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Improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery

Gelatin has been widely used as a nature-derived biopolymer material due to its high biocompatibility and abundance. However, multiple fabrication steps for the moulding process may limit its application to microneedle technology as biomedical application. This research focused on physical, chemic...

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Main Authors: Nur Afiqah Mustafa Kamal,, Ishak Ahmad,, Suria Ramli,, Tuan Mazlelaa Tuan Mahmood,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2020
Online Access:http://journalarticle.ukm.my/15922/1/24.pdf
http://journalarticle.ukm.my/15922/
http://www.ukm.my/jsm/malay_journals/jilid49bil9_2020/KandunganJilid49Bil9_2020.html
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spelling my-ukm.journal.159222020-12-07T17:10:28Z http://journalarticle.ukm.my/15922/ Improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery Nur Afiqah Mustafa Kamal, Ishak Ahmad, Suria Ramli, Tuan Mazlelaa Tuan Mahmood, Gelatin has been widely used as a nature-derived biopolymer material due to its high biocompatibility and abundance. However, multiple fabrication steps for the moulding process may limit its application to microneedle technology as biomedical application. This research focused on physical, chemical, and mechanical characteristics of gelatin-based dissolving microneedle (DMN) by adding in various concentrations of carboxymethylcellulose. Carboxymethylcellulose (CMC) derived from kenaf bast fibre were extracted by alkaline treatment and esterification process, followed by fabrication of DMN with gelatin using centrifuge-casting method. The formulation of G/CMC6 demonstrated the highest mechanical strength of 11.2 N by texture analyzer; hence, G/CMC6 was chosen for further investigate of its intra- and intermolecular bond, amorphous study, and its geometry by Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). FTIR showed various chemical interactions involved including hydrogen bonding, dipole-dipole and charge effect. The XRD result shows amorphous peak of gelatin decreased at 2θ = 20 - 21° with the addition of CMC. The height of microneedle arrays also decreased from its micromould by 36.7% due to agglomeration of CMC. Considering the biodegradability and the improvement of gelatinbased DMN mechanical properties by carboxymethylcellulose, the combination of gelatin and CMC is one of great potential for delivering drugs using microneedle. Penerbit Universiti Kebangsaan Malaysia 2020-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15922/1/24.pdf Nur Afiqah Mustafa Kamal, and Ishak Ahmad, and Suria Ramli, and Tuan Mazlelaa Tuan Mahmood, (2020) Improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery. Sains Malaysiana, 49 (9). pp. 2269-2279. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil9_2020/KandunganJilid49Bil9_2020.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Gelatin has been widely used as a nature-derived biopolymer material due to its high biocompatibility and abundance. However, multiple fabrication steps for the moulding process may limit its application to microneedle technology as biomedical application. This research focused on physical, chemical, and mechanical characteristics of gelatin-based dissolving microneedle (DMN) by adding in various concentrations of carboxymethylcellulose. Carboxymethylcellulose (CMC) derived from kenaf bast fibre were extracted by alkaline treatment and esterification process, followed by fabrication of DMN with gelatin using centrifuge-casting method. The formulation of G/CMC6 demonstrated the highest mechanical strength of 11.2 N by texture analyzer; hence, G/CMC6 was chosen for further investigate of its intra- and intermolecular bond, amorphous study, and its geometry by Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). FTIR showed various chemical interactions involved including hydrogen bonding, dipole-dipole and charge effect. The XRD result shows amorphous peak of gelatin decreased at 2θ = 20 - 21° with the addition of CMC. The height of microneedle arrays also decreased from its micromould by 36.7% due to agglomeration of CMC. Considering the biodegradability and the improvement of gelatinbased DMN mechanical properties by carboxymethylcellulose, the combination of gelatin and CMC is one of great potential for delivering drugs using microneedle.
format Article
author Nur Afiqah Mustafa Kamal,
Ishak Ahmad,
Suria Ramli,
Tuan Mazlelaa Tuan Mahmood,
spellingShingle Nur Afiqah Mustafa Kamal,
Ishak Ahmad,
Suria Ramli,
Tuan Mazlelaa Tuan Mahmood,
Improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery
author_facet Nur Afiqah Mustafa Kamal,
Ishak Ahmad,
Suria Ramli,
Tuan Mazlelaa Tuan Mahmood,
author_sort Nur Afiqah Mustafa Kamal,
title Improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery
title_short Improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery
title_full Improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery
title_fullStr Improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery
title_full_unstemmed Improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery
title_sort improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2020
url http://journalarticle.ukm.my/15922/1/24.pdf
http://journalarticle.ukm.my/15922/
http://www.ukm.my/jsm/malay_journals/jilid49bil9_2020/KandunganJilid49Bil9_2020.html
_version_ 1685579816028340224
score 13.211869

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