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Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens

This study was performed to investigate the theraputic efficacy of toltrazuril, sulfaclozine sodium and their combination in broiler chicken for the treatment of experimentally induced caecal coccidiosis. For this purpose, seventy-five day-old chicks were randomly divided into five equal groups (1...

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Main Authors: Hagag, Dina, El-Shazly, Kamal, Abd El-Aziz, Magdy, Abd El-Latif, Amira, El Sharkaway, Hanem, Abdo, Walied, Barakat, Mohamed
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2020
Online Access:http://journalarticle.ukm.my/15994/1/3.pdf
http://journalarticle.ukm.my/15994/
https://www.ukm.my/jsm/malay_journals/jilid49bil11_2020/KandunganJilid49Bil11_2020.html
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spelling my-ukm.journal.159942020-12-17T04:41:50Z http://journalarticle.ukm.my/15994/ Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens Hagag, Dina El-Shazly, Kamal Abd El-Aziz, Magdy Abd El-Latif, Amira El Sharkaway, Hanem Abdo, Walied Barakat, Mohamed This study was performed to investigate the theraputic efficacy of toltrazuril, sulfaclozine sodium and their combination in broiler chicken for the treatment of experimentally induced caecal coccidiosis. For this purpose, seventy-five day-old chicks were randomly divided into five equal groups (15 each). G1 , kept as control negative; G2 , infected non treated (control positive); G3 , infected treated with toltrazuril (1 mL/L); G4 , infected treated with sodium sulfaclozine (2 mL/L); G5 , infected treated with toltrazuril (1 mL/L) + sulfaclozine Na (2 g/L). All groups except negative control group were inoculated orally with 5 × 104 sporulated oocysts of Eimeria tenella (field isolate) on the day 15th of age. According to the present results, G2 showed a significant increase in oocyst count, AST, ALT, ALP, uric acid, and creatinine, with significant decrease in body weight gain, hematological parameters, total protein, and albumin. Treatment decreased the harmful effect of infection but some significant differences were shown between infected and treated groups and non infected and non treated group in assessment criteria. Furthermore, the histopathological findings were also discussed. In conclusion, the current study showed that the application of both tested drugs gave significant and satisfactory improvement in the assessment criteria as well as they are effective in control of coccidiosis caused by Eimeria tenella. Penerbit Universiti Kebangsaan Malaysia 2020-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15994/1/3.pdf Hagag, Dina and El-Shazly, Kamal and Abd El-Aziz, Magdy and Abd El-Latif, Amira and El Sharkaway, Hanem and Abdo, Walied and Barakat, Mohamed (2020) Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens. Sains Malaysiana, 49 (11). pp. 2637-2648. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid49bil11_2020/KandunganJilid49Bil11_2020.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description This study was performed to investigate the theraputic efficacy of toltrazuril, sulfaclozine sodium and their combination in broiler chicken for the treatment of experimentally induced caecal coccidiosis. For this purpose, seventy-five day-old chicks were randomly divided into five equal groups (15 each). G1 , kept as control negative; G2 , infected non treated (control positive); G3 , infected treated with toltrazuril (1 mL/L); G4 , infected treated with sodium sulfaclozine (2 mL/L); G5 , infected treated with toltrazuril (1 mL/L) + sulfaclozine Na (2 g/L). All groups except negative control group were inoculated orally with 5 × 104 sporulated oocysts of Eimeria tenella (field isolate) on the day 15th of age. According to the present results, G2 showed a significant increase in oocyst count, AST, ALT, ALP, uric acid, and creatinine, with significant decrease in body weight gain, hematological parameters, total protein, and albumin. Treatment decreased the harmful effect of infection but some significant differences were shown between infected and treated groups and non infected and non treated group in assessment criteria. Furthermore, the histopathological findings were also discussed. In conclusion, the current study showed that the application of both tested drugs gave significant and satisfactory improvement in the assessment criteria as well as they are effective in control of coccidiosis caused by Eimeria tenella.
format Article
author Hagag, Dina
El-Shazly, Kamal
Abd El-Aziz, Magdy
Abd El-Latif, Amira
El Sharkaway, Hanem
Abdo, Walied
Barakat, Mohamed
spellingShingle Hagag, Dina
El-Shazly, Kamal
Abd El-Aziz, Magdy
Abd El-Latif, Amira
El Sharkaway, Hanem
Abdo, Walied
Barakat, Mohamed
Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens
author_facet Hagag, Dina
El-Shazly, Kamal
Abd El-Aziz, Magdy
Abd El-Latif, Amira
El Sharkaway, Hanem
Abdo, Walied
Barakat, Mohamed
author_sort Hagag, Dina
title Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens
title_short Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens
title_full Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens
title_fullStr Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens
title_full_unstemmed Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens
title_sort assessment of anticoccidial efficacy of novel triazine compound and sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2020
url http://journalarticle.ukm.my/15994/1/3.pdf
http://journalarticle.ukm.my/15994/
https://www.ukm.my/jsm/malay_journals/jilid49bil11_2020/KandunganJilid49Bil11_2020.html
_version_ 1687394679941758976
score 13.211869

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