Improving rate of gelatin/carboxymethylcellulose dissolving microneedle for transdermal drug delivery
Gelatin has been widely used as a nature-derived biopolymer material due to its high biocompatibility and abundance. However, multiple fabrication steps for the moulding process may limit its application to microneedle technology as biomedical application. This research focused on physical, chemic...
محفوظ في:
| المؤلفون الرئيسيون: | , , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Penerbit Universiti Kebangsaan Malaysia
2020
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| الوصول للمادة أونلاين: | http://journalarticle.ukm.my/15922/1/24.pdf http://journalarticle.ukm.my/15922/ http://www.ukm.my/jsm/malay_journals/jilid49bil9_2020/KandunganJilid49Bil9_2020.html |
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| الملخص: | Gelatin has been widely used as a nature-derived biopolymer material due to its high biocompatibility and
abundance. However, multiple fabrication steps for the moulding process may limit its application to microneedle
technology as biomedical application. This research focused on physical, chemical, and mechanical characteristics
of gelatin-based dissolving microneedle (DMN) by adding in various concentrations of carboxymethylcellulose.
Carboxymethylcellulose (CMC) derived from kenaf bast fibre were extracted by alkaline treatment and esterification
process, followed by fabrication of DMN with gelatin using centrifuge-casting method. The formulation of G/CMC6
demonstrated the highest mechanical strength of 11.2 N by texture analyzer; hence, G/CMC6 was chosen for further
investigate of its intra- and intermolecular bond, amorphous study, and its geometry by Fourier Transform Infrared
(FTIR), X-ray Diffraction (XRD) and Scanning Electron Microscopy (SEM). FTIR showed various chemical interactions
involved including hydrogen bonding, dipole-dipole and charge effect. The XRD result shows amorphous peak of gelatin
decreased at 2θ = 20 - 21° with the addition of CMC. The height of microneedle arrays also decreased from its
micromould by 36.7% due to agglomeration of CMC. Considering the biodegradability and the improvement of gelatinbased DMN mechanical properties by carboxymethylcellulose, the combination of gelatin and CMC is one of great
potential for delivering drugs using microneedle. |
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