
title_sort lower cut off point for blood lead and risk of myocardial infarction at a tertiary hospital in malaysia: a case-control study
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2021
url http://journalarticle.ukm.my/16672/1/269-Article%20Text-1688-1-10-20210311.pdf
http://journalarticle.ukm.my/16672/
http://spaj.ukm.my/ijphr/index.php/ijphr/issue/view/28
_version_ 1702170861953351680
score 13.211869

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